Differences regarding the molecular features and gut microbiota between right and left colon cancer

Kwangmin Kim, Ernes John T. Castro, Hongjin Shim, John Vincent G. Advincula, Young Wan Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalAnnals of Coloproctology
Volume34
Issue number6
DOIs
Publication statusPublished - 2018 Dec

Fingerprint

Colonic Neoplasms
Gastrointestinal Microbiome
Leptotrichia
Selenomonas
Fusobacterium
Prevotella
Peptostreptococcus
Escherichia
Chromosomal Instability
Microsatellite Instability
CpG Islands
Shigella
Patient Rights
Mutation Rate
Biofilms
Tumor Suppressor Genes
Oncogenes
Colorectal Neoplasms
Neoplasms
Phenotype

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kim, Kwangmin ; Castro, Ernes John T. ; Shim, Hongjin ; Advincula, John Vincent G. ; Kim, Young Wan. / Differences regarding the molecular features and gut microbiota between right and left colon cancer. In: Annals of Coloproctology. 2018 ; Vol. 34, No. 6. pp. 292-298.
@article{3d5d238b5bc342f480b67ba1b53e949b,
title = "Differences regarding the molecular features and gut microbiota between right and left colon cancer",
abstract = "For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75{\%} of LCC patients and 30{\%} of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.",
author = "Kwangmin Kim and Castro, {Ernes John T.} and Hongjin Shim and Advincula, {John Vincent G.} and Kim, {Young Wan}",
year = "2018",
month = "12",
doi = "10.3393/ac.2018.12.17",
language = "English",
volume = "34",
pages = "292--298",
journal = "Annals of Coloproctology",
issn = "2287-9714",
publisher = "Korean Society of Coloproctology",
number = "6",

}

Differences regarding the molecular features and gut microbiota between right and left colon cancer. / Kim, Kwangmin; Castro, Ernes John T.; Shim, Hongjin; Advincula, John Vincent G.; Kim, Young Wan.

In: Annals of Coloproctology, Vol. 34, No. 6, 12.2018, p. 292-298.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differences regarding the molecular features and gut microbiota between right and left colon cancer

AU - Kim, Kwangmin

AU - Castro, Ernes John T.

AU - Shim, Hongjin

AU - Advincula, John Vincent G.

AU - Kim, Young Wan

PY - 2018/12

Y1 - 2018/12

N2 - For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.

AB - For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.

UR - http://www.scopus.com/inward/record.url?scp=85059641488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059641488&partnerID=8YFLogxK

U2 - 10.3393/ac.2018.12.17

DO - 10.3393/ac.2018.12.17

M3 - Article

AN - SCOPUS:85059641488

VL - 34

SP - 292

EP - 298

JO - Annals of Coloproctology

JF - Annals of Coloproctology

SN - 2287-9714

IS - 6

ER -