The direct, catalytic arylation of simple arenes in small excess with aryl bromides is disclosed. The developed method does not require the assistance of directing groups and relies on a synergistic catalytic cycle in which phosphine-ligated silver complexes cleave the aryl C-H bond, while palladium catalysts enable the formation of the biaryl products. Mechanistic experiments, including kinetic isotope effects, competition experiments, and hydrogen-deuterium exchange, support a catalytic cycle in which cleavage of the C-H bond by silver is the rate-determining step.
|Number of pages||5|
|Publication status||Published - 2021 Feb 5|
Bibliographical noteFunding Information:
We gratefully acknowledge financial support from the NIH (R35 GM130387 to J.F.H. and F32-GM113404 to S.Y.L.). We thank the College of Chemistry’s NMR facility for resources provided and the staff for their assistance. Instruments in CoC-NMR are supported in part by the NIH (S10OD024998). A.T.A Thanks UC MEXUS-CONACYT for a Postdoctoral Research Fellowship.
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