Different patterns of β-amyloid deposition in patients with Alzheimer's disease according to the presence of mild parkinsonism

Seok Jong Chung, Sangwon Lee, Han Soo Yoo, Kyoung Won Baik, Hye Sun Lee, Jin Ho Jung, Yonghoon Choi, Ji Man Hong, Yun Joong Kim, Byoung Seok Ye, Young H. Sohn, Mijin Yun, Phil Hyu Lee

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to compare the patterns of β-amyloid deposition between patients with early-stage Alzheimer's disease (AD) with mild parkinsonism and those without parkinsonism. Sixty-one patients with early-stage AD (Clinical Dementia Rating [CDR], 0.5 or 1) who underwent 18F-florbetaben (18F-FBB) PET scans were enrolled. We performed comparative analyses of regional FBB uptake in the frontal, parietal, lateral temporal, medial temporal, occipital, anterior cingulate, and posterior cingulate cortices and in the precuneus, striatum, and thalamus between AD patients with mild parkinsonism (AD-p+; n = 23) and those without parkinsonism (AD-p−; n = 38). There was no significant difference in age, sex, years of education, Mini-Mental State Examination score, and white matter hyperintensity severity between groups. The AD-p+ group had lower composite scores in frontal/executive function domain than the AD-p− group. The AD-p+ group had a higher FBB uptake in the occipital cortex, but not in other cortical regions, than the AD-p− group. Our findings suggest that additional β-amyloid deposition in the occipital region is associated with mild parkinsonism in early-stage AD.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalNeurobiology of Aging
Volume101
DOIs
Publication statusPublished - 2021 May

Bibliographical note

Funding Information:
This research was supported by a grant from the Korea Health Technology R&D Project through the Korean Healthy Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C1118).

Publisher Copyright:
© 2021

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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