Dimethylthiourea prevents MPTP-induced decrease in [3H]dopamine uptake in rat striatal slices

Hoe Heo Ji Hoe Heo, Goo Kim Dong Goo Kim, Ryun Bahng Hye Ryun Bahng, Kim Jin-Soo Kim

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Abstract

To determine whethr oxygen free radicals are involved in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, the effect of dimethylthiourea (DMTU), an effective hydroxyl radical scavenger, on MPTP-induced changes of [3H]dopamine uptake was investigated in rat striatal slices. The uptake of [3H]dopamine was decreased by MPTP treatment, and DMTU prevented the MPTP-induced decreases of [3H]dopamine uptake in a dose-dependent manner. The highest dose of DMTU used in this study completely prevented the MPTP-induced decrease of [3H]dopamine uptake. These results indicate that free radicals play a major role in the pathogenetic mechanism of MPTP-induced neurotoxicity.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalBrain Research
Volume671
Issue number2
DOIs
Publication statusPublished - 1995 Feb 13

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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