Differential association of body mass index on glycemic control in type 1 diabetes

Eun Young Lee, Yong Ho Lee, Sang Man Jin, Hae Kyung Yang, Chang Hee Jung, Cheol Young Park, Jae Hyoung Cho, Woo Je Lee, byungwan lee, Jae Hyeon Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: In contrast to type 2 diabetes, the association of body mass index (BMI) with glycemic control in type 1 diabetes (T1D) remains unclear. We investigated the relationship between BMI and average HbA1c levels in subjects with T1D. Method: In this multi-centre observational study, we analysed 719 subjects with T1D aged ≥18 years. Average HbA1c levels over 18 months and other clinical and laboratory parameters were evaluated. Results: The mean age and duration of diabetes at baseline were 41.5 ± 13.9 and 11.3 ± 8.7 years, respectively. A U-shaped correlation between BMI and 18-month average HbA1c levels was documented by a spline curve. Based on this finding, subjects were divided into three groups according to BMI (group I, <21; group II, 21–23; and group III, ≥23 kg/m2). In group I, the BMI negatively correlated with average HbA1c (r = −0.172, p = 0.011), while a positive relationship was observed (r = 0.162, p = 0.012) in group III. Average HbA1c levels were lower and the proportion of individuals with well-controlled glycemia (HbA1c <7%) were increased in the higher BMI tertile group among subjects with group I as well as in the lower BMI tertile group among subjects with group III BMI. After adjustment with additional covariates in the multiple regression model, these associations between BMI and HbA1c levels according to the different BMI ranges remained significant. Conclusions: In Korean subjects with T1D, an inverse relationship of BMI with HbA1c levels was observed in the low BMI group, while a positive correlation was shown in the high BMI group.

Original languageEnglish
Article numbere2815
JournalDiabetes/Metabolism Research and Reviews
Volume33
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Type 1 Diabetes Mellitus
Body Mass Index
Type 2 Diabetes Mellitus
Observational Studies

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lee, E. Y., Lee, Y. H., Jin, S. M., Yang, H. K., Jung, C. H., Park, C. Y., ... Kim, J. H. (2017). Differential association of body mass index on glycemic control in type 1 diabetes. Diabetes/Metabolism Research and Reviews, 33(1), [e2815]. https://doi.org/10.1002/dmrr.2815
Lee, Eun Young ; Lee, Yong Ho ; Jin, Sang Man ; Yang, Hae Kyung ; Jung, Chang Hee ; Park, Cheol Young ; Cho, Jae Hyoung ; Lee, Woo Je ; lee, byungwan ; Kim, Jae Hyeon. / Differential association of body mass index on glycemic control in type 1 diabetes. In: Diabetes/Metabolism Research and Reviews. 2017 ; Vol. 33, No. 1.
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abstract = "Background: In contrast to type 2 diabetes, the association of body mass index (BMI) with glycemic control in type 1 diabetes (T1D) remains unclear. We investigated the relationship between BMI and average HbA1c levels in subjects with T1D. Method: In this multi-centre observational study, we analysed 719 subjects with T1D aged ≥18 years. Average HbA1c levels over 18 months and other clinical and laboratory parameters were evaluated. Results: The mean age and duration of diabetes at baseline were 41.5 ± 13.9 and 11.3 ± 8.7 years, respectively. A U-shaped correlation between BMI and 18-month average HbA1c levels was documented by a spline curve. Based on this finding, subjects were divided into three groups according to BMI (group I, <21; group II, 21–23; and group III, ≥23 kg/m2). In group I, the BMI negatively correlated with average HbA1c (r = −0.172, p = 0.011), while a positive relationship was observed (r = 0.162, p = 0.012) in group III. Average HbA1c levels were lower and the proportion of individuals with well-controlled glycemia (HbA1c <7{\%}) were increased in the higher BMI tertile group among subjects with group I as well as in the lower BMI tertile group among subjects with group III BMI. After adjustment with additional covariates in the multiple regression model, these associations between BMI and HbA1c levels according to the different BMI ranges remained significant. Conclusions: In Korean subjects with T1D, an inverse relationship of BMI with HbA1c levels was observed in the low BMI group, while a positive correlation was shown in the high BMI group.",
author = "Lee, {Eun Young} and Lee, {Yong Ho} and Jin, {Sang Man} and Yang, {Hae Kyung} and Jung, {Chang Hee} and Park, {Cheol Young} and Cho, {Jae Hyoung} and Lee, {Woo Je} and byungwan lee and Kim, {Jae Hyeon}",
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Lee, EY, Lee, YH, Jin, SM, Yang, HK, Jung, CH, Park, CY, Cho, JH, Lee, WJ, lee, B & Kim, JH 2017, 'Differential association of body mass index on glycemic control in type 1 diabetes', Diabetes/Metabolism Research and Reviews, vol. 33, no. 1, e2815. https://doi.org/10.1002/dmrr.2815

Differential association of body mass index on glycemic control in type 1 diabetes. / Lee, Eun Young; Lee, Yong Ho; Jin, Sang Man; Yang, Hae Kyung; Jung, Chang Hee; Park, Cheol Young; Cho, Jae Hyoung; Lee, Woo Je; lee, byungwan; Kim, Jae Hyeon.

In: Diabetes/Metabolism Research and Reviews, Vol. 33, No. 1, e2815, 01.01.2017.

Research output: Contribution to journalArticle

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T1 - Differential association of body mass index on glycemic control in type 1 diabetes

AU - Lee, Eun Young

AU - Lee, Yong Ho

AU - Jin, Sang Man

AU - Yang, Hae Kyung

AU - Jung, Chang Hee

AU - Park, Cheol Young

AU - Cho, Jae Hyoung

AU - Lee, Woo Je

AU - lee, byungwan

AU - Kim, Jae Hyeon

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: In contrast to type 2 diabetes, the association of body mass index (BMI) with glycemic control in type 1 diabetes (T1D) remains unclear. We investigated the relationship between BMI and average HbA1c levels in subjects with T1D. Method: In this multi-centre observational study, we analysed 719 subjects with T1D aged ≥18 years. Average HbA1c levels over 18 months and other clinical and laboratory parameters were evaluated. Results: The mean age and duration of diabetes at baseline were 41.5 ± 13.9 and 11.3 ± 8.7 years, respectively. A U-shaped correlation between BMI and 18-month average HbA1c levels was documented by a spline curve. Based on this finding, subjects were divided into three groups according to BMI (group I, <21; group II, 21–23; and group III, ≥23 kg/m2). In group I, the BMI negatively correlated with average HbA1c (r = −0.172, p = 0.011), while a positive relationship was observed (r = 0.162, p = 0.012) in group III. Average HbA1c levels were lower and the proportion of individuals with well-controlled glycemia (HbA1c <7%) were increased in the higher BMI tertile group among subjects with group I as well as in the lower BMI tertile group among subjects with group III BMI. After adjustment with additional covariates in the multiple regression model, these associations between BMI and HbA1c levels according to the different BMI ranges remained significant. Conclusions: In Korean subjects with T1D, an inverse relationship of BMI with HbA1c levels was observed in the low BMI group, while a positive correlation was shown in the high BMI group.

AB - Background: In contrast to type 2 diabetes, the association of body mass index (BMI) with glycemic control in type 1 diabetes (T1D) remains unclear. We investigated the relationship between BMI and average HbA1c levels in subjects with T1D. Method: In this multi-centre observational study, we analysed 719 subjects with T1D aged ≥18 years. Average HbA1c levels over 18 months and other clinical and laboratory parameters were evaluated. Results: The mean age and duration of diabetes at baseline were 41.5 ± 13.9 and 11.3 ± 8.7 years, respectively. A U-shaped correlation between BMI and 18-month average HbA1c levels was documented by a spline curve. Based on this finding, subjects were divided into three groups according to BMI (group I, <21; group II, 21–23; and group III, ≥23 kg/m2). In group I, the BMI negatively correlated with average HbA1c (r = −0.172, p = 0.011), while a positive relationship was observed (r = 0.162, p = 0.012) in group III. Average HbA1c levels were lower and the proportion of individuals with well-controlled glycemia (HbA1c <7%) were increased in the higher BMI tertile group among subjects with group I as well as in the lower BMI tertile group among subjects with group III BMI. After adjustment with additional covariates in the multiple regression model, these associations between BMI and HbA1c levels according to the different BMI ranges remained significant. Conclusions: In Korean subjects with T1D, an inverse relationship of BMI with HbA1c levels was observed in the low BMI group, while a positive correlation was shown in the high BMI group.

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