Differences in Prognostic Factors and Failure Patterns between Invasive Micropapillary Carcinoma and Carcinoma with Micropapillary Component Versus Invasive Ductal Carcinoma of the Breast: Retrospective Multicenter Case-Control Study (KROG 13-06)

Jeong Il Yu, Doo Ho Choi, Seung Jae Huh, Eun Yoon Cho, Kyubo Kim, Eui Kyu Chie, Sung W. Ha, In Ae Park, Sung Ja Ahn, Ji Shin Lee, Kyung Hwan Shin, Youngmee Kwon, Yong Bae Kim, Chang Ok Suh, Ja Seung Koo, Jin Hee Kim, Bae Gwon Jeong, In Ah Kim, Jong Hoon Lee, Won Park

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Abstract

Purpose We designed the present study to investigate differences in prognostic factors and failure patterns between patients with invasive micropapillary carcinoma or carcinoma with micropapillary component (IMPC) and randomly matched patients with invasive ductal carcinoma (IDC) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG). Materials and Methods This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011. Female patients who had undergone curative resection for breast cancer without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age (± 3 years), pathologic tumor and node stage, treatment method (surgery with or without radiotherapy), and period when surgery was performed (within 1 year) at the same institution. Results A total of 534 patients were analyzed. The median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in IDC (P <.001, P =.01, respectively). During the follow-up period, recurrences developed in 40 patients with IMPC (15.0%) and 21 with IDC (7.9%). Locoregional recurrence (LRR) developed in 22 patients with IMPC (8.2%) and 10 with IDC (3.7%). The rate of distant metastasis did not differ between the 2 groups (P =.52). LRR-free survival (P =.03) and recurrence-free survival (P =.007) were significantly different between the 2 groups, but overall survival was not (P =.67). Conclusion IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to IDC. Modification of the locoregional treatment modality might be needed in this pathologic subtype of breast cancer.

Original languageEnglish
Pages (from-to)353-361.e2
JournalClinical Breast Cancer
Volume15
Issue number5
DOIs
Publication statusPublished - 2015 Oct 1

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Carcinoma, Ductal, Breast
Radiation Oncology
Case-Control Studies
Ductal Carcinoma
Carcinoma
Recurrence
Survival
Breast Neoplasms
Multicenter Studies
Radiotherapy
Retrospective Studies
Neoplasm Metastasis
Drug Therapy
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yu, Jeong Il ; Choi, Doo Ho ; Huh, Seung Jae ; Cho, Eun Yoon ; Kim, Kyubo ; Chie, Eui Kyu ; Ha, Sung W. ; Park, In Ae ; Ahn, Sung Ja ; Lee, Ji Shin ; Shin, Kyung Hwan ; Kwon, Youngmee ; Kim, Yong Bae ; Suh, Chang Ok ; Koo, Ja Seung ; Kim, Jin Hee ; Jeong, Bae Gwon ; Kim, In Ah ; Lee, Jong Hoon ; Park, Won. / Differences in Prognostic Factors and Failure Patterns between Invasive Micropapillary Carcinoma and Carcinoma with Micropapillary Component Versus Invasive Ductal Carcinoma of the Breast : Retrospective Multicenter Case-Control Study (KROG 13-06). In: Clinical Breast Cancer. 2015 ; Vol. 15, No. 5. pp. 353-361.e2.
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title = "Differences in Prognostic Factors and Failure Patterns between Invasive Micropapillary Carcinoma and Carcinoma with Micropapillary Component Versus Invasive Ductal Carcinoma of the Breast: Retrospective Multicenter Case-Control Study (KROG 13-06)",
abstract = "Purpose We designed the present study to investigate differences in prognostic factors and failure patterns between patients with invasive micropapillary carcinoma or carcinoma with micropapillary component (IMPC) and randomly matched patients with invasive ductal carcinoma (IDC) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG). Materials and Methods This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011. Female patients who had undergone curative resection for breast cancer without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age (± 3 years), pathologic tumor and node stage, treatment method (surgery with or without radiotherapy), and period when surgery was performed (within 1 year) at the same institution. Results A total of 534 patients were analyzed. The median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in IDC (P <.001, P =.01, respectively). During the follow-up period, recurrences developed in 40 patients with IMPC (15.0{\%}) and 21 with IDC (7.9{\%}). Locoregional recurrence (LRR) developed in 22 patients with IMPC (8.2{\%}) and 10 with IDC (3.7{\%}). The rate of distant metastasis did not differ between the 2 groups (P =.52). LRR-free survival (P =.03) and recurrence-free survival (P =.007) were significantly different between the 2 groups, but overall survival was not (P =.67). Conclusion IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to IDC. Modification of the locoregional treatment modality might be needed in this pathologic subtype of breast cancer.",
author = "Yu, {Jeong Il} and Choi, {Doo Ho} and Huh, {Seung Jae} and Cho, {Eun Yoon} and Kyubo Kim and Chie, {Eui Kyu} and Ha, {Sung W.} and Park, {In Ae} and Ahn, {Sung Ja} and Lee, {Ji Shin} and Shin, {Kyung Hwan} and Youngmee Kwon and Kim, {Yong Bae} and Suh, {Chang Ok} and Koo, {Ja Seung} and Kim, {Jin Hee} and Jeong, {Bae Gwon} and Kim, {In Ah} and Lee, {Jong Hoon} and Won Park",
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Differences in Prognostic Factors and Failure Patterns between Invasive Micropapillary Carcinoma and Carcinoma with Micropapillary Component Versus Invasive Ductal Carcinoma of the Breast : Retrospective Multicenter Case-Control Study (KROG 13-06). / Yu, Jeong Il; Choi, Doo Ho; Huh, Seung Jae; Cho, Eun Yoon; Kim, Kyubo; Chie, Eui Kyu; Ha, Sung W.; Park, In Ae; Ahn, Sung Ja; Lee, Ji Shin; Shin, Kyung Hwan; Kwon, Youngmee; Kim, Yong Bae; Suh, Chang Ok; Koo, Ja Seung; Kim, Jin Hee; Jeong, Bae Gwon; Kim, In Ah; Lee, Jong Hoon; Park, Won.

In: Clinical Breast Cancer, Vol. 15, No. 5, 01.10.2015, p. 353-361.e2.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differences in Prognostic Factors and Failure Patterns between Invasive Micropapillary Carcinoma and Carcinoma with Micropapillary Component Versus Invasive Ductal Carcinoma of the Breast

T2 - Retrospective Multicenter Case-Control Study (KROG 13-06)

AU - Yu, Jeong Il

AU - Choi, Doo Ho

AU - Huh, Seung Jae

AU - Cho, Eun Yoon

AU - Kim, Kyubo

AU - Chie, Eui Kyu

AU - Ha, Sung W.

AU - Park, In Ae

AU - Ahn, Sung Ja

AU - Lee, Ji Shin

AU - Shin, Kyung Hwan

AU - Kwon, Youngmee

AU - Kim, Yong Bae

AU - Suh, Chang Ok

AU - Koo, Ja Seung

AU - Kim, Jin Hee

AU - Jeong, Bae Gwon

AU - Kim, In Ah

AU - Lee, Jong Hoon

AU - Park, Won

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Purpose We designed the present study to investigate differences in prognostic factors and failure patterns between patients with invasive micropapillary carcinoma or carcinoma with micropapillary component (IMPC) and randomly matched patients with invasive ductal carcinoma (IDC) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG). Materials and Methods This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011. Female patients who had undergone curative resection for breast cancer without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age (± 3 years), pathologic tumor and node stage, treatment method (surgery with or without radiotherapy), and period when surgery was performed (within 1 year) at the same institution. Results A total of 534 patients were analyzed. The median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in IDC (P <.001, P =.01, respectively). During the follow-up period, recurrences developed in 40 patients with IMPC (15.0%) and 21 with IDC (7.9%). Locoregional recurrence (LRR) developed in 22 patients with IMPC (8.2%) and 10 with IDC (3.7%). The rate of distant metastasis did not differ between the 2 groups (P =.52). LRR-free survival (P =.03) and recurrence-free survival (P =.007) were significantly different between the 2 groups, but overall survival was not (P =.67). Conclusion IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to IDC. Modification of the locoregional treatment modality might be needed in this pathologic subtype of breast cancer.

AB - Purpose We designed the present study to investigate differences in prognostic factors and failure patterns between patients with invasive micropapillary carcinoma or carcinoma with micropapillary component (IMPC) and randomly matched patients with invasive ductal carcinoma (IDC) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG). Materials and Methods This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011. Female patients who had undergone curative resection for breast cancer without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age (± 3 years), pathologic tumor and node stage, treatment method (surgery with or without radiotherapy), and period when surgery was performed (within 1 year) at the same institution. Results A total of 534 patients were analyzed. The median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in IDC (P <.001, P =.01, respectively). During the follow-up period, recurrences developed in 40 patients with IMPC (15.0%) and 21 with IDC (7.9%). Locoregional recurrence (LRR) developed in 22 patients with IMPC (8.2%) and 10 with IDC (3.7%). The rate of distant metastasis did not differ between the 2 groups (P =.52). LRR-free survival (P =.03) and recurrence-free survival (P =.007) were significantly different between the 2 groups, but overall survival was not (P =.67). Conclusion IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to IDC. Modification of the locoregional treatment modality might be needed in this pathologic subtype of breast cancer.

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U2 - 10.1016/j.clbc.2015.01.008

DO - 10.1016/j.clbc.2015.01.008

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