Direct diversification of unmasked quinazolin-4(3: H)-ones through orthogonal reactivity modulation

Jae Bin Lee, Mi Eun Kang, Joohee Kim, Chang Young Lee, Jung Min Kee, Kyungjae Myung, Jang-Ung Park, Sung You Hong

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting groups or exogenous coordinating moieties. Divergent pathways were modulated with transition-metal catalysts by suppressing competitive reactivities, leading to N-arylation, annulative π-extension, or C-H fluorination.

Original languageEnglish
Pages (from-to)10394-10397
Number of pages4
JournalChemical Communications
Volume53
Issue number75
DOIs
Publication statusPublished - 2017 Jan 1

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Alkaloids
Fluorination
Transition metals
Modulation
Catalysts

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Lee, J. B., Kang, M. E., Kim, J., Lee, C. Y., Kee, J. M., Myung, K., ... Hong, S. Y. (2017). Direct diversification of unmasked quinazolin-4(3: H)-ones through orthogonal reactivity modulation. Chemical Communications, 53(75), 10394-10397. https://doi.org/10.1039/c7cc05794f
Lee, Jae Bin ; Kang, Mi Eun ; Kim, Joohee ; Lee, Chang Young ; Kee, Jung Min ; Myung, Kyungjae ; Park, Jang-Ung ; Hong, Sung You. / Direct diversification of unmasked quinazolin-4(3 : H)-ones through orthogonal reactivity modulation. In: Chemical Communications. 2017 ; Vol. 53, No. 75. pp. 10394-10397.
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Direct diversification of unmasked quinazolin-4(3 : H)-ones through orthogonal reactivity modulation. / Lee, Jae Bin; Kang, Mi Eun; Kim, Joohee; Lee, Chang Young; Kee, Jung Min; Myung, Kyungjae; Park, Jang-Ung; Hong, Sung You.

In: Chemical Communications, Vol. 53, No. 75, 01.01.2017, p. 10394-10397.

Research output: Contribution to journalArticle

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