Dihydrostilbene glycosides from Camellia sinensis var. assamica and their cytotoxic activity

Nguyen Thi Cuc, Duong Thi Hai Yen, Pham Hai Yen, Dan Thi Thuy Hang, Bui Huu Tai, Yohan Seo, Wan Namkung, Seung Hyun Kim, Pham Van Cuong, Phan Van Kiem, Nguyen Xuan Nhiem, Tran Minh Ngoc

Research output: Contribution to journalArticlepeer-review

Abstract

Three undescribed dihydrostilbene glycosides, 3,5-dihydroxyldihydrostilbene 4′-O-[6′′-O-(4′′′-hydroxylbenzoyl)]-β-D-glucopyranoside (1), 3,5-dihydroxyldihydrostilbene 4′-O-(6′′-O-galloyl)-β-D-glucopyranoside (2), and 3,5-dihydroxyldihydrostilbene 4′-O-[6′′-O-(3′′′,4′′′-dimethoxyl)galloyl]-β-D-glucopyranoside (3), and seven known compounds, kaempferol 3-O-β-D-glucopyranoside (4), isoquercitrin (5), kaempferol 3-O-α-L-rhamnoside (6), quercitrin (7), (6S,9R)-roseoside (8), (-)-epicatechin 3-O-gallate (9), and (-)-epigallocatechin 3-O-gallate (10) have been isolated from the methanol extract of the leaves of Camellia sinensis var. assamica (J.W.Mast.) Kitam. (synnonym of Camellia assamica (Mast.) H.T.Chang) (Theaceae). Their structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. All compounds were evaluated for cytotoxic activity against human oral cancer (CAL27) and human breast cancer (MDAMB231) cell lines. Compound 10 showed significant cytotoxic activity against CAL27 and MDAMB231 cell lines with IC50 values of 9.78 ± 0.25 and 3.27 ± 0.18 μM, respectively, compared to those of positive control, capecitabine (IC50 values of 8.20 ± 0.75 and 5.20 ± 0.89 μM).

Original languageEnglish
Pages (from-to)3931-3937
Number of pages7
JournalNatural Product Research
Volume36
Issue number15
DOIs
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2018.09.

Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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