An efficient and direct one-pot glycosylation method using anomeric hydroxy sugars as glycosyl donors, employing 3-fluorophthalic anhydride and triflic anhydride as activating agents, has been developed. The present glycosylation utilizing 3-fluorophthalic anhydride resulted in few to no undesired self-condensed esters than the glycosylation using phthalic anhydride. Intermediates in the present glycosylation were identified by an NMR study.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation (NRF) grant funded by the Korea government (MEST) through the Center for Bioactive Molecular Hybrids (No. R11-2003-019-00000-0 ).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry