Differential biological responses of green tea polyphenol in normal cells vs. cancer cells

Han Ki Park, Dong Wook Han, Young Hwan Park, Jongchul Park

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Green tea has shown remarkable anti-inflammatory and cancer chemopreventive effects in many animal tumor bioassays, cell culture systems and epidemiological studies. Many of these biological effects of green tea are mediated by epigallocatechin 3-gallate, the major polyphenol present therein. In this study, the differential biological responses of green tea polyphenols (GTP) were examined in normal rat osteoblasts (NRO) vs. human osteosarcoma (MG-63 and Saos-2) cells. The GTP treatment with micromolar concentrations (0.1, 1, 10 and 100 μM for 24 h) resulted in dose-dependent inhibitions of cell growth and alkaline phosphatase activity, morphological alterations, G0/G1-phase arrest of the cell cycle and induction of apoptosis in both osteosarcoma cells, but not in the NRO. These results suggest that the GTP treatment may be contributed to the differential regulation of cell cycle in normal cells and cancer cells, which can be exploited to craft strategies for the physiological preservation of cells or tissues by GTP.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalCurrent Applied Physics
Volume5
Issue number5
DOIs
Publication statusPublished - 2005 Jul 1

Fingerprint

Polyphenols
cancer
Cells
osteoblasts
cells
Osteoblasts
rats
Rats
gallates
bioassay
cycles
phosphatases
biological effects
Enzyme inhibition
apoptosis
Bioassay
Phosphatases
Cell growth
Cell death
animals

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science (miscellaneous)

Cite this

Park, Han Ki ; Han, Dong Wook ; Park, Young Hwan ; Park, Jongchul. / Differential biological responses of green tea polyphenol in normal cells vs. cancer cells. In: Current Applied Physics. 2005 ; Vol. 5, No. 5. pp. 449-452.
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Differential biological responses of green tea polyphenol in normal cells vs. cancer cells. / Park, Han Ki; Han, Dong Wook; Park, Young Hwan; Park, Jongchul.

In: Current Applied Physics, Vol. 5, No. 5, 01.07.2005, p. 449-452.

Research output: Contribution to journalArticle

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