Differential self-assembly behaviors of cyclic and linear peptides.

Sung ju Choi, Woo jin Jeong, Seong Kyun Kang, Myongsoo Lee, Eunhye Kim, Du Yeol Ryu, Yong-beom Lim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Here we ask the fundamental questions about the effect of peptide topology on self-assembly. The study revealed that the self-assembling behaviors of cyclic and linear peptides are significantly different in several respects, in addition to sharing several similarities. Their clear differences included the morphological dissimilarities of the self-assembled nanostructures and their thermal stability. The similarities include their analogous critical aggregation concentration values and cytotoxicity profiles, which are in fact closely related. We believe that understanding topology-dependent self-assembly behavior of peptides is important for developing tailor-made self-assembled peptide nanostructures.

Original languageEnglish
Pages (from-to)1991-1995
Number of pages5
JournalBiomacromolecules
Volume13
Issue number7
DOIs
Publication statusPublished - 2012 Jul 9

Fingerprint

Self assembly
Peptides
Nanostructures
Topology
Cytotoxicity
Thermodynamic stability
Agglomeration

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Choi, Sung ju ; Jeong, Woo jin ; Kang, Seong Kyun ; Lee, Myongsoo ; Kim, Eunhye ; Ryu, Du Yeol ; Lim, Yong-beom. / Differential self-assembly behaviors of cyclic and linear peptides. In: Biomacromolecules. 2012 ; Vol. 13, No. 7. pp. 1991-1995.
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Differential self-assembly behaviors of cyclic and linear peptides. / Choi, Sung ju; Jeong, Woo jin; Kang, Seong Kyun; Lee, Myongsoo; Kim, Eunhye; Ryu, Du Yeol; Lim, Yong-beom.

In: Biomacromolecules, Vol. 13, No. 7, 09.07.2012, p. 1991-1995.

Research output: Contribution to journalArticle

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