Differential biological responses of green tea polyphenol in normal cells vs. cancer cells

Han Ki Park, Dong Wook Han, Young Hwan Park, Jong Chul Park

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Green tea has shown remarkable anti-inflammatory and cancer chemopreventive effects in many animal tumor bioassays, cell culture systems and epidemiological studies. Many of these biological effects of green tea are mediated by epigallocatechin 3-gallate, the major polyphenol present therein. In this study, the differential biological responses of green tea polyphenols (GTP) were examined in normal rat osteoblasts (NRO) vs. human osteosarcoma (MG-63 and Saos-2) cells. The GTP treatment with micromolar concentrations (0.1, 1, 10 and 100 μM for 24 h) resulted in dose-dependent inhibitions of cell growth and alkaline phosphatase activity, morphological alterations, G0/G1-phase arrest of the cell cycle and induction of apoptosis in both osteosarcoma cells, but not in the NRO. These results suggest that the GTP treatment may be contributed to the differential regulation of cell cycle in normal cells and cancer cells, which can be exploited to craft strategies for the physiological preservation of cells or tissues by GTP.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalCurrent Applied Physics
Issue number5
Publication statusPublished - 2005 Jul

Bibliographical note

Funding Information:
This study was supported by the Ministry of Health and Welfare of the Republic of Korea (Grant No. 02-PJ3-PG3-31402-0018).

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)


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