Neuroimaging features derived from the cortical surface provide important information in detecting changes related to the progression of Alzheimer's disease (AD). Recent widespread adoption of neuroimaging has allowed researchers to study longitudinal data in AD. We adopted cortical thickness and sulcal depth, parameterized by three-dimensional meshes, from magnetic resonance imaging as the surface features. The cortical feature is high-dimensional, and it is difficult to use directly with a classifier because of the "small sample size" problem. We applied manifold learning to reduce the dimensionality of the feature and then tested the usage of the dimensionality reduced feature with a support vector machine classifier. Principal component analysis (PCA) was chosen as the method of manifold learning. PCA was applied to a region of interest within the cortical surface. We used 30 normal, 30 mild cognitive impairment (MCI) and 12 conversion cases taken from the ADNI database. The classifier was trained using the cortical features extracted from normal and MCI patients. The classifier was tested for the 12 conversion patients only using the imaging data before the actual conversion. The conversion was predicted early with an accuracy of 83%.
Bibliographical noteFunding Information:
This study was supported by KOSEF NLRL Program grant 2011-0028333 , Basic Science Research Program through NRF Korea grants 2012R1A2A2A01005939 , 20100023233 , and Global Frontier RD Program on through NRF Korea grant NRF-2011-0032035 . Image data collection was supported by NIH grants U01AG024904 , P30AG010129 , K01AG030514 and the Dana Foundation .
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