Differences in clinical features and oncologic outcomes between metastatic right and left colon cancer

Kwangmin Kim, Young Wan Kim, Hongjin Shim, Bo Ra Kim, Hye Youn Kwon

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Approximately 20% to 25% of patients with colorectal cancer (CRC) have distant organ metastasis at the time of initial diagnosis. The primary tumor location has been suggested as a prognostic factor for patients with metastatic CRC. In recent years, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has been brought into focus due to their different outcomes, prognoses, and clinical responses to chemotherapy. In this article we aimed to review the underlying differences between metastatic RCC and LCC in terms of epidemiology, clinical features, and oncologic outcomes. The outcomes of patients with left-sided tumors were better than those of patients with right-sided tumors in terms of overall survival (OS) and objective response rate (ORR) after treatment with chemotherapy + panitumumab in the PRIME and 20050181 trials. The outcomes of patients with LCC were better than those of patients with RCC in terms of OS, progression-free survival (PFS) and ORR after treatment with FOLFIRI + cetuximab in the CRYSTAL and CALGB 80405 trials. In the FIRE-3 trial, the OS and PFS, but not the ORR, of patients with LCC were superior to those of patients with RCC. LCC and RCC exhibit distinctive clinical features and epidemiology. However, we must further investigate the impact of these distinctive features and how they influence the differential oncologic outcomes.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalJournal of B.U.ON.
Volume23
Publication statusPublished - 2018 Jan 1

Fingerprint

Colonic Neoplasms
Patient Rights
Disease-Free Survival
Survival
Colorectal Neoplasms
Epidemiology
Drug Therapy
Neoplasms
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Kim, Kwangmin ; Kim, Young Wan ; Shim, Hongjin ; Kim, Bo Ra ; Kwon, Hye Youn. / Differences in clinical features and oncologic outcomes between metastatic right and left colon cancer. In: Journal of B.U.ON. 2018 ; Vol. 23. pp. 11-18.
@article{3127268dcc1846b0b29e3a3562536b2d,
title = "Differences in clinical features and oncologic outcomes between metastatic right and left colon cancer",
abstract = "Approximately 20{\%} to 25{\%} of patients with colorectal cancer (CRC) have distant organ metastasis at the time of initial diagnosis. The primary tumor location has been suggested as a prognostic factor for patients with metastatic CRC. In recent years, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has been brought into focus due to their different outcomes, prognoses, and clinical responses to chemotherapy. In this article we aimed to review the underlying differences between metastatic RCC and LCC in terms of epidemiology, clinical features, and oncologic outcomes. The outcomes of patients with left-sided tumors were better than those of patients with right-sided tumors in terms of overall survival (OS) and objective response rate (ORR) after treatment with chemotherapy + panitumumab in the PRIME and 20050181 trials. The outcomes of patients with LCC were better than those of patients with RCC in terms of OS, progression-free survival (PFS) and ORR after treatment with FOLFIRI + cetuximab in the CRYSTAL and CALGB 80405 trials. In the FIRE-3 trial, the OS and PFS, but not the ORR, of patients with LCC were superior to those of patients with RCC. LCC and RCC exhibit distinctive clinical features and epidemiology. However, we must further investigate the impact of these distinctive features and how they influence the differential oncologic outcomes.",
author = "Kwangmin Kim and Kim, {Young Wan} and Hongjin Shim and Kim, {Bo Ra} and Kwon, {Hye Youn}",
year = "2018",
month = "1",
day = "1",
language = "English",
volume = "23",
pages = "11--18",
journal = "Journal of B.U.ON.",
issn = "1107-0625",
publisher = "Balkan Union of Oncology",

}

Differences in clinical features and oncologic outcomes between metastatic right and left colon cancer. / Kim, Kwangmin; Kim, Young Wan; Shim, Hongjin; Kim, Bo Ra; Kwon, Hye Youn.

In: Journal of B.U.ON., Vol. 23, 01.01.2018, p. 11-18.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Differences in clinical features and oncologic outcomes between metastatic right and left colon cancer

AU - Kim, Kwangmin

AU - Kim, Young Wan

AU - Shim, Hongjin

AU - Kim, Bo Ra

AU - Kwon, Hye Youn

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Approximately 20% to 25% of patients with colorectal cancer (CRC) have distant organ metastasis at the time of initial diagnosis. The primary tumor location has been suggested as a prognostic factor for patients with metastatic CRC. In recent years, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has been brought into focus due to their different outcomes, prognoses, and clinical responses to chemotherapy. In this article we aimed to review the underlying differences between metastatic RCC and LCC in terms of epidemiology, clinical features, and oncologic outcomes. The outcomes of patients with left-sided tumors were better than those of patients with right-sided tumors in terms of overall survival (OS) and objective response rate (ORR) after treatment with chemotherapy + panitumumab in the PRIME and 20050181 trials. The outcomes of patients with LCC were better than those of patients with RCC in terms of OS, progression-free survival (PFS) and ORR after treatment with FOLFIRI + cetuximab in the CRYSTAL and CALGB 80405 trials. In the FIRE-3 trial, the OS and PFS, but not the ORR, of patients with LCC were superior to those of patients with RCC. LCC and RCC exhibit distinctive clinical features and epidemiology. However, we must further investigate the impact of these distinctive features and how they influence the differential oncologic outcomes.

AB - Approximately 20% to 25% of patients with colorectal cancer (CRC) have distant organ metastasis at the time of initial diagnosis. The primary tumor location has been suggested as a prognostic factor for patients with metastatic CRC. In recent years, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has been brought into focus due to their different outcomes, prognoses, and clinical responses to chemotherapy. In this article we aimed to review the underlying differences between metastatic RCC and LCC in terms of epidemiology, clinical features, and oncologic outcomes. The outcomes of patients with left-sided tumors were better than those of patients with right-sided tumors in terms of overall survival (OS) and objective response rate (ORR) after treatment with chemotherapy + panitumumab in the PRIME and 20050181 trials. The outcomes of patients with LCC were better than those of patients with RCC in terms of OS, progression-free survival (PFS) and ORR after treatment with FOLFIRI + cetuximab in the CRYSTAL and CALGB 80405 trials. In the FIRE-3 trial, the OS and PFS, but not the ORR, of patients with LCC were superior to those of patients with RCC. LCC and RCC exhibit distinctive clinical features and epidemiology. However, we must further investigate the impact of these distinctive features and how they influence the differential oncologic outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85057732496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057732496&partnerID=8YFLogxK

M3 - Review article

C2 - 30722106

AN - SCOPUS:85057732496

VL - 23

SP - 11

EP - 18

JO - Journal of B.U.ON.

JF - Journal of B.U.ON.

SN - 1107-0625

ER -