Direct N-alkylation of aromatic amines using a microflow reactor: Enhancement of selectivity and reactivity

Yong Sung Choi, Yoon Jung Kim, Liu Lan Shen, Yong Sup Lee, Jin Hyun Jeong

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2 Citations (Scopus)


A simple and highly atom-economical method for the direct N-alkylation of aromatic amines by using a microflow reactor was developed to overcome the problem of over-alkylation. In the developed method, high-yield conversion (up to 100%) was achieved in a relatively short reaction time. The ratio of mono- to di-benzylated products (3.57:1) was higher than that achieved with batch reactions conducted in a 1 L scale flask (0.87:1). The structural features of the microflow reactor meant that short-chain alkyl halides could be converted into products with high reactivity and selectivity under superheating conditions, although their boiling point was much lower than the reaction temperature. This method was successfully applied to the synthesis of a range of secondary amines including an intermediate of indobufen synthesis.

Original languageEnglish
Article numberst-2014-u1017-l
Pages (from-to)970-974
Number of pages5
Issue number7
Publication statusPublished - 2015 Apr 1


All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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