Direct glycosylation with anomeric hydroxy sugars by activation with 3-fluorophthalic anhydride and trifluoromethanesulfonic anhydride

Ju Yuel Baek, Bo Young Lee, Rita Pal, Wonyong Lee, Kwan Soo Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

An efficient and direct one-pot glycosylation method using anomeric hydroxy sugars as glycosyl donors, employing 3-fluorophthalic anhydride and triflic anhydride as activating agents, has been developed. The present glycosylation utilizing 3-fluorophthalic anhydride resulted in few to no undesired self-condensed esters than the glycosylation using phthalic anhydride. Intermediates in the present glycosylation were identified by an NMR study.

Original languageEnglish
Pages (from-to)6250-6254
Number of pages5
JournalTetrahedron Letters
Volume51
Issue number48
DOIs
Publication statusPublished - 2010 Dec 1

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Glycosylation
Anhydrides
Sugars
Chemical activation
Esters
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

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abstract = "An efficient and direct one-pot glycosylation method using anomeric hydroxy sugars as glycosyl donors, employing 3-fluorophthalic anhydride and triflic anhydride as activating agents, has been developed. The present glycosylation utilizing 3-fluorophthalic anhydride resulted in few to no undesired self-condensed esters than the glycosylation using phthalic anhydride. Intermediates in the present glycosylation were identified by an NMR study.",
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Direct glycosylation with anomeric hydroxy sugars by activation with 3-fluorophthalic anhydride and trifluoromethanesulfonic anhydride. / Baek, Ju Yuel; Lee, Bo Young; Pal, Rita; Lee, Wonyong; Kim, Kwan Soo.

In: Tetrahedron Letters, Vol. 51, No. 48, 01.12.2010, p. 6250-6254.

Research output: Contribution to journalArticle

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AU - Kim, Kwan Soo

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