Differential effect of side branch intervention on long-term clinical outcomes according to side branch stenosis after main vessel stenting: Results from the COBIS (Coronary Bifurcation Stenting) Registry II

Woo Jin Jang, Yong Hwan Park, Joo Yong Hahn, Young Bin Song, Seung Hyuk Choi, Woo Jung Chun, Ju Hyeon Oh, Bon Kwon Koo, Seung Woon Rha, Yangsoo Jang, Seung Jea Tahk, Hyo Soo Kim, Hyeon Cheol Gwon

Research output: Contribution to journalArticle

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Abstract

Background Indication of side branch (SB) intervention after main vessel (MV) stenting is not established for coronary bifurcation lesions. Methods We evaluated 2017 patients who were treated with 1-stent technique or MV stenting as a first strategy. Patients undergoing SB intervention after MV stenting (SB intervention group, n = 929) were compared to those treated with MV stenting only (no-SB intervention group, n = 1088). Results During a median follow-up of 37 months, cardiac death or myocardial infarction (MI) tended to occur less frequently in the SB intervention group than in the no-SB intervention group (1.8% versus 2.9%; adjusted hazard ratio [HR] 0.53; 95% confidence interval [CI] 0.25–1.11; P = 0.09). There was a significant interaction between SB intervention and SB stenosis after MV stenting (P for interaction < 0.01). Among 1077 patients with diameter stenosis of SB ≥ 50% after MV stenting, SB intervention was associated with a lower risk of cardiac death or MI (1.2% versus 4.2%; adjusted HR 0.22; 95% CI 0.09–0.52; P < 0.01). However, among 940 patients with diameter stenosis of SB < 50%, there was no significant difference in cardiac death or MI between the SB intervention group and the no-SB intervention group (3.5% versus 2.2%; adjusted HR 1.36; 95% CI 0.58–3.20; P = 0.48). Conclusions The effect of SB intervention differed according to SB stenosis after MV stenting. SB intervention may reduce cardiac death or MI in bifurcation lesions with diameter stenosis of SB ≥ 50% after MV stenting.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalInternational Journal of Cardiology
Volume221
DOIs
Publication statusPublished - 2016 Oct 15

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Registries
Pathologic Constriction
Myocardial Infarction
Confidence Intervals
Stents

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Jang, Woo Jin ; Park, Yong Hwan ; Hahn, Joo Yong ; Song, Young Bin ; Choi, Seung Hyuk ; Chun, Woo Jung ; Hyeon Oh, Ju ; Koo, Bon Kwon ; Rha, Seung Woon ; Jang, Yangsoo ; Tahk, Seung Jea ; Kim, Hyo Soo ; Gwon, Hyeon Cheol. / Differential effect of side branch intervention on long-term clinical outcomes according to side branch stenosis after main vessel stenting : Results from the COBIS (Coronary Bifurcation Stenting) Registry II. In: International Journal of Cardiology. 2016 ; Vol. 221. pp. 471-477.
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title = "Differential effect of side branch intervention on long-term clinical outcomes according to side branch stenosis after main vessel stenting: Results from the COBIS (Coronary Bifurcation Stenting) Registry II",
abstract = "Background Indication of side branch (SB) intervention after main vessel (MV) stenting is not established for coronary bifurcation lesions. Methods We evaluated 2017 patients who were treated with 1-stent technique or MV stenting as a first strategy. Patients undergoing SB intervention after MV stenting (SB intervention group, n = 929) were compared to those treated with MV stenting only (no-SB intervention group, n = 1088). Results During a median follow-up of 37 months, cardiac death or myocardial infarction (MI) tended to occur less frequently in the SB intervention group than in the no-SB intervention group (1.8{\%} versus 2.9{\%}; adjusted hazard ratio [HR] 0.53; 95{\%} confidence interval [CI] 0.25–1.11; P = 0.09). There was a significant interaction between SB intervention and SB stenosis after MV stenting (P for interaction < 0.01). Among 1077 patients with diameter stenosis of SB ≥ 50{\%} after MV stenting, SB intervention was associated with a lower risk of cardiac death or MI (1.2{\%} versus 4.2{\%}; adjusted HR 0.22; 95{\%} CI 0.09–0.52; P < 0.01). However, among 940 patients with diameter stenosis of SB < 50{\%}, there was no significant difference in cardiac death or MI between the SB intervention group and the no-SB intervention group (3.5{\%} versus 2.2{\%}; adjusted HR 1.36; 95{\%} CI 0.58–3.20; P = 0.48). Conclusions The effect of SB intervention differed according to SB stenosis after MV stenting. SB intervention may reduce cardiac death or MI in bifurcation lesions with diameter stenosis of SB ≥ 50{\%} after MV stenting.",
author = "Jang, {Woo Jin} and Park, {Yong Hwan} and Hahn, {Joo Yong} and Song, {Young Bin} and Choi, {Seung Hyuk} and Chun, {Woo Jung} and {Hyeon Oh}, Ju and Koo, {Bon Kwon} and Rha, {Seung Woon} and Yangsoo Jang and Tahk, {Seung Jea} and Kim, {Hyo Soo} and Gwon, {Hyeon Cheol}",
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Differential effect of side branch intervention on long-term clinical outcomes according to side branch stenosis after main vessel stenting : Results from the COBIS (Coronary Bifurcation Stenting) Registry II. / Jang, Woo Jin; Park, Yong Hwan; Hahn, Joo Yong; Song, Young Bin; Choi, Seung Hyuk; Chun, Woo Jung; Hyeon Oh, Ju; Koo, Bon Kwon; Rha, Seung Woon; Jang, Yangsoo; Tahk, Seung Jea; Kim, Hyo Soo; Gwon, Hyeon Cheol.

In: International Journal of Cardiology, Vol. 221, 15.10.2016, p. 471-477.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential effect of side branch intervention on long-term clinical outcomes according to side branch stenosis after main vessel stenting

T2 - Results from the COBIS (Coronary Bifurcation Stenting) Registry II

AU - Jang, Woo Jin

AU - Park, Yong Hwan

AU - Hahn, Joo Yong

AU - Song, Young Bin

AU - Choi, Seung Hyuk

AU - Chun, Woo Jung

AU - Hyeon Oh, Ju

AU - Koo, Bon Kwon

AU - Rha, Seung Woon

AU - Jang, Yangsoo

AU - Tahk, Seung Jea

AU - Kim, Hyo Soo

AU - Gwon, Hyeon Cheol

PY - 2016/10/15

Y1 - 2016/10/15

N2 - Background Indication of side branch (SB) intervention after main vessel (MV) stenting is not established for coronary bifurcation lesions. Methods We evaluated 2017 patients who were treated with 1-stent technique or MV stenting as a first strategy. Patients undergoing SB intervention after MV stenting (SB intervention group, n = 929) were compared to those treated with MV stenting only (no-SB intervention group, n = 1088). Results During a median follow-up of 37 months, cardiac death or myocardial infarction (MI) tended to occur less frequently in the SB intervention group than in the no-SB intervention group (1.8% versus 2.9%; adjusted hazard ratio [HR] 0.53; 95% confidence interval [CI] 0.25–1.11; P = 0.09). There was a significant interaction between SB intervention and SB stenosis after MV stenting (P for interaction < 0.01). Among 1077 patients with diameter stenosis of SB ≥ 50% after MV stenting, SB intervention was associated with a lower risk of cardiac death or MI (1.2% versus 4.2%; adjusted HR 0.22; 95% CI 0.09–0.52; P < 0.01). However, among 940 patients with diameter stenosis of SB < 50%, there was no significant difference in cardiac death or MI between the SB intervention group and the no-SB intervention group (3.5% versus 2.2%; adjusted HR 1.36; 95% CI 0.58–3.20; P = 0.48). Conclusions The effect of SB intervention differed according to SB stenosis after MV stenting. SB intervention may reduce cardiac death or MI in bifurcation lesions with diameter stenosis of SB ≥ 50% after MV stenting.

AB - Background Indication of side branch (SB) intervention after main vessel (MV) stenting is not established for coronary bifurcation lesions. Methods We evaluated 2017 patients who were treated with 1-stent technique or MV stenting as a first strategy. Patients undergoing SB intervention after MV stenting (SB intervention group, n = 929) were compared to those treated with MV stenting only (no-SB intervention group, n = 1088). Results During a median follow-up of 37 months, cardiac death or myocardial infarction (MI) tended to occur less frequently in the SB intervention group than in the no-SB intervention group (1.8% versus 2.9%; adjusted hazard ratio [HR] 0.53; 95% confidence interval [CI] 0.25–1.11; P = 0.09). There was a significant interaction between SB intervention and SB stenosis after MV stenting (P for interaction < 0.01). Among 1077 patients with diameter stenosis of SB ≥ 50% after MV stenting, SB intervention was associated with a lower risk of cardiac death or MI (1.2% versus 4.2%; adjusted HR 0.22; 95% CI 0.09–0.52; P < 0.01). However, among 940 patients with diameter stenosis of SB < 50%, there was no significant difference in cardiac death or MI between the SB intervention group and the no-SB intervention group (3.5% versus 2.2%; adjusted HR 1.36; 95% CI 0.58–3.20; P = 0.48). Conclusions The effect of SB intervention differed according to SB stenosis after MV stenting. SB intervention may reduce cardiac death or MI in bifurcation lesions with diameter stenosis of SB ≥ 50% after MV stenting.

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