Differentiation between focal malignant marrow-replacing lesions and benign red marrow deposition of the spine with t2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence

Yong Pyo Kim, Stephan Kannengiesser, Mun Young Paek, Sungjun Kim, Tae Sub Chung, Yeon Hwa Yoo, Choon Sik Yoon, Ho Taek Song, Young Han Lee, Jinsuck Suh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To assess the feasibility of T2*-corrected fat-signal fraction (FF) map by using the three-echo volume interpolated breath-hold gradient echo (VIBE) Dixon sequence to differentiate between malignant marrow-replacing lesions and benign red marrow deposition of vertebrae.

Materials and Methods: We assessed 32 lesions from 32 patients who underwent magnetic resonance imaging after being referred for assessment of a known or possible vertebral marrow abnormality. The lesions were divided into 21 malignant marrow-replacing lesions and 11 benign red marrow depositions. Three sequences for the parameter measurements were obtained by using a 1.5-T MR imaging scanner as follows: three-echo VIBE Dixon sequence for FF; conventional T1-weighted imaging for the lesion-disc ratio (LDR); pre-and post-gadolinium enhanced fat-suppressed T1-weighted images for the contrast-enhancement ratio (CER). A region of interest was drawn for each lesion for parameter measurements. The areas under the curve (AUC) of the parameters and their sensitivities and specificities at the most ideal cutoff values from receiver operating characteristic curve analysis were obtained. AUC, sensitivity, and specificity were respectively compared between FF and CER.

Results: The AUCs of FF, LDR, and CER were 0.96, 0.80, and 0.72, respectively. In the comparison of diagnostic performance between the FF and CER, the FF showed a significantly larger AUC as compared to the CER (p = 0.030), although the difference of sensitivity (p = 0.157) and specificity (p = 0.157) were not significant.

Conclusion: Fat-signal fraction measurement using T2*-corrected three-echo VIBE Dixon sequence is feasible and has a more accurate diagnostic performance, than the CER, in distinguishing benign red marrow deposition from malignant bone marrow-replacing lesions.

Original languageEnglish
Pages (from-to)781-791
Number of pages11
JournalKorean Journal of Radiology
Volume15
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Spine
Bone Marrow
Fats
Area Under Curve
Image Enhancement
Sensitivity and Specificity
Gadolinium
Protein Sorting Signals
ROC Curve
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Yong Pyo ; Kannengiesser, Stephan ; Paek, Mun Young ; Kim, Sungjun ; Chung, Tae Sub ; Yoo, Yeon Hwa ; Yoon, Choon Sik ; Song, Ho Taek ; Lee, Young Han ; Suh, Jinsuck. / Differentiation between focal malignant marrow-replacing lesions and benign red marrow deposition of the spine with t2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence. In: Korean Journal of Radiology. 2014 ; Vol. 15, No. 6. pp. 781-791.
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abstract = "Objective: To assess the feasibility of T2*-corrected fat-signal fraction (FF) map by using the three-echo volume interpolated breath-hold gradient echo (VIBE) Dixon sequence to differentiate between malignant marrow-replacing lesions and benign red marrow deposition of vertebrae.Materials and Methods: We assessed 32 lesions from 32 patients who underwent magnetic resonance imaging after being referred for assessment of a known or possible vertebral marrow abnormality. The lesions were divided into 21 malignant marrow-replacing lesions and 11 benign red marrow depositions. Three sequences for the parameter measurements were obtained by using a 1.5-T MR imaging scanner as follows: three-echo VIBE Dixon sequence for FF; conventional T1-weighted imaging for the lesion-disc ratio (LDR); pre-and post-gadolinium enhanced fat-suppressed T1-weighted images for the contrast-enhancement ratio (CER). A region of interest was drawn for each lesion for parameter measurements. The areas under the curve (AUC) of the parameters and their sensitivities and specificities at the most ideal cutoff values from receiver operating characteristic curve analysis were obtained. AUC, sensitivity, and specificity were respectively compared between FF and CER.Results: The AUCs of FF, LDR, and CER were 0.96, 0.80, and 0.72, respectively. In the comparison of diagnostic performance between the FF and CER, the FF showed a significantly larger AUC as compared to the CER (p = 0.030), although the difference of sensitivity (p = 0.157) and specificity (p = 0.157) were not significant.Conclusion: Fat-signal fraction measurement using T2*-corrected three-echo VIBE Dixon sequence is feasible and has a more accurate diagnostic performance, than the CER, in distinguishing benign red marrow deposition from malignant bone marrow-replacing lesions.",
author = "Kim, {Yong Pyo} and Stephan Kannengiesser and Paek, {Mun Young} and Sungjun Kim and Chung, {Tae Sub} and Yoo, {Yeon Hwa} and Yoon, {Choon Sik} and Song, {Ho Taek} and Lee, {Young Han} and Jinsuck Suh",
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Differentiation between focal malignant marrow-replacing lesions and benign red marrow deposition of the spine with t2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence. / Kim, Yong Pyo; Kannengiesser, Stephan; Paek, Mun Young; Kim, Sungjun; Chung, Tae Sub; Yoo, Yeon Hwa; Yoon, Choon Sik; Song, Ho Taek; Lee, Young Han; Suh, Jinsuck.

In: Korean Journal of Radiology, Vol. 15, No. 6, 01.01.2014, p. 781-791.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differentiation between focal malignant marrow-replacing lesions and benign red marrow deposition of the spine with t2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence

AU - Kim, Yong Pyo

AU - Kannengiesser, Stephan

AU - Paek, Mun Young

AU - Kim, Sungjun

AU - Chung, Tae Sub

AU - Yoo, Yeon Hwa

AU - Yoon, Choon Sik

AU - Song, Ho Taek

AU - Lee, Young Han

AU - Suh, Jinsuck

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: To assess the feasibility of T2*-corrected fat-signal fraction (FF) map by using the three-echo volume interpolated breath-hold gradient echo (VIBE) Dixon sequence to differentiate between malignant marrow-replacing lesions and benign red marrow deposition of vertebrae.Materials and Methods: We assessed 32 lesions from 32 patients who underwent magnetic resonance imaging after being referred for assessment of a known or possible vertebral marrow abnormality. The lesions were divided into 21 malignant marrow-replacing lesions and 11 benign red marrow depositions. Three sequences for the parameter measurements were obtained by using a 1.5-T MR imaging scanner as follows: three-echo VIBE Dixon sequence for FF; conventional T1-weighted imaging for the lesion-disc ratio (LDR); pre-and post-gadolinium enhanced fat-suppressed T1-weighted images for the contrast-enhancement ratio (CER). A region of interest was drawn for each lesion for parameter measurements. The areas under the curve (AUC) of the parameters and their sensitivities and specificities at the most ideal cutoff values from receiver operating characteristic curve analysis were obtained. AUC, sensitivity, and specificity were respectively compared between FF and CER.Results: The AUCs of FF, LDR, and CER were 0.96, 0.80, and 0.72, respectively. In the comparison of diagnostic performance between the FF and CER, the FF showed a significantly larger AUC as compared to the CER (p = 0.030), although the difference of sensitivity (p = 0.157) and specificity (p = 0.157) were not significant.Conclusion: Fat-signal fraction measurement using T2*-corrected three-echo VIBE Dixon sequence is feasible and has a more accurate diagnostic performance, than the CER, in distinguishing benign red marrow deposition from malignant bone marrow-replacing lesions.

AB - Objective: To assess the feasibility of T2*-corrected fat-signal fraction (FF) map by using the three-echo volume interpolated breath-hold gradient echo (VIBE) Dixon sequence to differentiate between malignant marrow-replacing lesions and benign red marrow deposition of vertebrae.Materials and Methods: We assessed 32 lesions from 32 patients who underwent magnetic resonance imaging after being referred for assessment of a known or possible vertebral marrow abnormality. The lesions were divided into 21 malignant marrow-replacing lesions and 11 benign red marrow depositions. Three sequences for the parameter measurements were obtained by using a 1.5-T MR imaging scanner as follows: three-echo VIBE Dixon sequence for FF; conventional T1-weighted imaging for the lesion-disc ratio (LDR); pre-and post-gadolinium enhanced fat-suppressed T1-weighted images for the contrast-enhancement ratio (CER). A region of interest was drawn for each lesion for parameter measurements. The areas under the curve (AUC) of the parameters and their sensitivities and specificities at the most ideal cutoff values from receiver operating characteristic curve analysis were obtained. AUC, sensitivity, and specificity were respectively compared between FF and CER.Results: The AUCs of FF, LDR, and CER were 0.96, 0.80, and 0.72, respectively. In the comparison of diagnostic performance between the FF and CER, the FF showed a significantly larger AUC as compared to the CER (p = 0.030), although the difference of sensitivity (p = 0.157) and specificity (p = 0.157) were not significant.Conclusion: Fat-signal fraction measurement using T2*-corrected three-echo VIBE Dixon sequence is feasible and has a more accurate diagnostic performance, than the CER, in distinguishing benign red marrow deposition from malignant bone marrow-replacing lesions.

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