Different expression patterns of MMP-2 and MMP-9 in breast cancer

Sun Young Rha, Woo Ick Yang, Joo Hang Kim, Jae Kyung Roh, Jin Sik Min, Kyong Sik Lee, Byung Soo Kim, Hyun Cheol Chung

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27 Citations (Scopus)

Abstract

Among the many biological characteristics of cancer, the matrix metalloproteinase (MMPs) is essential for tumor invasion and metastasis. The relationship between MMP-2 and MMP-9 according to tumor progression has not been studied yet. We evaluated the synchronous expression and activation rate of MMP-2 and MMP-9 in breast cancer tissues and compared them to the clinical parameters in order to determine the clinical significance of MMPs and the possibilities of using them as a therapeutic target. The activity of MMPs was evaluated in 121 breast cancer tissues using zymography and the area of activation was calculated by computer-assisted densitometry in comparison to the activity of a positive control (HT-1080). In 121 tumor tissues, 32 (26.4%) did not express any form of MMPs and 19 (15.7%) showed both expression of MMP-2 and MMP-9. We observed that only one tissue expressed MMP-9 alone, while MMP-2 alone was expressed in 69 tissues. In 88 patients with MMP-2 and/or MMP-9 expression, we were unable to observe any correlation between the activity of MMPs expression or activation rate and the clinical parameters. But MMP-2 and MMP-9 activity increased according to T factor. Rapid production of MMP-9 occurred from T2 (p=0.046), while that of MMP-2 occurred from T3 (p=0.004). In conclusion, MMPs activity was organ specific. The major MMPs in breast cancer was MMP-2 and MMPs activity was different with tumor progression. When MMPs are a specific therapeutic target, we should use different inhibitors according to tumor size, in patients at the same stage.

Original languageEnglish
Pages (from-to)875-879
Number of pages5
JournalOncology Reports
Volume5
Issue number4
Publication statusPublished - 1998 Jun 23

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Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Breast Neoplasms
Neoplasms
Densitometry
Neoplasm Metastasis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Rha, S. Y., Yang, W. I., Kim, J. H., Roh, J. K., Min, J. S., Lee, K. S., ... Chung, H. C. (1998). Different expression patterns of MMP-2 and MMP-9 in breast cancer. Oncology Reports, 5(4), 875-879.
Rha, Sun Young ; Yang, Woo Ick ; Kim, Joo Hang ; Roh, Jae Kyung ; Min, Jin Sik ; Lee, Kyong Sik ; Kim, Byung Soo ; Chung, Hyun Cheol. / Different expression patterns of MMP-2 and MMP-9 in breast cancer. In: Oncology Reports. 1998 ; Vol. 5, No. 4. pp. 875-879.
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Rha, SY, Yang, WI, Kim, JH, Roh, JK, Min, JS, Lee, KS, Kim, BS & Chung, HC 1998, 'Different expression patterns of MMP-2 and MMP-9 in breast cancer', Oncology Reports, vol. 5, no. 4, pp. 875-879.

Different expression patterns of MMP-2 and MMP-9 in breast cancer. / Rha, Sun Young; Yang, Woo Ick; Kim, Joo Hang; Roh, Jae Kyung; Min, Jin Sik; Lee, Kyong Sik; Kim, Byung Soo; Chung, Hyun Cheol.

In: Oncology Reports, Vol. 5, No. 4, 23.06.1998, p. 875-879.

Research output: Contribution to journalArticle

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AU - Rha, Sun Young

AU - Yang, Woo Ick

AU - Kim, Joo Hang

AU - Roh, Jae Kyung

AU - Min, Jin Sik

AU - Lee, Kyong Sik

AU - Kim, Byung Soo

AU - Chung, Hyun Cheol

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Rha SY, Yang WI, Kim JH, Roh JK, Min JS, Lee KS et al. Different expression patterns of MMP-2 and MMP-9 in breast cancer. Oncology Reports. 1998 Jun 23;5(4):875-879.