Differential effects of arterial stiffness and fluid overload on blood pressure according to renal function in patients at risk for cardiovascular disease

Seohyun Park, Chan Joo Lee, Misol Lee, Min Uk Cha, Seong Yeong An, Ki Heon Nam, Jong Hyun Jhee, Hae Ryong Yun, Hyoungnae Kim, Youn Kyung Kee, Jung Tak Park, Hyeon Chang Kim, Tae Hyun Yoo, Shin Wook Kang, Sungha Park, Seung Hyeok Han

Research output: Contribution to journalArticle

Abstract

The pathogenesis of hypertension is multifactorial in patients with chronic kidney disease (CKD). We explored the relative contribution of arterial stiffness and fluid overload to blood pressure (BP) in these patients. We evaluated 1531 patients from a prospective observational cohort study of high-risk patients with cardiovascular disease. BP, arterial stiffness, and volume status expressed as the extracellular water/total body water ratio (ECW/TBW) were measured by 24-h BP monitoring, pulse-wave velocity (PWV), and bioelectrical impedance analysis, respectively. Multiple linear regression analysis showed that both PWV and ECW/TBW of the patients with CKD were significantly associated with 24-h systolic BP (SBP). The areas under the receiver-operating characteristic curve (AUCs) for predicting 24-h SBP ≥130 mm Hg significantly increased after PWV was added to conventional factors regardless of CKD status. However, the AUCs did not increase in the ECW/TBW-based models. When a cut-off 24-h SBP level of 140 mm Hg was used, the predictability of ECW/TBW for elevated BP significantly improved in patients with CKD (0.718 vs. 0.683, P = 0.034) but not in those without. Notably, a significant impact of arterial stiffness on high BP was consistently observed regardless of CKD status. This association was further confirmed by the net reclassification and integrated discriminant improvements, root mean squared error with adjusted R 2 , and interaction effects. As kidney function declines, fluid overload is significantly associated with high BP. The impact of fluid overload on BP is only observed in more severe hypertension in patients with CKD.

Original languageEnglish
Pages (from-to)341-353
Number of pages13
JournalHypertension Research
Volume42
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

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Vascular Stiffness
Chronic Renal Insufficiency
Cardiovascular Diseases
Blood Pressure
Body Water
Kidney
Pulse Wave Analysis
Hypertension
Water
Area Under Curve
Electric Impedance
ROC Curve
Observational Studies
Linear Models
Cohort Studies
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Park, Seohyun ; Lee, Chan Joo ; Lee, Misol ; Cha, Min Uk ; An, Seong Yeong ; Nam, Ki Heon ; Jhee, Jong Hyun ; Yun, Hae Ryong ; Kim, Hyoungnae ; Kee, Youn Kyung ; Park, Jung Tak ; Kim, Hyeon Chang ; Yoo, Tae Hyun ; Kang, Shin Wook ; Park, Sungha ; Han, Seung Hyeok. / Differential effects of arterial stiffness and fluid overload on blood pressure according to renal function in patients at risk for cardiovascular disease. In: Hypertension Research. 2019 ; Vol. 42, No. 3. pp. 341-353.
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Differential effects of arterial stiffness and fluid overload on blood pressure according to renal function in patients at risk for cardiovascular disease. / Park, Seohyun; Lee, Chan Joo; Lee, Misol; Cha, Min Uk; An, Seong Yeong; Nam, Ki Heon; Jhee, Jong Hyun; Yun, Hae Ryong; Kim, Hyoungnae; Kee, Youn Kyung; Park, Jung Tak; Kim, Hyeon Chang; Yoo, Tae Hyun; Kang, Shin Wook; Park, Sungha; Han, Seung Hyeok.

In: Hypertension Research, Vol. 42, No. 3, 01.03.2019, p. 341-353.

Research output: Contribution to journalArticle

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AU - Park, Seohyun

AU - Lee, Chan Joo

AU - Lee, Misol

AU - Cha, Min Uk

AU - An, Seong Yeong

AU - Nam, Ki Heon

AU - Jhee, Jong Hyun

AU - Yun, Hae Ryong

AU - Kim, Hyoungnae

AU - Kee, Youn Kyung

AU - Park, Jung Tak

AU - Kim, Hyeon Chang

AU - Yoo, Tae Hyun

AU - Kang, Shin Wook

AU - Park, Sungha

AU - Han, Seung Hyeok

PY - 2019/3/1

Y1 - 2019/3/1

N2 - The pathogenesis of hypertension is multifactorial in patients with chronic kidney disease (CKD). We explored the relative contribution of arterial stiffness and fluid overload to blood pressure (BP) in these patients. We evaluated 1531 patients from a prospective observational cohort study of high-risk patients with cardiovascular disease. BP, arterial stiffness, and volume status expressed as the extracellular water/total body water ratio (ECW/TBW) were measured by 24-h BP monitoring, pulse-wave velocity (PWV), and bioelectrical impedance analysis, respectively. Multiple linear regression analysis showed that both PWV and ECW/TBW of the patients with CKD were significantly associated with 24-h systolic BP (SBP). The areas under the receiver-operating characteristic curve (AUCs) for predicting 24-h SBP ≥130 mm Hg significantly increased after PWV was added to conventional factors regardless of CKD status. However, the AUCs did not increase in the ECW/TBW-based models. When a cut-off 24-h SBP level of 140 mm Hg was used, the predictability of ECW/TBW for elevated BP significantly improved in patients with CKD (0.718 vs. 0.683, P = 0.034) but not in those without. Notably, a significant impact of arterial stiffness on high BP was consistently observed regardless of CKD status. This association was further confirmed by the net reclassification and integrated discriminant improvements, root mean squared error with adjusted R 2 , and interaction effects. As kidney function declines, fluid overload is significantly associated with high BP. The impact of fluid overload on BP is only observed in more severe hypertension in patients with CKD.

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