TY - GEN
T1 - Direct photo-thermal diagnosis of anemia using platinum resistance temperature detector
AU - Kwak, Bong Seop
AU - Kim, Hyung Joon
AU - Kim, Hyun Ok
AU - Jung, Hyo Il
PY - 2010
Y1 - 2010
N2 - This article presents a thermal biosensor to diagnose anemia without chemical treatments using temperature increases of red blood cells when hemoglobin molecules absorb photons of specific wavelengths and convert them to thermal energy. For measuring the temperature changes, a micro-scaled platinum resistance temperature detector was developed. We also designed and fabricated a thermostat system to maintain a constant ambient temperature (<±0.1°C). An 8.0W/cm2 diode pumped solid state (DPSS) continuous wave (CW) laser module with a wavelength of 532 nm was used to heat the red blood cells. Using this system, we successfully measured temperature variations of whole blood samples from 10 anemic patients and subsequently determined the concentration of hemoglobin. The method proposed in this paper requires significantly smaller quantities of whole blood (6μl), as compared with conventional methods (175μl), and allows instantaneous diagnosis (6 seconds) of anemia.
AB - This article presents a thermal biosensor to diagnose anemia without chemical treatments using temperature increases of red blood cells when hemoglobin molecules absorb photons of specific wavelengths and convert them to thermal energy. For measuring the temperature changes, a micro-scaled platinum resistance temperature detector was developed. We also designed and fabricated a thermostat system to maintain a constant ambient temperature (<±0.1°C). An 8.0W/cm2 diode pumped solid state (DPSS) continuous wave (CW) laser module with a wavelength of 532 nm was used to heat the red blood cells. Using this system, we successfully measured temperature variations of whole blood samples from 10 anemic patients and subsequently determined the concentration of hemoglobin. The method proposed in this paper requires significantly smaller quantities of whole blood (6μl), as compared with conventional methods (175μl), and allows instantaneous diagnosis (6 seconds) of anemia.
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U2 - 10.1109/ICSENS.2010.5690620
DO - 10.1109/ICSENS.2010.5690620
M3 - Conference contribution
AN - SCOPUS:79951862301
SN - 9781424481682
T3 - Proceedings of IEEE Sensors
SP - 1230
EP - 1233
BT - IEEE Sensors 2010 Conference, SENSORS 2010
T2 - 9th IEEE Sensors Conference 2010, SENSORS 2010
Y2 - 1 November 2010 through 4 November 2010
ER -