Differential expressions of IL-3 and FcRI in the peripheral blood mononuclear cells and lesional skin of patients with extrinsic atopic dermatitis and intrinsic atopic dermatitis

Shan Jin, Seongmin Noh, Byung Gi Bae, Chang Ook Ook Park, Kwang Hoon Lee

Research output: Contribution to journalArticle

Abstract

Background: A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed 'intrinsic' AD (IAD) as compared to its counterpart 'extrinsic' AD (EAD). However, the difference of cytokine expression between IAD and EAD has not been fully understood. Objective: To compare the expression of various inflammatory cytokines in the peripheral blood mononuclear cells (PBMCs) and lesional skin of patients with IAD and EAD, which are known to be associated with AD pathophysiology. Methods: We assessed the protein levels of cytokines in the PBMCs and lesional skin. We evaluated the levels of IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, FcRI and FcRII from the PBMCs and lesional skin of patients with IAD and EAD. Results: The patients with EAD had elevated levels of the IL-3 expression in their PBMCs and elevated levels of FcRI in their lesional skin compared to that of the patients with IAD. The expression of other cytokines did not differ in the PBMCs and lesional skin from the two subgroups. Conclusion: This study suggests that IL-3 could be associated with the pathophysiology of EAD as compared to that of IAD, along with FcRI which was previously shown to be highly expressed in EAD patients.

Original languageEnglish
Pages (from-to)491-498
Number of pages8
JournalKorean Journal of Dermatology
Volume49
Issue number6
Publication statusPublished - 2011 Jun 1

Fingerprint

Interleukin-3
Atopic Dermatitis
Blood Cells
Skin
Cytokines
Interleukin-13
Interleukin-5
Interleukin-4
Interleukin-10
Allergens
Immunoglobulin E
Immunoglobulins
Interleukin-6
Proteins

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

@article{62c3556a7c2c45c1832b594ef5aa2166,
title = "Differential expressions of IL-3 and FcRI in the peripheral blood mononuclear cells and lesional skin of patients with extrinsic atopic dermatitis and intrinsic atopic dermatitis",
abstract = "Background: A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed 'intrinsic' AD (IAD) as compared to its counterpart 'extrinsic' AD (EAD). However, the difference of cytokine expression between IAD and EAD has not been fully understood. Objective: To compare the expression of various inflammatory cytokines in the peripheral blood mononuclear cells (PBMCs) and lesional skin of patients with IAD and EAD, which are known to be associated with AD pathophysiology. Methods: We assessed the protein levels of cytokines in the PBMCs and lesional skin. We evaluated the levels of IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, FcRI and FcRII from the PBMCs and lesional skin of patients with IAD and EAD. Results: The patients with EAD had elevated levels of the IL-3 expression in their PBMCs and elevated levels of FcRI in their lesional skin compared to that of the patients with IAD. The expression of other cytokines did not differ in the PBMCs and lesional skin from the two subgroups. Conclusion: This study suggests that IL-3 could be associated with the pathophysiology of EAD as compared to that of IAD, along with FcRI which was previously shown to be highly expressed in EAD patients.",
author = "Shan Jin and Seongmin Noh and Bae, {Byung Gi} and {Ook Park}, {Chang Ook} and Lee, {Kwang Hoon}",
year = "2011",
month = "6",
day = "1",
language = "English",
volume = "49",
pages = "491--498",
journal = "Korean Journal of Dermatology",
issn = "0494-4739",
publisher = "Korean Dermatological Association",
number = "6",

}

Differential expressions of IL-3 and FcRI in the peripheral blood mononuclear cells and lesional skin of patients with extrinsic atopic dermatitis and intrinsic atopic dermatitis. / Jin, Shan; Noh, Seongmin; Bae, Byung Gi; Ook Park, Chang Ook; Lee, Kwang Hoon.

In: Korean Journal of Dermatology, Vol. 49, No. 6, 01.06.2011, p. 491-498.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential expressions of IL-3 and FcRI in the peripheral blood mononuclear cells and lesional skin of patients with extrinsic atopic dermatitis and intrinsic atopic dermatitis

AU - Jin, Shan

AU - Noh, Seongmin

AU - Bae, Byung Gi

AU - Ook Park, Chang Ook

AU - Lee, Kwang Hoon

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Background: A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed 'intrinsic' AD (IAD) as compared to its counterpart 'extrinsic' AD (EAD). However, the difference of cytokine expression between IAD and EAD has not been fully understood. Objective: To compare the expression of various inflammatory cytokines in the peripheral blood mononuclear cells (PBMCs) and lesional skin of patients with IAD and EAD, which are known to be associated with AD pathophysiology. Methods: We assessed the protein levels of cytokines in the PBMCs and lesional skin. We evaluated the levels of IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, FcRI and FcRII from the PBMCs and lesional skin of patients with IAD and EAD. Results: The patients with EAD had elevated levels of the IL-3 expression in their PBMCs and elevated levels of FcRI in their lesional skin compared to that of the patients with IAD. The expression of other cytokines did not differ in the PBMCs and lesional skin from the two subgroups. Conclusion: This study suggests that IL-3 could be associated with the pathophysiology of EAD as compared to that of IAD, along with FcRI which was previously shown to be highly expressed in EAD patients.

AB - Background: A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed 'intrinsic' AD (IAD) as compared to its counterpart 'extrinsic' AD (EAD). However, the difference of cytokine expression between IAD and EAD has not been fully understood. Objective: To compare the expression of various inflammatory cytokines in the peripheral blood mononuclear cells (PBMCs) and lesional skin of patients with IAD and EAD, which are known to be associated with AD pathophysiology. Methods: We assessed the protein levels of cytokines in the PBMCs and lesional skin. We evaluated the levels of IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, FcRI and FcRII from the PBMCs and lesional skin of patients with IAD and EAD. Results: The patients with EAD had elevated levels of the IL-3 expression in their PBMCs and elevated levels of FcRI in their lesional skin compared to that of the patients with IAD. The expression of other cytokines did not differ in the PBMCs and lesional skin from the two subgroups. Conclusion: This study suggests that IL-3 could be associated with the pathophysiology of EAD as compared to that of IAD, along with FcRI which was previously shown to be highly expressed in EAD patients.

UR - http://www.scopus.com/inward/record.url?scp=79960956695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960956695&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:79960956695

VL - 49

SP - 491

EP - 498

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

IS - 6

ER -