Different expression patterns of MMP-2 and MMP-9 in breast cancer

SunYoung Rha, Woo Ick Yang, Joo Hang Kim, Jae Kyung Roh, Jin Sik Min, Kyong Sik Lee, Byung Soo Kim, Hyuncheol Chung

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27 Citations (Scopus)

Abstract

Among the many biological characteristics of cancer, the matrix metalloproteinase (MMPs) is essential for tumor invasion and metastasis. The relationship between MMP-2 and MMP-9 according to tumor progression has not been studied yet. We evaluated the synchronous expression and activation rate of MMP-2 and MMP-9 in breast cancer tissues and compared them to the clinical parameters in order to determine the clinical significance of MMPs and the possibilities of using them as a therapeutic target. The activity of MMPs was evaluated in 121 breast cancer tissues using zymography and the area of activation was calculated by computer-assisted densitometry in comparison to the activity of a positive control (HT-1080). In 121 tumor tissues, 32 (26.4%) did not express any form of MMPs and 19 (15.7%) showed both expression of MMP-2 and MMP-9. We observed that only one tissue expressed MMP-9 alone, while MMP-2 alone was expressed in 69 tissues. In 88 patients with MMP-2 and/or MMP-9 expression, we were unable to observe any correlation between the activity of MMPs expression or activation rate and the clinical parameters. But MMP-2 and MMP-9 activity increased according to T factor. Rapid production of MMP-9 occurred from T2 (p=0.046), while that of MMP-2 occurred from T3 (p=0.004). In conclusion, MMPs activity was organ specific. The major MMPs in breast cancer was MMP-2 and MMPs activity was different with tumor progression. When MMPs are a specific therapeutic target, we should use different inhibitors according to tumor size, in patients at the same stage.

Original languageEnglish
Pages (from-to)875-879
Number of pages5
JournalOncology Reports
Volume5
Issue number4
Publication statusPublished - 1998 Jun 23

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Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Breast Neoplasms
Neoplasms
Densitometry
Neoplasm Metastasis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Rha, S., Yang, W. I., Kim, J. H., Roh, J. K., Min, J. S., Lee, K. S., ... Chung, H. (1998). Different expression patterns of MMP-2 and MMP-9 in breast cancer. Oncology Reports, 5(4), 875-879.
Rha, SunYoung ; Yang, Woo Ick ; Kim, Joo Hang ; Roh, Jae Kyung ; Min, Jin Sik ; Lee, Kyong Sik ; Kim, Byung Soo ; Chung, Hyuncheol. / Different expression patterns of MMP-2 and MMP-9 in breast cancer. In: Oncology Reports. 1998 ; Vol. 5, No. 4. pp. 875-879.
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Rha, S, Yang, WI, Kim, JH, Roh, JK, Min, JS, Lee, KS, Kim, BS & Chung, H 1998, 'Different expression patterns of MMP-2 and MMP-9 in breast cancer', Oncology Reports, vol. 5, no. 4, pp. 875-879.

Different expression patterns of MMP-2 and MMP-9 in breast cancer. / Rha, SunYoung; Yang, Woo Ick; Kim, Joo Hang; Roh, Jae Kyung; Min, Jin Sik; Lee, Kyong Sik; Kim, Byung Soo; Chung, Hyuncheol.

In: Oncology Reports, Vol. 5, No. 4, 23.06.1998, p. 875-879.

Research output: Contribution to journalArticle

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AU - Rha, SunYoung

AU - Yang, Woo Ick

AU - Kim, Joo Hang

AU - Roh, Jae Kyung

AU - Min, Jin Sik

AU - Lee, Kyong Sik

AU - Kim, Byung Soo

AU - Chung, Hyuncheol

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Rha S, Yang WI, Kim JH, Roh JK, Min JS, Lee KS et al. Different expression patterns of MMP-2 and MMP-9 in breast cancer. Oncology Reports. 1998 Jun 23;5(4):875-879.