Objective: We aimed to evaluate whether 4-week of dietary treatment with rice containing resistant starch reduces blood glucose and oxidative stress as well as improves endothelial function. Methods: Patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly diagnosed type 2 diabetes (n = 90) were randomly assigned to either a group ingesting rice containing 6.51 g resistant starch daily or a control rice group for 4-weeks. We assessed fasting and postprandial levels of glucose and insulin, oxidative stress markers and endothelial function using reactive hyperemia peripheral arterial tonometry (RH-PAT). Results: The diet containing rice with resistant starch reduced fasting insulin and insulin resistance, postprandial glucose (P = 0.010) and insulin levels at 30 min, and glucose and insulin areas under the response curve after the standard meal. Rice with resistant starch also decreased urinary 8-epi-PGF2α and plasma malondialdehyde (MDA) and increased the RH-PAT index (P < 0.001) and total nitric oxide (NO). Postprandial changes in glucose at 60 and 120 min and areas under the glucose response curve, MDA, RH-PAT, and total NO of the test group differed significantly from those in the control even after adjusting for baseline values. Overall, changes in the RH-PAT index correlated positively with changes in total NO (r = 0.336, P = 0.003) and superoxide dismutase activity (r = 0.381, P = 0.001) and negatively with changes in MDA (r = -0.358, P = 0.002) and 8-epi-PGF2α. Conclusions: In patients with IFG, IGT or newly diagnosed type 2 diabetes, 4-weeks of dietary treatment with rice containing resistant starch was associated with improved endothelial function with reduction of postprandial glucose and oxidative stress compared with control.
|Number of pages||8|
|Publication status||Published - 2012 Oct|
Bibliographical noteFunding Information:
This work was supported by the Korean National Health Insurance Corporation and the Mid-career Researcher Program through National Research Foundation of Korea (2012-0005604), Republic of Korea.
This work was supported by the Korean National Health Insurance Corporation and the Mid-career Researcher Program through National Research Foundation of Korea ( 2012-0005604 ), Republic of Korea. We thank the research volunteers who participated in the studies described in this report. All the authors were involved in the development of the study protocol and the study design. Sample collection and experiments were performed by JHK, JKP, HIK, OYK, DYS, and H-JK. Data were analyzed by JHK, and JKP. JHL and JHL provided the research funding and JHL wrote the manuscript. All the authors read, commented on, and contributed to the submitted manuscript. None of the authors have any conflicts of interest in relation to the materials presented in this paper.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine