Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Jérémy Ricci; Minkyu Kim; Won Yoon Chung; Kwang Kyun Park; Mankil Jung

doi:10.1248/cpb.59.1471

Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Jérémy Ricci, Minkyu Kim, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20μM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.

Original language	English
Pages (from-to)	1471-1475
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	12
DOIs	https://doi.org/10.1248/cpb.59.1471
Publication status	Published - 2011

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1248/cpb.59.1471

Cite this

@article{e898cf1f095749feae84b6e7ada0a513,

title = "Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents",

abstract = "Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20μM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.",

author = "J{\'e}r{\'e}my Ricci and Minkyu Kim and Chung, {Won Yoon} and Park, {Kwang Kyun} and Mankil Jung",

year = "2011",

doi = "10.1248/cpb.59.1471",

language = "English",

volume = "59",

pages = "1471--1475",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "12",

}

TY - JOUR

T1 - Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

AU - Ricci, Jérémy

AU - Kim, Minkyu

AU - Chung, Won Yoon

AU - Park, Kwang Kyun

AU - Jung, Mankil

PY - 2011

Y1 - 2011

N2 - Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20μM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.

AB - Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20μM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.

UR - http://www.scopus.com/inward/record.url?scp=82955249853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82955249853&partnerID=8YFLogxK

U2 - 10.1248/cpb.59.1471

DO - 10.1248/cpb.59.1471

M3 - Article

C2 - 22130368

AN - SCOPUS:82955249853

VL - 59

SP - 1471

EP - 1475

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 12

ER -

Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this