A peptide-αthiophenylester is a key reactant in native chemical ligation. Preformation of the peptide-αthiophenylester could be useful for enhancing the ligation reaction. We report the direct on-resin preparation of preformed peptide-αthiophenylesters using a simple and efficient method. The peptide- αthiophenylester reacted extremely rapidly with a Cys-peptide when compared to the peptide-αthioalkylester.
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry