Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Vu Kim Thu, Nguyen Xuan Bach, Luu The Anh, Do Thi Trang, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim

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Abstract

Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalPhytochemistry Letters
Volume33
DOIs
Publication statusPublished - 2019 Oct

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

Cite this

Thu, V. K., Bach, N. X., Anh, L. T., Trang, D. T., Nhiem, N. X., Tai, B. H., Van Kiem, P., Van Minh, C., Park, S. J., Seo, Y., Namkung, W., & Kim, S. H. (2019). Discovery of cycloartane-type triterpene saponins from Mussaenda glabra. Phytochemistry Letters, 33, 39-45. https://doi.org/10.1016/j.phytol.2019.07.006