Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Jérémy Ricci; Minkyu Kim; Won Yoon Chung; Kwang Kyun Park; Mankil Jung

doi:10.1248/cpb.59.1471

Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Jérémy Ricci, Minkyu Kim, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20μM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.

Original language	English
Pages (from-to)	1471-1475
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	12
DOIs	https://doi.org/10.1248/cpb.59.1471
Publication status	Published - 2011

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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