Direct-current treatment as a safe sterilization method for electrospun biodegradable polymer

Hye Lee Kim, Jeong Hyun Lee, Mi Hee Lee, Hak Hee Kim, Jungsung Kim, Inho Han, Bong Joo Park, Jeong Koo Kim, Dong Wook Han, Soo Hyun Kim, Seung Jin Lee, Jongchul Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sterilization is an essential process for biodegradable polymers to be used as biomaterials or tissue engineered- scaffolds. The characteristics of biodegradable scaffolds can change due to decomposition of constituent polymers due to high temperature, pressure, or moisture during sterilization. This study investigated direct-current (DC) treatment as a safe method that can prevent structural change and deformation. Treatment of electrospun poly (lactic-co-glycolic acid) (PLGA) with DC showed a bactericidal effect within 40 sec at 4 V. When DC was applied at 6 V to the electrospun PLGA, the bactericidal effect emerged within 30 sec. The morphology of fibers and molecular weight of PLGA polymer was maintained after DC treatment. In contrast, electrospun PLGA exposed to ethylene oxide showed fiber degradation, and gamma or e-beam irradiation resulted in decreased molecular weight. The demonstrated improvement in chemical and physical stability of biodegradable polymers after DC sterilization may help extend their application.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalTissue Engineering and Regenerative Medicine
Volume8
Issue number3
Publication statusPublished - 2011 May 1

Fingerprint

Biodegradable polymers
Polymers
Acids
Molecular Weight
Molecular weight
Tissue Scaffolds
Ethylene Oxide
Fibers
Biocompatible Materials
Biomaterials
Scaffolds
Ethylene
Moisture
Irradiation
Decomposition
Pressure
Degradation
Temperature
Oxides
Milk

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Kim, Hye Lee ; Lee, Jeong Hyun ; Lee, Mi Hee ; Kim, Hak Hee ; Kim, Jungsung ; Han, Inho ; Park, Bong Joo ; Kim, Jeong Koo ; Han, Dong Wook ; Kim, Soo Hyun ; Lee, Seung Jin ; Park, Jongchul. / Direct-current treatment as a safe sterilization method for electrospun biodegradable polymer. In: Tissue Engineering and Regenerative Medicine. 2011 ; Vol. 8, No. 3. pp. 320-325.
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Kim, HL, Lee, JH, Lee, MH, Kim, HH, Kim, J, Han, I, Park, BJ, Kim, JK, Han, DW, Kim, SH, Lee, SJ & Park, J 2011, 'Direct-current treatment as a safe sterilization method for electrospun biodegradable polymer', Tissue Engineering and Regenerative Medicine, vol. 8, no. 3, pp. 320-325.

Direct-current treatment as a safe sterilization method for electrospun biodegradable polymer. / Kim, Hye Lee; Lee, Jeong Hyun; Lee, Mi Hee; Kim, Hak Hee; Kim, Jungsung; Han, Inho; Park, Bong Joo; Kim, Jeong Koo; Han, Dong Wook; Kim, Soo Hyun; Lee, Seung Jin; Park, Jongchul.

In: Tissue Engineering and Regenerative Medicine, Vol. 8, No. 3, 01.05.2011, p. 320-325.

Research output: Contribution to journalArticle

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AU - Lee, Mi Hee

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AU - Kim, Jungsung

AU - Han, Inho

AU - Park, Bong Joo

AU - Kim, Jeong Koo

AU - Han, Dong Wook

AU - Kim, Soo Hyun

AU - Lee, Seung Jin

AU - Park, Jongchul

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