Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer

A case control study

Masatoshi Nakagawa, Yoon Young Choi, Ji Yeong An, Hyunsoo Chung, Sang Hyuk Seo, Hyun Beak Shin, Hui Jae Bang, Shuangxi Li, Hyung Il Kim, Jae Ho Cheong, WooJin Hyung, Sung Hoon Noh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The relationship between pathological factors and lymph node metastasis of pathological stage early gastric cancer has been extensively investigated. By contrast, the relationship between preoperative factors and lymph node metastasis of clinical stage early gastric cancer has not been investigated. The present study was to investigate discrepancies between preoperative and postoperative values. Methods: From January 2011 to December 2013, 1042 patients with clinical stage early gastric cancer who underwent gastrectomy with lymphadenectomy were enrolled. Preoperative and postoperative values were collected for subsequent analysis. Receiver operating characteristics curves were computed using independent predictive factors. Results: Several discrepancies were observed between preoperative and postoperative values, including existence of ulcer, gross type, and histology (all McNemar p-values were <0.001). Multivariate analyses identified the following independent predictive factors for lymph node metastasis: postoperative values including age (p = 0.002), tumor size (p < 0.001), and tumor depth (p < 0.001); preoperative values including age (p = 0.017), existence of ulcer (p = 0.037), tumor size (p = 0.009), and prediction of the presence of lymph node metastasis in computed tomography scans (p = 0.002). These postoperative and preoperative independent predictive factors produced areas under the receiver operating characteristics curves of 0.824 and 0.660, respectively. Conclusions: Surgeons need to be aware of limitations in preoperative predictions of the presence of lymph node metastasis for clinical stage early gastric cancer.

Original languageEnglish
Article number943
JournalBMC cancer
Volume15
Issue number1
DOIs
Publication statusPublished - 2015 Dec 1

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Stomach Neoplasms
Case-Control Studies
Lymph Nodes
Neoplasm Metastasis
ROC Curve
Ulcer
Neoplasms
Gastrectomy
Lymph Node Excision
Histology
Multivariate Analysis
Tomography

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Nakagawa, Masatoshi ; Choi, Yoon Young ; An, Ji Yeong ; Chung, Hyunsoo ; Seo, Sang Hyuk ; Shin, Hyun Beak ; Bang, Hui Jae ; Li, Shuangxi ; Kim, Hyung Il ; Cheong, Jae Ho ; Hyung, WooJin ; Noh, Sung Hoon. / Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer : A case control study. In: BMC cancer. 2015 ; Vol. 15, No. 1.
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abstract = "Background: The relationship between pathological factors and lymph node metastasis of pathological stage early gastric cancer has been extensively investigated. By contrast, the relationship between preoperative factors and lymph node metastasis of clinical stage early gastric cancer has not been investigated. The present study was to investigate discrepancies between preoperative and postoperative values. Methods: From January 2011 to December 2013, 1042 patients with clinical stage early gastric cancer who underwent gastrectomy with lymphadenectomy were enrolled. Preoperative and postoperative values were collected for subsequent analysis. Receiver operating characteristics curves were computed using independent predictive factors. Results: Several discrepancies were observed between preoperative and postoperative values, including existence of ulcer, gross type, and histology (all McNemar p-values were <0.001). Multivariate analyses identified the following independent predictive factors for lymph node metastasis: postoperative values including age (p = 0.002), tumor size (p < 0.001), and tumor depth (p < 0.001); preoperative values including age (p = 0.017), existence of ulcer (p = 0.037), tumor size (p = 0.009), and prediction of the presence of lymph node metastasis in computed tomography scans (p = 0.002). These postoperative and preoperative independent predictive factors produced areas under the receiver operating characteristics curves of 0.824 and 0.660, respectively. Conclusions: Surgeons need to be aware of limitations in preoperative predictions of the presence of lymph node metastasis for clinical stage early gastric cancer.",
author = "Masatoshi Nakagawa and Choi, {Yoon Young} and An, {Ji Yeong} and Hyunsoo Chung and Seo, {Sang Hyuk} and Shin, {Hyun Beak} and Bang, {Hui Jae} and Shuangxi Li and Kim, {Hyung Il} and Cheong, {Jae Ho} and WooJin Hyung and Noh, {Sung Hoon}",
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Nakagawa, M, Choi, YY, An, JY, Chung, H, Seo, SH, Shin, HB, Bang, HJ, Li, S, Kim, HI, Cheong, JH, Hyung, W & Noh, SH 2015, 'Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: A case control study', BMC cancer, vol. 15, no. 1, 943. https://doi.org/10.1186/s12885-015-1940-3

Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer : A case control study. / Nakagawa, Masatoshi; Choi, Yoon Young; An, Ji Yeong; Chung, Hyunsoo; Seo, Sang Hyuk; Shin, Hyun Beak; Bang, Hui Jae; Li, Shuangxi; Kim, Hyung Il; Cheong, Jae Ho; Hyung, WooJin; Noh, Sung Hoon.

In: BMC cancer, Vol. 15, No. 1, 943, 01.12.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer

T2 - A case control study

AU - Nakagawa, Masatoshi

AU - Choi, Yoon Young

AU - An, Ji Yeong

AU - Chung, Hyunsoo

AU - Seo, Sang Hyuk

AU - Shin, Hyun Beak

AU - Bang, Hui Jae

AU - Li, Shuangxi

AU - Kim, Hyung Il

AU - Cheong, Jae Ho

AU - Hyung, WooJin

AU - Noh, Sung Hoon

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background: The relationship between pathological factors and lymph node metastasis of pathological stage early gastric cancer has been extensively investigated. By contrast, the relationship between preoperative factors and lymph node metastasis of clinical stage early gastric cancer has not been investigated. The present study was to investigate discrepancies between preoperative and postoperative values. Methods: From January 2011 to December 2013, 1042 patients with clinical stage early gastric cancer who underwent gastrectomy with lymphadenectomy were enrolled. Preoperative and postoperative values were collected for subsequent analysis. Receiver operating characteristics curves were computed using independent predictive factors. Results: Several discrepancies were observed between preoperative and postoperative values, including existence of ulcer, gross type, and histology (all McNemar p-values were <0.001). Multivariate analyses identified the following independent predictive factors for lymph node metastasis: postoperative values including age (p = 0.002), tumor size (p < 0.001), and tumor depth (p < 0.001); preoperative values including age (p = 0.017), existence of ulcer (p = 0.037), tumor size (p = 0.009), and prediction of the presence of lymph node metastasis in computed tomography scans (p = 0.002). These postoperative and preoperative independent predictive factors produced areas under the receiver operating characteristics curves of 0.824 and 0.660, respectively. Conclusions: Surgeons need to be aware of limitations in preoperative predictions of the presence of lymph node metastasis for clinical stage early gastric cancer.

AB - Background: The relationship between pathological factors and lymph node metastasis of pathological stage early gastric cancer has been extensively investigated. By contrast, the relationship between preoperative factors and lymph node metastasis of clinical stage early gastric cancer has not been investigated. The present study was to investigate discrepancies between preoperative and postoperative values. Methods: From January 2011 to December 2013, 1042 patients with clinical stage early gastric cancer who underwent gastrectomy with lymphadenectomy were enrolled. Preoperative and postoperative values were collected for subsequent analysis. Receiver operating characteristics curves were computed using independent predictive factors. Results: Several discrepancies were observed between preoperative and postoperative values, including existence of ulcer, gross type, and histology (all McNemar p-values were <0.001). Multivariate analyses identified the following independent predictive factors for lymph node metastasis: postoperative values including age (p = 0.002), tumor size (p < 0.001), and tumor depth (p < 0.001); preoperative values including age (p = 0.017), existence of ulcer (p = 0.037), tumor size (p = 0.009), and prediction of the presence of lymph node metastasis in computed tomography scans (p = 0.002). These postoperative and preoperative independent predictive factors produced areas under the receiver operating characteristics curves of 0.824 and 0.660, respectively. Conclusions: Surgeons need to be aware of limitations in preoperative predictions of the presence of lymph node metastasis for clinical stage early gastric cancer.

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