Differential self-assembly behaviors of cyclic and linear peptides.

Sung ju Choi, Woo jin Jeong, Seong Kyun Kang, Myongsoo Lee, Eunhye Kim, Du Yeol Ryu, Yong beom Lim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Here we ask the fundamental questions about the effect of peptide topology on self-assembly. The study revealed that the self-assembling behaviors of cyclic and linear peptides are significantly different in several respects, in addition to sharing several similarities. Their clear differences included the morphological dissimilarities of the self-assembled nanostructures and their thermal stability. The similarities include their analogous critical aggregation concentration values and cytotoxicity profiles, which are in fact closely related. We believe that understanding topology-dependent self-assembly behavior of peptides is important for developing tailor-made self-assembled peptide nanostructures.

Original languageEnglish
Pages (from-to)1991-1995
Number of pages5
JournalBiomacromolecules
Volume13
Issue number7
DOIs
Publication statusPublished - 2012 Jul 9

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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