Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study

Jung Sun Kim; Chunyu Fan; Donghoon Choi; Ik Kyung Jang; Jung Myung Lee; Tae Hoon Kim; Sang Min Park; Sung Il Paik; Young Guk Ko; Myeong Ki Hong; Yangsoo Jang; Namsik Chung

doi:10.1016/j.ijcard.2009.07.012

Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study

Jung Sun Kim, Chunyu Fan, Donghoon Choi, Ik Kyung Jang, Jung Myung Lee, Tae Hoon Kim, Sang Min Park, Sung Il Paik, Young Guk Ko, Myeong Ki Hong, Yangsoo Jang, Namsik Chung

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Background: Acute coronary syndrome (ACS) is an independent risk factor for late stent thrombosis which might be related to the impaired vascular healing after drug-eluting stent (DES) due to the disruption of plaques and thrombus formation. Therefore, we investigated the vascular response after various DES implantations between ACS and stable angina pectoris (SAP) using optical coherence tomography (OCT). Methods: Ninety-one patients [49 ACS: 20 sirolimus-eluting (SES), 12 paclitaxel-eluting (PES) and 17 zotarolimus eluting stent (ZES) and 42 SAP: 15 SES, 12 PES and 15 ZES] underwent OCT at 9 months after stent implantation. Neointimal coverage and malapposition were evaluated in 21,939 struts in 2269-mm stented segments. Results: In the ACS group, the incidence of uncovered and malapposed struts was significantly higher (8.9 ± 13.7 vs 2.9 ± 6.2%, p = 0.01 and 2.2 ± 5.6 vs 0.5 ± 2.0%, p = 0.02). Among the three DESs tested, SES showed a significantly higher rate of uncovered struts in the ACS group (17.3 ± 13.4 vs 4.4 ± 6.2%, p = 0.003). PES had a trend toward higher rate of uncovered and malapposed struts in the ACS groups (6.7 ± 7.6 vs 4.0 ± 9.0%, p = 0.13) while ZES was similar in both groups. Conclusion: The patterns of neointimal coverage and malapposition at 9 months after DES implantation were different between ACS and SAP, and variable among the DES type between two groups. Therefore, the present study suggests that vascular response after DES implantation might be influenced by both clinical presentation and type of DES.

Original language	English
Pages (from-to)	341-346
Number of pages	6
Journal	International Journal of Cardiology
Volume	146
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2009.07.012
Publication status	Published - 2011 Feb 3

Bibliographical note

Funding Information:
The authors thank Nam Wook Hur, Ph D at the Medical Research Support Section of Yonsei University for statistical support. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [30] .

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.ijcard.2009.07.012

Cite this

Kim, J. S., Fan, C., Choi, D., Jang, I. K., Lee, J. M., Kim, T. H., Park, S. M., Paik, S. I., Ko, Y. G., Hong, M. K., Jang, Y., & Chung, N. (2011). Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study. International Journal of Cardiology, 146(3), 341-346. https://doi.org/10.1016/j.ijcard.2009.07.012

@article{704dc2e9dec941b482868b7e9dba9a00,

title = "Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study",

abstract = "Background: Acute coronary syndrome (ACS) is an independent risk factor for late stent thrombosis which might be related to the impaired vascular healing after drug-eluting stent (DES) due to the disruption of plaques and thrombus formation. Therefore, we investigated the vascular response after various DES implantations between ACS and stable angina pectoris (SAP) using optical coherence tomography (OCT). Methods: Ninety-one patients [49 ACS: 20 sirolimus-eluting (SES), 12 paclitaxel-eluting (PES) and 17 zotarolimus eluting stent (ZES) and 42 SAP: 15 SES, 12 PES and 15 ZES] underwent OCT at 9 months after stent implantation. Neointimal coverage and malapposition were evaluated in 21,939 struts in 2269-mm stented segments. Results: In the ACS group, the incidence of uncovered and malapposed struts was significantly higher (8.9 ± 13.7 vs 2.9 ± 6.2%, p = 0.01 and 2.2 ± 5.6 vs 0.5 ± 2.0%, p = 0.02). Among the three DESs tested, SES showed a significantly higher rate of uncovered struts in the ACS group (17.3 ± 13.4 vs 4.4 ± 6.2%, p = 0.003). PES had a trend toward higher rate of uncovered and malapposed struts in the ACS groups (6.7 ± 7.6 vs 4.0 ± 9.0%, p = 0.13) while ZES was similar in both groups. Conclusion: The patterns of neointimal coverage and malapposition at 9 months after DES implantation were different between ACS and SAP, and variable among the DES type between two groups. Therefore, the present study suggests that vascular response after DES implantation might be influenced by both clinical presentation and type of DES.",

author = "Kim, {Jung Sun} and Chunyu Fan and Donghoon Choi and Jang, {Ik Kyung} and Lee, {Jung Myung} and Kim, {Tae Hoon} and Park, {Sang Min} and Paik, {Sung Il} and Ko, {Young Guk} and Hong, {Myeong Ki} and Yangsoo Jang and Namsik Chung",

note = "Funding Information: The authors thank Nam Wook Hur, Ph D at the Medical Research Support Section of Yonsei University for statistical support. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [30] . ",

year = "2011",

month = feb,

day = "3",

doi = "10.1016/j.ijcard.2009.07.012",

language = "English",

volume = "146",

pages = "341--346",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

Kim, JS, Fan, C, Choi, D, Jang, IK, Lee, JM, Kim, TH, Park, SM, Paik, SI, Ko, YG, Hong, MK , Jang, Y & Chung, N 2011, 'Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study', International Journal of Cardiology, vol. 146, no. 3, pp. 341-346. https://doi.org/10.1016/j.ijcard.2009.07.012

Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study. / Kim, Jung Sun; Fan, Chunyu; Choi, Donghoon et al.

In: International Journal of Cardiology, Vol. 146, No. 3, 03.02.2011, p. 341-346.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study

AU - Kim, Jung Sun

AU - Fan, Chunyu

AU - Choi, Donghoon

AU - Jang, Ik Kyung

AU - Lee, Jung Myung

AU - Kim, Tae Hoon

AU - Park, Sang Min

AU - Paik, Sung Il

AU - Ko, Young Guk

AU - Hong, Myeong Ki

AU - Jang, Yangsoo

AU - Chung, Namsik

N1 - Funding Information: The authors thank Nam Wook Hur, Ph D at the Medical Research Support Section of Yonsei University for statistical support. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [30] .

PY - 2011/2/3

Y1 - 2011/2/3

N2 - Background: Acute coronary syndrome (ACS) is an independent risk factor for late stent thrombosis which might be related to the impaired vascular healing after drug-eluting stent (DES) due to the disruption of plaques and thrombus formation. Therefore, we investigated the vascular response after various DES implantations between ACS and stable angina pectoris (SAP) using optical coherence tomography (OCT). Methods: Ninety-one patients [49 ACS: 20 sirolimus-eluting (SES), 12 paclitaxel-eluting (PES) and 17 zotarolimus eluting stent (ZES) and 42 SAP: 15 SES, 12 PES and 15 ZES] underwent OCT at 9 months after stent implantation. Neointimal coverage and malapposition were evaluated in 21,939 struts in 2269-mm stented segments. Results: In the ACS group, the incidence of uncovered and malapposed struts was significantly higher (8.9 ± 13.7 vs 2.9 ± 6.2%, p = 0.01 and 2.2 ± 5.6 vs 0.5 ± 2.0%, p = 0.02). Among the three DESs tested, SES showed a significantly higher rate of uncovered struts in the ACS group (17.3 ± 13.4 vs 4.4 ± 6.2%, p = 0.003). PES had a trend toward higher rate of uncovered and malapposed struts in the ACS groups (6.7 ± 7.6 vs 4.0 ± 9.0%, p = 0.13) while ZES was similar in both groups. Conclusion: The patterns of neointimal coverage and malapposition at 9 months after DES implantation were different between ACS and SAP, and variable among the DES type between two groups. Therefore, the present study suggests that vascular response after DES implantation might be influenced by both clinical presentation and type of DES.

AB - Background: Acute coronary syndrome (ACS) is an independent risk factor for late stent thrombosis which might be related to the impaired vascular healing after drug-eluting stent (DES) due to the disruption of plaques and thrombus formation. Therefore, we investigated the vascular response after various DES implantations between ACS and stable angina pectoris (SAP) using optical coherence tomography (OCT). Methods: Ninety-one patients [49 ACS: 20 sirolimus-eluting (SES), 12 paclitaxel-eluting (PES) and 17 zotarolimus eluting stent (ZES) and 42 SAP: 15 SES, 12 PES and 15 ZES] underwent OCT at 9 months after stent implantation. Neointimal coverage and malapposition were evaluated in 21,939 struts in 2269-mm stented segments. Results: In the ACS group, the incidence of uncovered and malapposed struts was significantly higher (8.9 ± 13.7 vs 2.9 ± 6.2%, p = 0.01 and 2.2 ± 5.6 vs 0.5 ± 2.0%, p = 0.02). Among the three DESs tested, SES showed a significantly higher rate of uncovered struts in the ACS group (17.3 ± 13.4 vs 4.4 ± 6.2%, p = 0.003). PES had a trend toward higher rate of uncovered and malapposed struts in the ACS groups (6.7 ± 7.6 vs 4.0 ± 9.0%, p = 0.13) while ZES was similar in both groups. Conclusion: The patterns of neointimal coverage and malapposition at 9 months after DES implantation were different between ACS and SAP, and variable among the DES type between two groups. Therefore, the present study suggests that vascular response after DES implantation might be influenced by both clinical presentation and type of DES.

UR - http://www.scopus.com/inward/record.url?scp=78951483028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78951483028&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2009.07.012

DO - 10.1016/j.ijcard.2009.07.012

M3 - Article

C2 - 19709765

AN - SCOPUS:78951483028

SN - 0167-5273

VL - 146

SP - 341

EP - 346

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 3

ER -

Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this