Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Jérémy Ricci, Minkyu Kim, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20μM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.

Original languageEnglish
Pages (from-to)1471-1475
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume59
Issue number12
DOIs
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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