Diffusion tensor imaging (DTI) was applied to 12 patients with focal cortical dysplasia (FCD) in frontal or occipital cortex. Fiber tractography was obtained from seeding points in superior longitudinal fasciculus or posterior corona radiata. Mean fractional anisotropy of fiber bundles around the affected cortex was decreased in comparison to the contralateral hemisphere with statistical significance (paired t test, P = 0.0274). On visual analysis, tractography depicted decreased volume of fiber bundles connected to the dysplastic cortex invariably even in those with a normal T2 signal intensity of underlying white matter adjacent to FCD. DTI has high potential to be applied to localize the FCD and to provide a better understanding of the pathological changes in the white matter.
Bibliographical noteFunding Information:
The authors thank Drs. Frank Hoogenraad and Marc Van Cauteren for their research support on clinical DTI studies, and Dr. Hae-Jeong Park for critical review of the manuscript. This study was supported by a faculty research grant of Yonsei University College of Medicine for 2003 (No. 2003-08).
All Science Journal Classification (ASJC) codes
- Cognitive Neuroscience