Differential antigen processing by dendritic cell subsets in vivo

Diana Dudziak, Alice O. Kamphorst, Gordon F. Heidkamp, Veit R. Buchholz, Christine Trumpfheller, Sayuri Yamazaki, Cheolho Cheong, Kang Liu, Han Woong Lee, Gyu Park Chae, Ralph M. Steinman, Michel C. Nussenzweig

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Abstract

Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8 + DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 3301 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalScience
Volume315
Issue number5808
DOIs
Publication statusPublished - 2007 Jan 5

All Science Journal Classification (ASJC) codes

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    Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H. W., Chae, G. P., Steinman, R. M., & Nussenzweig, M. C. (2007). Differential antigen processing by dendritic cell subsets in vivo. Science, 315(5808), 107-111. https://doi.org/10.1126/science.1136080