Diffusion-tensor MR imaging and fiber tractography: A new method of describing aberrant fiber connections in developmental CNS anomalies

Seung Koo Lee, Ik Kim Dong, Jinna Kim, Joon Kim Dong, HeungDong Kim, Seok Kim Dong, Susumu Mori

Research output: Contribution to journalReview article

239 Citations (Scopus)

Abstract

Congenital anomalies of the central nervous system (CNS) often demonstrate aberrant white matter connections, which may be better characterized with diffusion-tensor imaging (DTI) and fiber tractography (FT) than with conventional magnetic resonance (MR) imaging. DTI-FT demonstrates abnormal hemispheric fiber connections in callosal agenesis or acquired disease of the corpus callosum. Decreased anisotropy of white matter adjacent to the malformed cortex and an aberrant course of major fiber pathways due to dysplastic white matter are common findings in cortical dysplasia. Increased anisotropy of dysplastic gray matter in heterotopia supports the hypothesis that developing neurons migrate from the ependyma to the cortex with a radial growth pattern. In periventricular leukomalacia, DTI-FT demonstrates an intact corticospinal tract and decreased thalamocortical sensory connections, which are responsible for the spasticity of cerebral palsy owing to impairment of inhibitory function. Joubert syndrome comprises malformation of the cerebellar vermis and an aberrant connection between the cerebellum and the cerebral cortex via an elongated and abnormally shaped superior cerebellar peduncle, which are well visualized with DTI-FT. In developmental CNS disease, DTI-FT demonstrates additional findings beyond those seen with conventional MR imaging. Future studies will focus on determining the significance of the aberrant fiber connections and their relationships to the clinical manifestations of CNS anomalies.

Original languageEnglish
Pages (from-to)53-65
Number of pages13
JournalRadiographics
Volume25
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1

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Nervous System Malformations
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Central Nervous System
Anisotropy
Magnetic Resonance Imaging
Ependyma
Periventricular Leukomalacia
Agenesis of Corpus Callosum
Malformations of Cortical Development
Pyramidal Tracts
Corpus Callosum
Central Nervous System Diseases
Cerebral Palsy
Cerebral Cortex
Cerebellum
Neurons
Growth
White Matter

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lee, Seung Koo ; Dong, Ik Kim ; Kim, Jinna ; Dong, Joon Kim ; Kim, HeungDong ; Dong, Seok Kim ; Mori, Susumu. / Diffusion-tensor MR imaging and fiber tractography : A new method of describing aberrant fiber connections in developmental CNS anomalies. In: Radiographics. 2005 ; Vol. 25, No. 1. pp. 53-65.
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Diffusion-tensor MR imaging and fiber tractography : A new method of describing aberrant fiber connections in developmental CNS anomalies. / Lee, Seung Koo; Dong, Ik Kim; Kim, Jinna; Dong, Joon Kim; Kim, HeungDong; Dong, Seok Kim; Mori, Susumu.

In: Radiographics, Vol. 25, No. 1, 01.01.2005, p. 53-65.

Research output: Contribution to journalReview article

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