Diffuse large B cell lymphoma shows distinct methylation profiles of the tumor suppressor genes among the non-Hodgkin's lymphomas

Sun Och Yoon, Young A. Kim, Yoon Kyung Jeon, Ji Eun Kim, Gyeong Hoon Kang, Chul Woo Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Aberrant methylation of CpG islands in promoter regions is one of the major mechanisms for silencing of tumor suppressor genes in various types of human cancers including non-Hodgkin's lymphomas (NHL). In this study, we investigated the aberrant promoter methylation status of known or suspected tumor suppressor genes in NHLs and compared the methylation profiles between B-cell and T/NK-cell NHLs. Methods: 54 cases of B-cell NHLs and 16 cases of T/NK-cell NHLs were examined for the methylation status of eight genes using methylation specific PCR. Results: CpG islands methylation was variously found in eight genes as follows; DAPK (71%), MT1G (70%), p16 (53%), CDH1 (53%), THBS1 (56%), MGMT (27.1%), COX2 (13%), and RUNX3 (11.4%). In six cases (8 %), methylation was not observed in any of these genes. Overall methylation index of B-cell NHLs (0.48) was significantly higher than that of T/ NK-cell NHLs (0.32). Of eight genes tested, THBS1 and CDH1 methylations were much more prominent in diffuse large B-cell lymphomas than in T/ NK-cell NHLs or other B-cell NHLs. Conclusion: This study suggests that aberrant CpG island methylation is a frequent event in NHLs, and diffuse large B-cell lymphomas show overlapping but distinct methylation profiles.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalKorean Journal of Pathology
Volume42
Issue number1
Publication statusPublished - 2008 Dec 1

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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