Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

Ki Bum Won, Hyuk Jae Chang, Hyeon Chang Kim, Kyewon Jeon, Hancheol Lee, Sanghoon Shin, In Jeong Cho, Sung Ha Park, Sang Hak Lee, Yangsoo Jang

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Abstract

Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study.Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.

Original languageEnglish
Article number41
JournalCardiovascular Diabetology
Volume12
Issue number1
DOIs
Publication statusPublished - 2013 Mar 4

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Atherosclerosis
Pulse Wave Analysis
Ankle
Arm
Cohort Studies
Cardiovascular Diseases
Biomarkers
Blood Pressure
Health

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

@article{0c0ebf5dd1834bdbb50e57684dd904e2,
title = "Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes",
abstract = "Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33{\%} men) who participated in baseline health examinations for a community-based cohort study.Results: The participants included 2,149 non-diabetics (84{\%}) and 411 diabetics (16{\%}); 667 non-diabetics (31{\%}) and 285 diabetics (69{\%}) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.",
author = "Won, {Ki Bum} and Chang, {Hyuk Jae} and Kim, {Hyeon Chang} and Kyewon Jeon and Hancheol Lee and Sanghoon Shin and Cho, {In Jeong} and Park, {Sung Ha} and Lee, {Sang Hak} and Yangsoo Jang",
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Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes. / Won, Ki Bum; Chang, Hyuk Jae; Kim, Hyeon Chang; Jeon, Kyewon; Lee, Hancheol; Shin, Sanghoon; Cho, In Jeong; Park, Sung Ha; Lee, Sang Hak; Jang, Yangsoo.

In: Cardiovascular Diabetology, Vol. 12, No. 1, 41, 04.03.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

AU - Won, Ki Bum

AU - Chang, Hyuk Jae

AU - Kim, Hyeon Chang

AU - Jeon, Kyewon

AU - Lee, Hancheol

AU - Shin, Sanghoon

AU - Cho, In Jeong

AU - Park, Sung Ha

AU - Lee, Sang Hak

AU - Jang, Yangsoo

PY - 2013/3/4

Y1 - 2013/3/4

N2 - Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study.Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.

AB - Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study.Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.

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U2 - 10.1186/1475-2840-12-41

DO - 10.1186/1475-2840-12-41

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