Dietary intake of branched-chain amino acids and risk of colorectal cancer

Ryoko Katagiri; Mingyang Song; Xuehong Zhang; Dong Hoon Lee; Fred K. Tabung; Charles S. Fuchs; Jeffrey A. Meyerhardt; Reiko Nishihara; Andrew T. Chan; Amit D. Joshi; Motoki Iwasaki; Shuji Ogino; Walter C. Willett; Edward Giovannucci; Kana Wu

doi:10.1158/1940-6207.CAPR-19-0297

Dietary intake of branched-chain amino acids and risk of colorectal cancer

Ryoko Katagiri, Mingyang Song, Xuehong Zhang, Dong Hoon Lee, Fred K. Tabung, Charles S. Fuchs, Jeffrey A. Meyerhardt, Reiko Nishihara, Andrew T. Chan, Amit D. Joshi, Motoki Iwasaki, Shuji Ogino, Walter C. Willett, Edward Giovannucci, Kana Wu

Department of Sports Industry Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Branched-chain amino acids (BCAA) are essential amino acids, and emerging evidence suggests that BCAAs may mediate pathways related to cancer progression, possibly due to their involvement in insulin metabolism. We investigated the association between dietary intake of BCAAs with colorectal cancer risk in three prospective cohorts: the Nurses' Health Study I [(NHS), number of participants (n) at baseline ¼ 77,017], NHS II (n ¼ 92,984), and the Health Professionals Follow-up Study [(HPFS) n ¼ 47,255]. Validated food frequency questionnaires were administered every 4 years and follow-up questionnaires on lifestyle biennially. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression models. Pooled HRs were obtained using random effect models. After up to 28 years of follow-up, 1,660 cases were observed in NHS, 306 in NHS II, and 1,343 in HPFS. In multivariable adjusted models, we observed a weak inverse association between BCAA intake and colorectal cancer [highest vs. lowest quintile, pooled HR including all three cohorts (95% CI): 0.89 (0.80-1.00), P_trend ¼ 0.06, HR per standard deviation (SD) increment 0.95 (0.92-0.99)]. However, after including dairy calcium to the models, BCAA intake was no longer associated with risk of colorectal cancer [HR 0.96 (0.85-1.08), P_trend ¼ 0.50, HR per SD increment 0.97 (0.93-1.01)]. We did not find evidence that higher dietary BCAA intake is associated with higher risk of colorectal cancer. As this is the first prospective study to examine the association between BCAA intake and colorectal cancer, our findings warrant investigation in other cohorts.

Original language	English
Pages (from-to)	65-72
Number of pages	8
Journal	Cancer Prevention Research
Volume	13
Issue number	1
DOIs	https://doi.org/10.1158/1940-6207.CAPR-19-0297
Publication status	Published - 2020

Bibliographical note

Funding Information:
We would like to thank the participants and staff of the Nurses' Health Study, the Nurses' Health Study II, and the Health Professionals Follow-up Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by NIH grants (P01 CA87969 to M.J. Stampfer; UM1 CA186107 to M.J. Stampfer; UM1 CA176726 to W.C. Willett; P01 CA55075 to W.C. Willett; UM1 CA167552 to W.C. Willett; U01 CA167552 to W.C. Willett and L.A. Mucci; P50 CA127003 to C.S. Fuchs; R01 CA137178 to A.T. Chan; K24 DK098311 to A.T. Chan; R35 CA197735 to S. Ogino; R01 CA151993 to S. Ogino; R21 CA222940 to K. Wu and R. Nishihara; R21 CA230873 to K. Wu and S. Ogino; K07 CA188126 to X. Zhang; and R00 CA207736 to F.K. Tabung), Nodal Award from the Dana-Farber Harvard Cancer Center (to S. Ogino), and grants from the Project P Fund, The Friends of the Dana-Farber Cancer Institute, Bennett Family Fund, and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. This research was supported by a Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (grant number SU2C-AACR-DT22-17). Stand Up To Cancer is a division of the Entertainment Industry Foundation. Research grants are administered by the American Association for Cancer Research, the scientific partner of SU2C (to C.S. Fuchs). This work was also, in part, supported by an Investigator Initiated Grants from the American Institute for Cancer Research (AICR) to K. Wu.

Funding Information:
This work was supported by NIH grants (P01 CA87969 to M.J. Stampfer; UM1 CA186107 to M.J. Stampfer; UM1 CA176726 to W.C. Willett; P01 CA55075 to W.C. Willett; UM1 CA167552 to W.C. Willett; U01 CA167552 to W.C. Willett and L.A. Mucci; P50 CA127003 to C.S. Fuchs; R01 CA137178 to A.T. Chan; K24 DK098311 to A.T. Chan; R35 CA197735 to S. Ogino; R01 CA151993 to S. Ogino; R21 CA222940 to K. Wu and R. Nishihara; R21 CA230873 to K. Wu and S. Ogino; K07 CA188126 to X. Zhang; and R00 CA207736 to F.K. Tabung), Nodal Award from the Dana-Farber Harvard Cancer Center (to S. Ogino), and grants from the Project P Fund, The Friends of the Dana-Farber Cancer Institute, Bennett Family Fund, and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. This research was supported by a Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (grant number SU2C-AACR-DT22-17). Stand Up To Cancer is a division of the Entertainment Industry Foundation. Research grants are administered by the American Association for Cancer Research, the scientific partner of SU2C (to C.S. Fuchs). This work was also, in part, supported by an Investigator Initiated Grants from the American Institute for Cancer Research (AICR) to K. Wu.

Publisher Copyright:
© 2019 American Association for Cancer Research.

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1940-6207.CAPR-19-0297

Cite this

Katagiri, R., Song, M., Zhang, X., Lee, D. H., Tabung, F. K., Fuchs, C. S., Meyerhardt, J. A., Nishihara, R., Chan, A. T., Joshi, A. D., Iwasaki, M., Ogino, S., Willett, W. C., Giovannucci, E., & Wu, K. (2020). Dietary intake of branched-chain amino acids and risk of colorectal cancer. Cancer Prevention Research, 13(1), 65-72. https://doi.org/10.1158/1940-6207.CAPR-19-0297

@article{887d501513564deebb0a140ba047b19c,

title = "Dietary intake of branched-chain amino acids and risk of colorectal cancer",

abstract = "Branched-chain amino acids (BCAA) are essential amino acids, and emerging evidence suggests that BCAAs may mediate pathways related to cancer progression, possibly due to their involvement in insulin metabolism. We investigated the association between dietary intake of BCAAs with colorectal cancer risk in three prospective cohorts: the Nurses' Health Study I [(NHS), number of participants (n) at baseline ¼ 77,017], NHS II (n ¼ 92,984), and the Health Professionals Follow-up Study [(HPFS) n ¼ 47,255]. Validated food frequency questionnaires were administered every 4 years and follow-up questionnaires on lifestyle biennially. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression models. Pooled HRs were obtained using random effect models. After up to 28 years of follow-up, 1,660 cases were observed in NHS, 306 in NHS II, and 1,343 in HPFS. In multivariable adjusted models, we observed a weak inverse association between BCAA intake and colorectal cancer [highest vs. lowest quintile, pooled HR including all three cohorts (95% CI): 0.89 (0.80-1.00), Ptrend ¼ 0.06, HR per standard deviation (SD) increment 0.95 (0.92-0.99)]. However, after including dairy calcium to the models, BCAA intake was no longer associated with risk of colorectal cancer [HR 0.96 (0.85-1.08), Ptrend ¼ 0.50, HR per SD increment 0.97 (0.93-1.01)]. We did not find evidence that higher dietary BCAA intake is associated with higher risk of colorectal cancer. As this is the first prospective study to examine the association between BCAA intake and colorectal cancer, our findings warrant investigation in other cohorts.",

author = "Ryoko Katagiri and Mingyang Song and Xuehong Zhang and Lee, {Dong Hoon} and Tabung, {Fred K.} and Fuchs, {Charles S.} and Meyerhardt, {Jeffrey A.} and Reiko Nishihara and Chan, {Andrew T.} and Joshi, {Amit D.} and Motoki Iwasaki and Shuji Ogino and Willett, {Walter C.} and Edward Giovannucci and Kana Wu",

note = "Funding Information: We would like to thank the participants and staff of the Nurses' Health Study, the Nurses' Health Study II, and the Health Professionals Follow-up Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by NIH grants (P01 CA87969 to M.J. Stampfer; UM1 CA186107 to M.J. Stampfer; UM1 CA176726 to W.C. Willett; P01 CA55075 to W.C. Willett; UM1 CA167552 to W.C. Willett; U01 CA167552 to W.C. Willett and L.A. Mucci; P50 CA127003 to C.S. Fuchs; R01 CA137178 to A.T. Chan; K24 DK098311 to A.T. Chan; R35 CA197735 to S. Ogino; R01 CA151993 to S. Ogino; R21 CA222940 to K. Wu and R. Nishihara; R21 CA230873 to K. Wu and S. Ogino; K07 CA188126 to X. Zhang; and R00 CA207736 to F.K. Tabung), Nodal Award from the Dana-Farber Harvard Cancer Center (to S. Ogino), and grants from the Project P Fund, The Friends of the Dana-Farber Cancer Institute, Bennett Family Fund, and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. This research was supported by a Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (grant number SU2C-AACR-DT22-17). Stand Up To Cancer is a division of the Entertainment Industry Foundation. Research grants are administered by the American Association for Cancer Research, the scientific partner of SU2C (to C.S. Fuchs). This work was also, in part, supported by an Investigator Initiated Grants from the American Institute for Cancer Research (AICR) to K. Wu. Funding Information: This work was supported by NIH grants (P01 CA87969 to M.J. Stampfer; UM1 CA186107 to M.J. Stampfer; UM1 CA176726 to W.C. Willett; P01 CA55075 to W.C. Willett; UM1 CA167552 to W.C. Willett; U01 CA167552 to W.C. Willett and L.A. Mucci; P50 CA127003 to C.S. Fuchs; R01 CA137178 to A.T. Chan; K24 DK098311 to A.T. Chan; R35 CA197735 to S. Ogino; R01 CA151993 to S. Ogino; R21 CA222940 to K. Wu and R. Nishihara; R21 CA230873 to K. Wu and S. Ogino; K07 CA188126 to X. Zhang; and R00 CA207736 to F.K. Tabung), Nodal Award from the Dana-Farber Harvard Cancer Center (to S. Ogino), and grants from the Project P Fund, The Friends of the Dana-Farber Cancer Institute, Bennett Family Fund, and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. This research was supported by a Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (grant number SU2C-AACR-DT22-17). Stand Up To Cancer is a division of the Entertainment Industry Foundation. Research grants are administered by the American Association for Cancer Research, the scientific partner of SU2C (to C.S. Fuchs). This work was also, in part, supported by an Investigator Initiated Grants from the American Institute for Cancer Research (AICR) to K. Wu. Publisher Copyright: {\textcopyright} 2019 American Association for Cancer Research.",

year = "2020",

doi = "10.1158/1940-6207.CAPR-19-0297",

language = "English",

volume = "13",

pages = "65--72",

journal = "Cancer Prevention Research",

issn = "1940-6207",

publisher = "American Association for Cancer Research Inc.",

number = "1",

}

TY - JOUR

T1 - Dietary intake of branched-chain amino acids and risk of colorectal cancer

AU - Katagiri, Ryoko

AU - Song, Mingyang

AU - Zhang, Xuehong

AU - Lee, Dong Hoon

AU - Tabung, Fred K.

AU - Fuchs, Charles S.

AU - Meyerhardt, Jeffrey A.

AU - Nishihara, Reiko

AU - Chan, Andrew T.

AU - Joshi, Amit D.

AU - Iwasaki, Motoki

AU - Ogino, Shuji

AU - Willett, Walter C.

AU - Giovannucci, Edward

AU - Wu, Kana

N1 - Funding Information: We would like to thank the participants and staff of the Nurses' Health Study, the Nurses' Health Study II, and the Health Professionals Follow-up Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by NIH grants (P01 CA87969 to M.J. Stampfer; UM1 CA186107 to M.J. Stampfer; UM1 CA176726 to W.C. Willett; P01 CA55075 to W.C. Willett; UM1 CA167552 to W.C. Willett; U01 CA167552 to W.C. Willett and L.A. Mucci; P50 CA127003 to C.S. Fuchs; R01 CA137178 to A.T. Chan; K24 DK098311 to A.T. Chan; R35 CA197735 to S. Ogino; R01 CA151993 to S. Ogino; R21 CA222940 to K. Wu and R. Nishihara; R21 CA230873 to K. Wu and S. Ogino; K07 CA188126 to X. Zhang; and R00 CA207736 to F.K. Tabung), Nodal Award from the Dana-Farber Harvard Cancer Center (to S. Ogino), and grants from the Project P Fund, The Friends of the Dana-Farber Cancer Institute, Bennett Family Fund, and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. This research was supported by a Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (grant number SU2C-AACR-DT22-17). Stand Up To Cancer is a division of the Entertainment Industry Foundation. Research grants are administered by the American Association for Cancer Research, the scientific partner of SU2C (to C.S. Fuchs). This work was also, in part, supported by an Investigator Initiated Grants from the American Institute for Cancer Research (AICR) to K. Wu. Funding Information: This work was supported by NIH grants (P01 CA87969 to M.J. Stampfer; UM1 CA186107 to M.J. Stampfer; UM1 CA176726 to W.C. Willett; P01 CA55075 to W.C. Willett; UM1 CA167552 to W.C. Willett; U01 CA167552 to W.C. Willett and L.A. Mucci; P50 CA127003 to C.S. Fuchs; R01 CA137178 to A.T. Chan; K24 DK098311 to A.T. Chan; R35 CA197735 to S. Ogino; R01 CA151993 to S. Ogino; R21 CA222940 to K. Wu and R. Nishihara; R21 CA230873 to K. Wu and S. Ogino; K07 CA188126 to X. Zhang; and R00 CA207736 to F.K. Tabung), Nodal Award from the Dana-Farber Harvard Cancer Center (to S. Ogino), and grants from the Project P Fund, The Friends of the Dana-Farber Cancer Institute, Bennett Family Fund, and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance. This research was supported by a Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (grant number SU2C-AACR-DT22-17). Stand Up To Cancer is a division of the Entertainment Industry Foundation. Research grants are administered by the American Association for Cancer Research, the scientific partner of SU2C (to C.S. Fuchs). This work was also, in part, supported by an Investigator Initiated Grants from the American Institute for Cancer Research (AICR) to K. Wu. Publisher Copyright: © 2019 American Association for Cancer Research.

PY - 2020

Y1 - 2020

N2 - Branched-chain amino acids (BCAA) are essential amino acids, and emerging evidence suggests that BCAAs may mediate pathways related to cancer progression, possibly due to their involvement in insulin metabolism. We investigated the association between dietary intake of BCAAs with colorectal cancer risk in three prospective cohorts: the Nurses' Health Study I [(NHS), number of participants (n) at baseline ¼ 77,017], NHS II (n ¼ 92,984), and the Health Professionals Follow-up Study [(HPFS) n ¼ 47,255]. Validated food frequency questionnaires were administered every 4 years and follow-up questionnaires on lifestyle biennially. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression models. Pooled HRs were obtained using random effect models. After up to 28 years of follow-up, 1,660 cases were observed in NHS, 306 in NHS II, and 1,343 in HPFS. In multivariable adjusted models, we observed a weak inverse association between BCAA intake and colorectal cancer [highest vs. lowest quintile, pooled HR including all three cohorts (95% CI): 0.89 (0.80-1.00), Ptrend ¼ 0.06, HR per standard deviation (SD) increment 0.95 (0.92-0.99)]. However, after including dairy calcium to the models, BCAA intake was no longer associated with risk of colorectal cancer [HR 0.96 (0.85-1.08), Ptrend ¼ 0.50, HR per SD increment 0.97 (0.93-1.01)]. We did not find evidence that higher dietary BCAA intake is associated with higher risk of colorectal cancer. As this is the first prospective study to examine the association between BCAA intake and colorectal cancer, our findings warrant investigation in other cohorts.

AB - Branched-chain amino acids (BCAA) are essential amino acids, and emerging evidence suggests that BCAAs may mediate pathways related to cancer progression, possibly due to their involvement in insulin metabolism. We investigated the association between dietary intake of BCAAs with colorectal cancer risk in three prospective cohorts: the Nurses' Health Study I [(NHS), number of participants (n) at baseline ¼ 77,017], NHS II (n ¼ 92,984), and the Health Professionals Follow-up Study [(HPFS) n ¼ 47,255]. Validated food frequency questionnaires were administered every 4 years and follow-up questionnaires on lifestyle biennially. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression models. Pooled HRs were obtained using random effect models. After up to 28 years of follow-up, 1,660 cases were observed in NHS, 306 in NHS II, and 1,343 in HPFS. In multivariable adjusted models, we observed a weak inverse association between BCAA intake and colorectal cancer [highest vs. lowest quintile, pooled HR including all three cohorts (95% CI): 0.89 (0.80-1.00), Ptrend ¼ 0.06, HR per standard deviation (SD) increment 0.95 (0.92-0.99)]. However, after including dairy calcium to the models, BCAA intake was no longer associated with risk of colorectal cancer [HR 0.96 (0.85-1.08), Ptrend ¼ 0.50, HR per SD increment 0.97 (0.93-1.01)]. We did not find evidence that higher dietary BCAA intake is associated with higher risk of colorectal cancer. As this is the first prospective study to examine the association between BCAA intake and colorectal cancer, our findings warrant investigation in other cohorts.

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Dietary intake of branched-chain amino acids and risk of colorectal cancer

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