Difference in occurrence of heterotopic ossification according to prosthesis type in the cervical artificial disc replacement

Seong Yi, Keung Nyun Kim, Moon Sul Yang, Joong Won Yang, Hoon Kim, Yoon Ha, Do Heum Yoon, Hyun Chul Shin

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Study Design: Retrospective study of the difference of heterotopic ossification (HO) occurrence according to 3 different types of prosthesis. Objective: This study was designed to investigate the difference of HO occurrence according to different type of prosthesis. Summary of Background Data: HO is defined as formation of the bone outside the skeletal system. Reported HO occurrence rate in cervical artificial disc replacement (ADR) was unexpectedly high and varied. But the influencing factors of HO in cervical ADR have not been elucidated well. The prosthesis-related factors for making difference of HO occurrence were investigated in this study. Methods: A total of 170 patients undergoing cervical arthroplasty with the Bryan cervical disc prosthesis (Medtroic Sofamor Danek, Memphis, TN), Mobi-C disc prosthesis (LDR Medical, Troyes, France), and ProDisc-C (Synthes, Inc., West Chester, PA) were included. Cervical lateral radiographs obtained before and after surgery were used to identify HO. Occurrence rate, occurrence-free period, location, and grade of HOs were investigated according to the different prosthesis. Results: Each prosthesis group included patients as follows: Bryan disc, 81 patients; Mobi-C, 61 patients; and ProDisc-C, 28 patients. Overall HO rate was 40.6% (69 of 170 patients). Each HO occurrence rate by prosthesis was as follows: the Bryan disc group, 21.0%; Mobi-C group, 52.5%; and the ProDisc-C group, 71.4%. In the survival analysis, all patients showed 27.1 ± 3.7 months as the median survival. The Bryan disc group showed statistically longer survival (48.4 ± 7.4 months) than the other groups. Conclusion: Occurrence of HO is an inevitable postoperative complication after cervical ADR. The occurrence rate of HO was higher than our expectation. Moreover, definite differences in occurrence rate according to the prosthe is type were identified by this study.

Original languageEnglish
Pages (from-to)1556-1561
Number of pages6
JournalSpine
Volume35
Issue number16
DOIs
Publication statusPublished - 2010 Jul 15

Fingerprint

Total Disc Replacement
Heterotopic Ossification
Prostheses and Implants
Survival
Survival Analysis
Osteogenesis
Arthroplasty
France

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Yi, Seong ; Kim, Keung Nyun ; Yang, Moon Sul ; Yang, Joong Won ; Kim, Hoon ; Ha, Yoon ; Yoon, Do Heum ; Shin, Hyun Chul. / Difference in occurrence of heterotopic ossification according to prosthesis type in the cervical artificial disc replacement. In: Spine. 2010 ; Vol. 35, No. 16. pp. 1556-1561.
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title = "Difference in occurrence of heterotopic ossification according to prosthesis type in the cervical artificial disc replacement",
abstract = "Study Design: Retrospective study of the difference of heterotopic ossification (HO) occurrence according to 3 different types of prosthesis. Objective: This study was designed to investigate the difference of HO occurrence according to different type of prosthesis. Summary of Background Data: HO is defined as formation of the bone outside the skeletal system. Reported HO occurrence rate in cervical artificial disc replacement (ADR) was unexpectedly high and varied. But the influencing factors of HO in cervical ADR have not been elucidated well. The prosthesis-related factors for making difference of HO occurrence were investigated in this study. Methods: A total of 170 patients undergoing cervical arthroplasty with the Bryan cervical disc prosthesis (Medtroic Sofamor Danek, Memphis, TN), Mobi-C disc prosthesis (LDR Medical, Troyes, France), and ProDisc-C (Synthes, Inc., West Chester, PA) were included. Cervical lateral radiographs obtained before and after surgery were used to identify HO. Occurrence rate, occurrence-free period, location, and grade of HOs were investigated according to the different prosthesis. Results: Each prosthesis group included patients as follows: Bryan disc, 81 patients; Mobi-C, 61 patients; and ProDisc-C, 28 patients. Overall HO rate was 40.6{\%} (69 of 170 patients). Each HO occurrence rate by prosthesis was as follows: the Bryan disc group, 21.0{\%}; Mobi-C group, 52.5{\%}; and the ProDisc-C group, 71.4{\%}. In the survival analysis, all patients showed 27.1 ± 3.7 months as the median survival. The Bryan disc group showed statistically longer survival (48.4 ± 7.4 months) than the other groups. Conclusion: Occurrence of HO is an inevitable postoperative complication after cervical ADR. The occurrence rate of HO was higher than our expectation. Moreover, definite differences in occurrence rate according to the prosthe is type were identified by this study.",
author = "Seong Yi and Kim, {Keung Nyun} and Yang, {Moon Sul} and Yang, {Joong Won} and Hoon Kim and Yoon Ha and Yoon, {Do Heum} and Shin, {Hyun Chul}",
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Difference in occurrence of heterotopic ossification according to prosthesis type in the cervical artificial disc replacement. / Yi, Seong; Kim, Keung Nyun; Yang, Moon Sul; Yang, Joong Won; Kim, Hoon; Ha, Yoon; Yoon, Do Heum; Shin, Hyun Chul.

In: Spine, Vol. 35, No. 16, 15.07.2010, p. 1556-1561.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Difference in occurrence of heterotopic ossification according to prosthesis type in the cervical artificial disc replacement

AU - Yi, Seong

AU - Kim, Keung Nyun

AU - Yang, Moon Sul

AU - Yang, Joong Won

AU - Kim, Hoon

AU - Ha, Yoon

AU - Yoon, Do Heum

AU - Shin, Hyun Chul

PY - 2010/7/15

Y1 - 2010/7/15

N2 - Study Design: Retrospective study of the difference of heterotopic ossification (HO) occurrence according to 3 different types of prosthesis. Objective: This study was designed to investigate the difference of HO occurrence according to different type of prosthesis. Summary of Background Data: HO is defined as formation of the bone outside the skeletal system. Reported HO occurrence rate in cervical artificial disc replacement (ADR) was unexpectedly high and varied. But the influencing factors of HO in cervical ADR have not been elucidated well. The prosthesis-related factors for making difference of HO occurrence were investigated in this study. Methods: A total of 170 patients undergoing cervical arthroplasty with the Bryan cervical disc prosthesis (Medtroic Sofamor Danek, Memphis, TN), Mobi-C disc prosthesis (LDR Medical, Troyes, France), and ProDisc-C (Synthes, Inc., West Chester, PA) were included. Cervical lateral radiographs obtained before and after surgery were used to identify HO. Occurrence rate, occurrence-free period, location, and grade of HOs were investigated according to the different prosthesis. Results: Each prosthesis group included patients as follows: Bryan disc, 81 patients; Mobi-C, 61 patients; and ProDisc-C, 28 patients. Overall HO rate was 40.6% (69 of 170 patients). Each HO occurrence rate by prosthesis was as follows: the Bryan disc group, 21.0%; Mobi-C group, 52.5%; and the ProDisc-C group, 71.4%. In the survival analysis, all patients showed 27.1 ± 3.7 months as the median survival. The Bryan disc group showed statistically longer survival (48.4 ± 7.4 months) than the other groups. Conclusion: Occurrence of HO is an inevitable postoperative complication after cervical ADR. The occurrence rate of HO was higher than our expectation. Moreover, definite differences in occurrence rate according to the prosthe is type were identified by this study.

AB - Study Design: Retrospective study of the difference of heterotopic ossification (HO) occurrence according to 3 different types of prosthesis. Objective: This study was designed to investigate the difference of HO occurrence according to different type of prosthesis. Summary of Background Data: HO is defined as formation of the bone outside the skeletal system. Reported HO occurrence rate in cervical artificial disc replacement (ADR) was unexpectedly high and varied. But the influencing factors of HO in cervical ADR have not been elucidated well. The prosthesis-related factors for making difference of HO occurrence were investigated in this study. Methods: A total of 170 patients undergoing cervical arthroplasty with the Bryan cervical disc prosthesis (Medtroic Sofamor Danek, Memphis, TN), Mobi-C disc prosthesis (LDR Medical, Troyes, France), and ProDisc-C (Synthes, Inc., West Chester, PA) were included. Cervical lateral radiographs obtained before and after surgery were used to identify HO. Occurrence rate, occurrence-free period, location, and grade of HOs were investigated according to the different prosthesis. Results: Each prosthesis group included patients as follows: Bryan disc, 81 patients; Mobi-C, 61 patients; and ProDisc-C, 28 patients. Overall HO rate was 40.6% (69 of 170 patients). Each HO occurrence rate by prosthesis was as follows: the Bryan disc group, 21.0%; Mobi-C group, 52.5%; and the ProDisc-C group, 71.4%. In the survival analysis, all patients showed 27.1 ± 3.7 months as the median survival. The Bryan disc group showed statistically longer survival (48.4 ± 7.4 months) than the other groups. Conclusion: Occurrence of HO is an inevitable postoperative complication after cervical ADR. The occurrence rate of HO was higher than our expectation. Moreover, definite differences in occurrence rate according to the prosthe is type were identified by this study.

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