Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on Parkinsonian motor deficits and freezing of gait

Hyoung Lyoo Chul, Sargo Aalto, Juha O. Rinne, Ook Lee Ki, Hun Oh Seung, Woo Chang Jin, Sik Lee Myung

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [18F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.

Original languageEnglish
Pages (from-to)2176-2182
Number of pages7
JournalMovement Disorders
Volume22
Issue number15
DOIs
Publication statusPublished - 2007 Nov 15

Fingerprint

Subthalamic Nucleus
Gait
Freezing
Levodopa
Gyrus Cinguli
Deoxyglucose
Motor Cortex
Brain
Prefrontal Cortex
Positron-Emission Tomography
Parkinson Disease
Glucose

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Chul, Hyoung Lyoo ; Aalto, Sargo ; Rinne, Juha O. ; Ki, Ook Lee ; Seung, Hun Oh ; Jin, Woo Chang ; Myung, Sik Lee. / Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on Parkinsonian motor deficits and freezing of gait. In: Movement Disorders. 2007 ; Vol. 22, No. 15. pp. 2176-2182.
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abstract = "Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [18F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3{\%} and the mFOG scores by 56.6{\%}. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.",
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Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on Parkinsonian motor deficits and freezing of gait. / Chul, Hyoung Lyoo; Aalto, Sargo; Rinne, Juha O.; Ki, Ook Lee; Seung, Hun Oh; Jin, Woo Chang; Myung, Sik Lee.

In: Movement Disorders, Vol. 22, No. 15, 15.11.2007, p. 2176-2182.

Research output: Contribution to journalArticle

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AU - Chul, Hyoung Lyoo

AU - Aalto, Sargo

AU - Rinne, Juha O.

AU - Ki, Ook Lee

AU - Seung, Hun Oh

AU - Jin, Woo Chang

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