Abstract
Stem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior for better clinical performance. Since native microenvironment factors including stem cell niche, genetic factors, and growth factors direct stem cell fate cooperatively, user-specified in vitro settings are required to understand the regulatory roles and effects of each factor, thereby applying the factors for improved cell therapy. Among others, various types of biomaterials and transfection method have been employed as key tools for development of the in vitro settings. This review focuses on the current strategies to improve stemness maintenance, direct differentiation, and reprogramming using biomaterials and genetic factors without any aids from additional biochemicals and growth factors.
| Original language | English |
|---|---|
| Article number | 8642989 |
| Journal | Stem Cells International |
| Volume | 2018 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology
Cite this
}
Direct control of stem cell behavior using biomaterials and genetic factors. / Yoon, Jeong Kee; Kang, Mi Lan; Park, Joo Hyun; Lee, Kyoung Mi; Shin, Young Min; Lee, Jin Woo; Kim, Hyun Ok; Sung, Hak Joon.
In: Stem Cells International, Vol. 2018, 8642989, 01.01.2018.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Direct control of stem cell behavior using biomaterials and genetic factors
AU - Yoon, Jeong Kee
AU - Kang, Mi Lan
AU - Park, Joo Hyun
AU - Lee, Kyoung Mi
AU - Shin, Young Min
AU - Lee, Jin Woo
AU - Kim, Hyun Ok
AU - Sung, Hak Joon
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Stem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior for better clinical performance. Since native microenvironment factors including stem cell niche, genetic factors, and growth factors direct stem cell fate cooperatively, user-specified in vitro settings are required to understand the regulatory roles and effects of each factor, thereby applying the factors for improved cell therapy. Among others, various types of biomaterials and transfection method have been employed as key tools for development of the in vitro settings. This review focuses on the current strategies to improve stemness maintenance, direct differentiation, and reprogramming using biomaterials and genetic factors without any aids from additional biochemicals and growth factors.
AB - Stem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior for better clinical performance. Since native microenvironment factors including stem cell niche, genetic factors, and growth factors direct stem cell fate cooperatively, user-specified in vitro settings are required to understand the regulatory roles and effects of each factor, thereby applying the factors for improved cell therapy. Among others, various types of biomaterials and transfection method have been employed as key tools for development of the in vitro settings. This review focuses on the current strategies to improve stemness maintenance, direct differentiation, and reprogramming using biomaterials and genetic factors without any aids from additional biochemicals and growth factors.
UR - http://www.scopus.com/inward/record.url?scp=85058977592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058977592&partnerID=8YFLogxK
U2 - 10.1155/2018/8642989
DO - 10.1155/2018/8642989
M3 - Review article
AN - SCOPUS:85058977592
VL - 2018
JO - Stem Cells International
JF - Stem Cells International
SN - 1687-9678
M1 - 8642989
ER -