Discovery of novel indazole-linked triazoles as antifungal agents

Joon Seok Park, Kyung A. Yu, Tae Hee Kang, Sunghoon Kim, Young Ger Suh

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The in vitro and in vivo activities of a series of (2R, 3R)-2-(2,4-difluorophenyl)-3-(substituted indazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol as potential antifungal agents are described. In particular, the analog 12j having 5-bromo substitution on the indazole ring exhibited significant antifungal activity against a variety of fungal cultures (Candida spp. and Aspergillus spp.). In addition, oral administration of 12j showed its excellent efficacy against Candida albicans in a murine infection model and the significantly improved survival rates of the infected mice.

Original languageEnglish
Pages (from-to)3486-3490
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number12
DOIs
Publication statusPublished - 2007 Jun 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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