Dimethylthiourea prevents MPTP-induced decrease in [3H]dopamine uptake in rat striatal slices

Jihoe Heo, Goo Kim Dong Goo Kim, Ryun Bahng Hye Ryun Bahng, Kim Jin-Soo Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To determine whethr oxygen free radicals are involved in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, the effect of dimethylthiourea (DMTU), an effective hydroxyl radical scavenger, on MPTP-induced changes of [3H]dopamine uptake was investigated in rat striatal slices. The uptake of [3H]dopamine was decreased by MPTP treatment, and DMTU prevented the MPTP-induced decreases of [3H]dopamine uptake in a dose-dependent manner. The highest dose of DMTU used in this study completely prevented the MPTP-induced decrease of [3H]dopamine uptake. These results indicate that free radicals play a major role in the pathogenetic mechanism of MPTP-induced neurotoxicity.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalBrain Research
Volume671
Issue number2
DOIs
Publication statusPublished - 1995 Feb 13

Fingerprint

Corpus Striatum
Dopamine
Free Radicals
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Hydroxyl Radical
Reactive Oxygen Species
4-phenyl-1,2,3,6-tetrahydropyridine
1,3-dimethylthiourea

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Heo, Jihoe ; Dong Goo Kim, Goo Kim ; Hye Ryun Bahng, Ryun Bahng ; Jin-Soo Kim, Kim. / Dimethylthiourea prevents MPTP-induced decrease in [3H]dopamine uptake in rat striatal slices. In: Brain Research. 1995 ; Vol. 671, No. 2. pp. 321-324.
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Dimethylthiourea prevents MPTP-induced decrease in [3H]dopamine uptake in rat striatal slices. / Heo, Jihoe; Dong Goo Kim, Goo Kim; Hye Ryun Bahng, Ryun Bahng; Jin-Soo Kim, Kim.

In: Brain Research, Vol. 671, No. 2, 13.02.1995, p. 321-324.

Research output: Contribution to journalArticle

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T1 - Dimethylthiourea prevents MPTP-induced decrease in [3H]dopamine uptake in rat striatal slices

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AB - To determine whethr oxygen free radicals are involved in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, the effect of dimethylthiourea (DMTU), an effective hydroxyl radical scavenger, on MPTP-induced changes of [3H]dopamine uptake was investigated in rat striatal slices. The uptake of [3H]dopamine was decreased by MPTP treatment, and DMTU prevented the MPTP-induced decreases of [3H]dopamine uptake in a dose-dependent manner. The highest dose of DMTU used in this study completely prevented the MPTP-induced decrease of [3H]dopamine uptake. These results indicate that free radicals play a major role in the pathogenetic mechanism of MPTP-induced neurotoxicity.

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