Diffuse reticular interstitial infiltrations in the patient with worsening exertional dyspnea after clomifen hormonal therapy

H. C. Park, Y. S. Kim, S. K. Kim, K. Y. Chung, D. H. Shin, H. L. Lee, J. Chang, S. K. Kim, W. Y. Lee

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Lymphangioleiomyomatosis is a rare disease which afflicts young women of childbearing age. We experienced a 32-year-old female who was admitted because of worsening exertional dyspnea after hormonal therapy with Clomifen for five months and intermittent hemoptysis. Chest PA showed diffuse ground glass appearance with some reticular infiltrations. High resolution CT scan showed multiple small tinn walled cysts distributed homogeneously throughout the entire lung. Pulmonary function test showed characteristic obstructive pattern despite the restrictive interstitial pattern of chest radiography. Thoracoscopic lung biopsy specimen showed abnormal proliferation of smooth muscle cells in the walls of lymphatic vessels, bronchioles, and pulmonary vessels typical of pulmonary lymphangioleiomyomatosis. Hormonal therapy with medroxyprogesterone was initiated.

Original languageEnglish
Pages (from-to)624-628
Number of pages5
JournalTuberculosis and Respiratory Diseases
Issue number4
Publication statusPublished - 1995 Jan 1


All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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