Disease phenotype, activity and clinical course prediction based on c-reactive protein levels at diagnosis in patients with Crohn's disease: Results from the connect study

Jee Hye Kwon, Jong Pil Im, Byong Duk Ye, Jae Hee Cheon, Hyun Joo Jang, Kang Moon Lee, You Sun Kim, Sang Wook Kim, Young Ho Kim, Geun Am Song, Dong Soo Han, Won Ho Kim, Joo Sung Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: C-reactive protein (CRP) is an easily measured index of disease activity, but its ability to predict clinical course is controversial. We therefore designed a study to determine whether the CRP level at Crohn's disease (CD) diagnosis is a valuable indicator of the disease phenotype, activity, and clinical course. Methods: We retrospectively analyzed 705 CD patients from 32 institutions. The patients were classified into two groups according to CRP level. The patients' demographic and clinical characteristics and their use of immunosuppressive or biological agents were recorded. Disease location and behavior, hospitalization, and surgery were analyzed. Results: A high CRP was associated with younger age, steroid use, colonic or ileocolonic location, high CD activity index, and active inflammation at colonoscopy (p<0.001). As the disease progressed, patients with high CRP were more likely to exhibit strictures (p=0.027). There were significant differences in the use of 5-aminosalicylic acid, antibiotics, corticosteroids, azathioprine, and infliximab (p<0.001, p<0.001, p<0.001, p<0.001, and p=0.023, respectively). Hospitalization was also more frequent in patients with high CRP. Conclusions: The CRP level at diagnosis is useful for evaluating the phenotype, activity, and clinical course of CD. Closer follow-up strategies, with early aggressive treatment, could be considered for patients with high CRP. (.

Original languageEnglish
Pages (from-to)595-603
Number of pages9
JournalGut and liver
Volume10
Issue number4
DOIs
Publication statusPublished - 2016 Jul

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Crohn Disease
C-Reactive Protein
Phenotype
Proteins
Hospitalization
Mesalamine
Azathioprine
Biological Factors
Colonoscopy
Immunosuppressive Agents
Adrenal Cortex Hormones
Pathologic Constriction
Steroids
Demography
Anti-Bacterial Agents
Inflammation

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kwon, Jee Hye ; Im, Jong Pil ; Ye, Byong Duk ; Cheon, Jae Hee ; Jang, Hyun Joo ; Lee, Kang Moon ; Kim, You Sun ; Kim, Sang Wook ; Kim, Young Ho ; Song, Geun Am ; Han, Dong Soo ; Kim, Won Ho ; Kim, Joo Sung. / Disease phenotype, activity and clinical course prediction based on c-reactive protein levels at diagnosis in patients with Crohn's disease : Results from the connect study. In: Gut and liver. 2016 ; Vol. 10, No. 4. pp. 595-603.
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title = "Disease phenotype, activity and clinical course prediction based on c-reactive protein levels at diagnosis in patients with Crohn's disease: Results from the connect study",
abstract = "Background/Aims: C-reactive protein (CRP) is an easily measured index of disease activity, but its ability to predict clinical course is controversial. We therefore designed a study to determine whether the CRP level at Crohn's disease (CD) diagnosis is a valuable indicator of the disease phenotype, activity, and clinical course. Methods: We retrospectively analyzed 705 CD patients from 32 institutions. The patients were classified into two groups according to CRP level. The patients' demographic and clinical characteristics and their use of immunosuppressive or biological agents were recorded. Disease location and behavior, hospitalization, and surgery were analyzed. Results: A high CRP was associated with younger age, steroid use, colonic or ileocolonic location, high CD activity index, and active inflammation at colonoscopy (p<0.001). As the disease progressed, patients with high CRP were more likely to exhibit strictures (p=0.027). There were significant differences in the use of 5-aminosalicylic acid, antibiotics, corticosteroids, azathioprine, and infliximab (p<0.001, p<0.001, p<0.001, p<0.001, and p=0.023, respectively). Hospitalization was also more frequent in patients with high CRP. Conclusions: The CRP level at diagnosis is useful for evaluating the phenotype, activity, and clinical course of CD. Closer follow-up strategies, with early aggressive treatment, could be considered for patients with high CRP. (.",
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Disease phenotype, activity and clinical course prediction based on c-reactive protein levels at diagnosis in patients with Crohn's disease : Results from the connect study. / Kwon, Jee Hye; Im, Jong Pil; Ye, Byong Duk; Cheon, Jae Hee; Jang, Hyun Joo; Lee, Kang Moon; Kim, You Sun; Kim, Sang Wook; Kim, Young Ho; Song, Geun Am; Han, Dong Soo; Kim, Won Ho; Kim, Joo Sung.

In: Gut and liver, Vol. 10, No. 4, 07.2016, p. 595-603.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Disease phenotype, activity and clinical course prediction based on c-reactive protein levels at diagnosis in patients with Crohn's disease

T2 - Results from the connect study

AU - Kwon, Jee Hye

AU - Im, Jong Pil

AU - Ye, Byong Duk

AU - Cheon, Jae Hee

AU - Jang, Hyun Joo

AU - Lee, Kang Moon

AU - Kim, You Sun

AU - Kim, Sang Wook

AU - Kim, Young Ho

AU - Song, Geun Am

AU - Han, Dong Soo

AU - Kim, Won Ho

AU - Kim, Joo Sung

PY - 2016/7

Y1 - 2016/7

N2 - Background/Aims: C-reactive protein (CRP) is an easily measured index of disease activity, but its ability to predict clinical course is controversial. We therefore designed a study to determine whether the CRP level at Crohn's disease (CD) diagnosis is a valuable indicator of the disease phenotype, activity, and clinical course. Methods: We retrospectively analyzed 705 CD patients from 32 institutions. The patients were classified into two groups according to CRP level. The patients' demographic and clinical characteristics and their use of immunosuppressive or biological agents were recorded. Disease location and behavior, hospitalization, and surgery were analyzed. Results: A high CRP was associated with younger age, steroid use, colonic or ileocolonic location, high CD activity index, and active inflammation at colonoscopy (p<0.001). As the disease progressed, patients with high CRP were more likely to exhibit strictures (p=0.027). There were significant differences in the use of 5-aminosalicylic acid, antibiotics, corticosteroids, azathioprine, and infliximab (p<0.001, p<0.001, p<0.001, p<0.001, and p=0.023, respectively). Hospitalization was also more frequent in patients with high CRP. Conclusions: The CRP level at diagnosis is useful for evaluating the phenotype, activity, and clinical course of CD. Closer follow-up strategies, with early aggressive treatment, could be considered for patients with high CRP. (.

AB - Background/Aims: C-reactive protein (CRP) is an easily measured index of disease activity, but its ability to predict clinical course is controversial. We therefore designed a study to determine whether the CRP level at Crohn's disease (CD) diagnosis is a valuable indicator of the disease phenotype, activity, and clinical course. Methods: We retrospectively analyzed 705 CD patients from 32 institutions. The patients were classified into two groups according to CRP level. The patients' demographic and clinical characteristics and their use of immunosuppressive or biological agents were recorded. Disease location and behavior, hospitalization, and surgery were analyzed. Results: A high CRP was associated with younger age, steroid use, colonic or ileocolonic location, high CD activity index, and active inflammation at colonoscopy (p<0.001). As the disease progressed, patients with high CRP were more likely to exhibit strictures (p=0.027). There were significant differences in the use of 5-aminosalicylic acid, antibiotics, corticosteroids, azathioprine, and infliximab (p<0.001, p<0.001, p<0.001, p<0.001, and p=0.023, respectively). Hospitalization was also more frequent in patients with high CRP. Conclusions: The CRP level at diagnosis is useful for evaluating the phenotype, activity, and clinical course of CD. Closer follow-up strategies, with early aggressive treatment, could be considered for patients with high CRP. (.

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DO - 10.5009/gnl15411

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VL - 10

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