Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting groups or exogenous coordinating moieties. Divergent pathways were modulated with transition-metal catalysts by suppressing competitive reactivities, leading to N-arylation, annulative π-extension, or C-H fluorination.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea (NRF-2016R1A2B4015497) and the IT R&D program of MOTIE/KEIT (10046306). We are grateful to Prof. R. Tenne for his helpful comments.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry