Discovery and synthesis of novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors

Hwan Song Jong, Gi Kim Sun, Sung No Zae, Young Lan Hyun, Ju Jeon Dong, Ikyon Kim

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4 Citations (Scopus)

Abstract

The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.

Original languageEnglish
Pages (from-to)1467-1471
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume29
Issue number8
DOIs
Publication statusPublished - 2008 Aug 20

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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