Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Jérémy Ricci, Minkyu Kim, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20μM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.

Original languageEnglish
Pages (from-to)1471-1475
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume59
Issue number12
DOIs
Publication statusPublished - 2011 Dec 12

Fingerprint

Mouth Neoplasms
Glycolipids
Paclitaxel
Cisplatin
Cells
Carcinoma
Cell Line
artemisinine

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Ricci, Jérémy ; Kim, Minkyu ; Chung, Won Yoon ; Park, Kwang Kyun ; Jung, Mankil. / Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents. In: Chemical and Pharmaceutical Bulletin. 2011 ; Vol. 59, No. 12. pp. 1471-1475.
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Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents. / Ricci, Jérémy; Kim, Minkyu; Chung, Won Yoon; Park, Kwang Kyun; Jung, Mankil.

In: Chemical and Pharmaceutical Bulletin, Vol. 59, No. 12, 12.12.2011, p. 1471-1475.

Research output: Contribution to journalArticle

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