Different biological behaviors in left-sided pancreatic cancer according to Yonsei criteria: Proposal of a modified Yonsei criteria score

Seoung Yoon Rho, Mijin Yun, Chang Moo Kang, Sung Hwan Lee, Ho Kyoung Hwang, Woo Jung Lee

Research output: Contribution to journalArticle

Abstract

Background/objectives: Our institutional experience has demonstrated that bloodless and margin-negative resection is the most potent prognostic factor in treating left-sided pancreatic cancer and we developed selection guideline. The Yonsei criteria (YC) is selection criteria for oncologically safe and effective resection of left-sided pancreatic cancer by a minimally invasive approach. In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters. Methods: From January 2000 to December 2015, 105 patients underwent distal pancreatectomy for left-sided pancreatic cancer. The medical records of the patients were retrospectively reviewed. Results: Among clinically and pathologically detectable parameters to predict tumor conditions, radiologically determined tumor size (p = 0.080) and SUV max (p = 0.086) were identified as predictors of early tumor recurrence with marginal significance. Among them, 20% of the patients with YC were identified as having the most favoring tumor condition, with an modified YC score of 3. The patient group with the lowest mYC score was found to have a very long disease-free survival time, with a mean of 108 months, which was statistically different from those with other mYC scores (mYC score = 4, mean 47.1 months [95% CI: 27.8–69.5] vs. mYC score = 5, mean 36.7 months [95% CI: 12.7–60.7], vs. mYC score = 6, mean 10.7 months [95% CI: 3.9–17.4]). Conclusions: Modified Yonsei criteria score can predict long-term survival in resected left-sided pancreatic cancer. And patients within YC with a mYC score = 3 could have a favorable survival outcome.

Original languageEnglish
Pages (from-to)990-995
Number of pages6
JournalPancreatology
Volume18
Issue number8
DOIs
Publication statusPublished - 2018 Dec

Fingerprint

Pancreatic Neoplasms
Survival
Neoplasms
Pancreatectomy
Patient Selection
Disease-Free Survival
Medical Records
Guidelines
Recurrence

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

Cite this

Rho, Seoung Yoon ; Yun, Mijin ; Kang, Chang Moo ; Lee, Sung Hwan ; Hwang, Ho Kyoung ; Lee, Woo Jung. / Different biological behaviors in left-sided pancreatic cancer according to Yonsei criteria : Proposal of a modified Yonsei criteria score. In: Pancreatology. 2018 ; Vol. 18, No. 8. pp. 990-995.
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abstract = "Background/objectives: Our institutional experience has demonstrated that bloodless and margin-negative resection is the most potent prognostic factor in treating left-sided pancreatic cancer and we developed selection guideline. The Yonsei criteria (YC) is selection criteria for oncologically safe and effective resection of left-sided pancreatic cancer by a minimally invasive approach. In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters. Methods: From January 2000 to December 2015, 105 patients underwent distal pancreatectomy for left-sided pancreatic cancer. The medical records of the patients were retrospectively reviewed. Results: Among clinically and pathologically detectable parameters to predict tumor conditions, radiologically determined tumor size (p = 0.080) and SUV max (p = 0.086) were identified as predictors of early tumor recurrence with marginal significance. Among them, 20{\%} of the patients with YC were identified as having the most favoring tumor condition, with an modified YC score of 3. The patient group with the lowest mYC score was found to have a very long disease-free survival time, with a mean of 108 months, which was statistically different from those with other mYC scores (mYC score = 4, mean 47.1 months [95{\%} CI: 27.8–69.5] vs. mYC score = 5, mean 36.7 months [95{\%} CI: 12.7–60.7], vs. mYC score = 6, mean 10.7 months [95{\%} CI: 3.9–17.4]). Conclusions: Modified Yonsei criteria score can predict long-term survival in resected left-sided pancreatic cancer. And patients within YC with a mYC score = 3 could have a favorable survival outcome.",
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Different biological behaviors in left-sided pancreatic cancer according to Yonsei criteria : Proposal of a modified Yonsei criteria score. / Rho, Seoung Yoon; Yun, Mijin; Kang, Chang Moo; Lee, Sung Hwan; Hwang, Ho Kyoung; Lee, Woo Jung.

In: Pancreatology, Vol. 18, No. 8, 12.2018, p. 990-995.

Research output: Contribution to journalArticle

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T1 - Different biological behaviors in left-sided pancreatic cancer according to Yonsei criteria

T2 - Proposal of a modified Yonsei criteria score

AU - Rho, Seoung Yoon

AU - Yun, Mijin

AU - Kang, Chang Moo

AU - Lee, Sung Hwan

AU - Hwang, Ho Kyoung

AU - Lee, Woo Jung

PY - 2018/12

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N2 - Background/objectives: Our institutional experience has demonstrated that bloodless and margin-negative resection is the most potent prognostic factor in treating left-sided pancreatic cancer and we developed selection guideline. The Yonsei criteria (YC) is selection criteria for oncologically safe and effective resection of left-sided pancreatic cancer by a minimally invasive approach. In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters. Methods: From January 2000 to December 2015, 105 patients underwent distal pancreatectomy for left-sided pancreatic cancer. The medical records of the patients were retrospectively reviewed. Results: Among clinically and pathologically detectable parameters to predict tumor conditions, radiologically determined tumor size (p = 0.080) and SUV max (p = 0.086) were identified as predictors of early tumor recurrence with marginal significance. Among them, 20% of the patients with YC were identified as having the most favoring tumor condition, with an modified YC score of 3. The patient group with the lowest mYC score was found to have a very long disease-free survival time, with a mean of 108 months, which was statistically different from those with other mYC scores (mYC score = 4, mean 47.1 months [95% CI: 27.8–69.5] vs. mYC score = 5, mean 36.7 months [95% CI: 12.7–60.7], vs. mYC score = 6, mean 10.7 months [95% CI: 3.9–17.4]). Conclusions: Modified Yonsei criteria score can predict long-term survival in resected left-sided pancreatic cancer. And patients within YC with a mYC score = 3 could have a favorable survival outcome.

AB - Background/objectives: Our institutional experience has demonstrated that bloodless and margin-negative resection is the most potent prognostic factor in treating left-sided pancreatic cancer and we developed selection guideline. The Yonsei criteria (YC) is selection criteria for oncologically safe and effective resection of left-sided pancreatic cancer by a minimally invasive approach. In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters. Methods: From January 2000 to December 2015, 105 patients underwent distal pancreatectomy for left-sided pancreatic cancer. The medical records of the patients were retrospectively reviewed. Results: Among clinically and pathologically detectable parameters to predict tumor conditions, radiologically determined tumor size (p = 0.080) and SUV max (p = 0.086) were identified as predictors of early tumor recurrence with marginal significance. Among them, 20% of the patients with YC were identified as having the most favoring tumor condition, with an modified YC score of 3. The patient group with the lowest mYC score was found to have a very long disease-free survival time, with a mean of 108 months, which was statistically different from those with other mYC scores (mYC score = 4, mean 47.1 months [95% CI: 27.8–69.5] vs. mYC score = 5, mean 36.7 months [95% CI: 12.7–60.7], vs. mYC score = 6, mean 10.7 months [95% CI: 3.9–17.4]). Conclusions: Modified Yonsei criteria score can predict long-term survival in resected left-sided pancreatic cancer. And patients within YC with a mYC score = 3 could have a favorable survival outcome.

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