Different subtypes of epithelioid sarcoma and their clinical implication

long-term multi-institutional experience with a rare sarcoma

Chan Kim, Kwai Han Yoo, Min Hwan Kim, Hong Jae Chon, Soon Il Lee, Hyo Jin Lee, Sujin Koh, Ha Yeon Lee, Hye Ran Lee, Kyung Sik Kim, Youngdeuk Choi, SunYoung Rha, Su Jin Lee, Hyo Song Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Epithelioid sarcoma (ES) is a very rare soft-tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio- and chemotherapy in ES. Fifty-five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty-six (84%) patients underwent surgical resection of ES, and among them, 27 experienced recurrence. In these patients, resection margin status and adjuvant radiotherapy were independent prognostic factors for longer recurrence-free survival (RFS), while adjuvant chemotherapy did not influence RFS. Twenty-two (40%) patients received palliative chemotherapy for metastatic or recurrent ES, and in these patients, palliative chemotherapy was the only independent prognostic factor for longer overall survival. Intriguingly, the clinical benefit of radio- and chemotherapy was observable only in proximal ES, but not in extremity ES, indicating that subtypes of ES might respond to radio- or chemotherapy differently. Proximal ES seems to benefits more from active anticancer treatment than conventional extremity ES. The aggressive characteristics of proximal ES could be overcome with an optimal multimodal treatment.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalAPMIS
Volume125
Issue number3
DOIs
Publication statusPublished - 2017 Mar 1

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Sarcoma
Drug Therapy
Recurrence
Radiotherapy
Survival
Extremities
Combined Modality Therapy
Adjuvant Radiotherapy
Adjuvant Chemotherapy
Tertiary Care Centers
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Kim, Chan ; Yoo, Kwai Han ; Kim, Min Hwan ; Chon, Hong Jae ; Lee, Soon Il ; Lee, Hyo Jin ; Koh, Sujin ; Lee, Ha Yeon ; Lee, Hye Ran ; Kim, Kyung Sik ; Choi, Youngdeuk ; Rha, SunYoung ; Lee, Su Jin ; Kim, Hyo Song. / Different subtypes of epithelioid sarcoma and their clinical implication : long-term multi-institutional experience with a rare sarcoma. In: APMIS. 2017 ; Vol. 125, No. 3. pp. 223-229.
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abstract = "Epithelioid sarcoma (ES) is a very rare soft-tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio- and chemotherapy in ES. Fifty-five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty-six (84{\%}) patients underwent surgical resection of ES, and among them, 27 experienced recurrence. In these patients, resection margin status and adjuvant radiotherapy were independent prognostic factors for longer recurrence-free survival (RFS), while adjuvant chemotherapy did not influence RFS. Twenty-two (40{\%}) patients received palliative chemotherapy for metastatic or recurrent ES, and in these patients, palliative chemotherapy was the only independent prognostic factor for longer overall survival. Intriguingly, the clinical benefit of radio- and chemotherapy was observable only in proximal ES, but not in extremity ES, indicating that subtypes of ES might respond to radio- or chemotherapy differently. Proximal ES seems to benefits more from active anticancer treatment than conventional extremity ES. The aggressive characteristics of proximal ES could be overcome with an optimal multimodal treatment.",
author = "Chan Kim and Yoo, {Kwai Han} and Kim, {Min Hwan} and Chon, {Hong Jae} and Lee, {Soon Il} and Lee, {Hyo Jin} and Sujin Koh and Lee, {Ha Yeon} and Lee, {Hye Ran} and Kim, {Kyung Sik} and Youngdeuk Choi and SunYoung Rha and Lee, {Su Jin} and Kim, {Hyo Song}",
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Kim, C, Yoo, KH, Kim, MH, Chon, HJ, Lee, SI, Lee, HJ, Koh, S, Lee, HY, Lee, HR, Kim, KS, Choi, Y, Rha, S, Lee, SJ & Kim, HS 2017, 'Different subtypes of epithelioid sarcoma and their clinical implication: long-term multi-institutional experience with a rare sarcoma', APMIS, vol. 125, no. 3, pp. 223-229. https://doi.org/10.1111/apm.12656

Different subtypes of epithelioid sarcoma and their clinical implication : long-term multi-institutional experience with a rare sarcoma. / Kim, Chan; Yoo, Kwai Han; Kim, Min Hwan; Chon, Hong Jae; Lee, Soon Il; Lee, Hyo Jin; Koh, Sujin; Lee, Ha Yeon; Lee, Hye Ran; Kim, Kyung Sik; Choi, Youngdeuk; Rha, SunYoung; Lee, Su Jin; Kim, Hyo Song.

In: APMIS, Vol. 125, No. 3, 01.03.2017, p. 223-229.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Different subtypes of epithelioid sarcoma and their clinical implication

T2 - long-term multi-institutional experience with a rare sarcoma

AU - Kim, Chan

AU - Yoo, Kwai Han

AU - Kim, Min Hwan

AU - Chon, Hong Jae

AU - Lee, Soon Il

AU - Lee, Hyo Jin

AU - Koh, Sujin

AU - Lee, Ha Yeon

AU - Lee, Hye Ran

AU - Kim, Kyung Sik

AU - Choi, Youngdeuk

AU - Rha, SunYoung

AU - Lee, Su Jin

AU - Kim, Hyo Song

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Epithelioid sarcoma (ES) is a very rare soft-tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio- and chemotherapy in ES. Fifty-five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty-six (84%) patients underwent surgical resection of ES, and among them, 27 experienced recurrence. In these patients, resection margin status and adjuvant radiotherapy were independent prognostic factors for longer recurrence-free survival (RFS), while adjuvant chemotherapy did not influence RFS. Twenty-two (40%) patients received palliative chemotherapy for metastatic or recurrent ES, and in these patients, palliative chemotherapy was the only independent prognostic factor for longer overall survival. Intriguingly, the clinical benefit of radio- and chemotherapy was observable only in proximal ES, but not in extremity ES, indicating that subtypes of ES might respond to radio- or chemotherapy differently. Proximal ES seems to benefits more from active anticancer treatment than conventional extremity ES. The aggressive characteristics of proximal ES could be overcome with an optimal multimodal treatment.

AB - Epithelioid sarcoma (ES) is a very rare soft-tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio- and chemotherapy in ES. Fifty-five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty-six (84%) patients underwent surgical resection of ES, and among them, 27 experienced recurrence. In these patients, resection margin status and adjuvant radiotherapy were independent prognostic factors for longer recurrence-free survival (RFS), while adjuvant chemotherapy did not influence RFS. Twenty-two (40%) patients received palliative chemotherapy for metastatic or recurrent ES, and in these patients, palliative chemotherapy was the only independent prognostic factor for longer overall survival. Intriguingly, the clinical benefit of radio- and chemotherapy was observable only in proximal ES, but not in extremity ES, indicating that subtypes of ES might respond to radio- or chemotherapy differently. Proximal ES seems to benefits more from active anticancer treatment than conventional extremity ES. The aggressive characteristics of proximal ES could be overcome with an optimal multimodal treatment.

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U2 - 10.1111/apm.12656

DO - 10.1111/apm.12656

M3 - Article

VL - 125

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