DIFFERENTIAL DIAGNOSIS for VITREORETINAL LYMPHOMA with VITREORETINAL FINDINGS, IMMUNOGLOBULIN CLONALITY TESTS, and INTERLEUKIN LEVELS

Junwon Lee, Seung W.O.O. Kim, Hyesun Kim, Christopher Seungkyu Lee, Min Kim, Sung Chul Lee

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Purpose:To analyze vitreoretinal findings, immunoglobulin clonality tests, and interleukin (IL) levels for diagnosing vitreoretinal lymphoma (VRL).Methods:Forty-three patients who underwent diagnostic vitrectomy for suspected VRL were retrospectively reviewed. Of those patients finally diagnosed with VRL and nonlymphoma, ophthalmic evaluation and cytology results, IL-6 and IL-10 levels, and immunoglobulin heavy chain and immunoglobulin kappa light chain clonality assays were compared.Results:Sub-retinal pigment epithelium infiltration and veil-pattern vitreous opacity were specific vitreoretinal findings in patients with VRL. The area under the receiver operating characteristic curve of the IL-10-to-IL-6 ratio and of IL-10 levels was 0.972 and 0.931, respectively. A combined immunoglobulin heavy chain and immunoglobulin kappa light chain assay showed increased sensitivity, whereas the determined specificity of immunoglobulin kappa light chain, at 94.12%, was much higher than the 78.95% of immunoglobulin heavy chain. Patients with VRL with atypically elevated IL-6 levels showed extensive and severe sub-retinal pigment epithelium infiltration.Conclusion:Newly screened immunoglobulin kappa light chain clonality assays may be useful to distinguish VRL from uveitis with high specificity. When sub-retinal pigment epithelium or retinal infiltration is severe and extensive, the IL-10-to-IL-6 ratio may not be typical and should be carefully interpreted.

Original languageEnglish
Pages (from-to)1165-1176
Number of pages12
JournalRetina
Volume39
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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