Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Vu Kim Thu, Nguyen Xuan Bach, Luu The Anh, Do Thi Trang, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim

Research output: Contribution to journalArticle

Abstract

Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalPhytochemistry Letters
Volume33
DOIs
Publication statusPublished - 2019 Oct

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Mussaenda
chloride channels
Triterpenes
Chloride Channels
triterpenoid saponins
Saponins
saponins
HT29 Cells
Cytotoxicity
Inhibitory Concentration 50
inhibitory concentration 50
cytotoxicity
Nuclear magnetic resonance
calcium
leaves
cells
cycloartane
methodology

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

Cite this

Thu, Vu Kim ; Bach, Nguyen Xuan ; Anh, Luu The ; Trang, Do Thi ; Nhiem, Nguyen Xuan ; Tai, Bui Huu ; Van Kiem, Phan ; Van Minh, Chau ; Park, Seon Ju ; Seo, Yohan ; Namkung, Wan ; Kim, Seung Hyun. / Discovery of cycloartane-type triterpene saponins from Mussaenda glabra. In: Phytochemistry Letters. 2019 ; Vol. 33. pp. 39-45.
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abstract = "Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.",
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Thu, VK, Bach, NX, Anh, LT, Trang, DT, Nhiem, NX, Tai, BH, Van Kiem, P, Van Minh, C, Park, SJ, Seo, Y, Namkung, W & Kim, SH 2019, 'Discovery of cycloartane-type triterpene saponins from Mussaenda glabra', Phytochemistry Letters, vol. 33, pp. 39-45. https://doi.org/10.1016/j.phytol.2019.07.006

Discovery of cycloartane-type triterpene saponins from Mussaenda glabra. / Thu, Vu Kim; Bach, Nguyen Xuan; Anh, Luu The; Trang, Do Thi; Nhiem, Nguyen Xuan; Tai, Bui Huu; Van Kiem, Phan; Van Minh, Chau; Park, Seon Ju; Seo, Yohan; Namkung, Wan; Kim, Seung Hyun.

In: Phytochemistry Letters, Vol. 33, 10.2019, p. 39-45.

Research output: Contribution to journalArticle

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AU - Thu, Vu Kim

AU - Bach, Nguyen Xuan

AU - Anh, Luu The

AU - Trang, Do Thi

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Van Kiem, Phan

AU - Van Minh, Chau

AU - Park, Seon Ju

AU - Seo, Yohan

AU - Namkung, Wan

AU - Kim, Seung Hyun

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