Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.
Bibliographical noteFunding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2016.27 , Vietnam and by the National Research Foundation of Korea (NRF) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea .
© 2019 Phytochemical Society of Europe
All Science Journal Classification (ASJC) codes
- Agronomy and Crop Science
- Plant Science