Disordered Nanocomposite Islands for Nanospeckle Illumination Microscopy in Wide-Field Super-Resolution Imaging

Hajun Yoo, Hongki Lee, Woo Joong Rhee, Gwiyeong Moon, Changhun Lee, Seung Ah Lee, Jeon Soo Shin, Donghyun Kim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Nanospeckle illumination microscopy (NanoSIM) based on disordered metallic nanocomposite island substrates is described. The nanoisland substrates can be fabricated without lithographic techniques. Azimuthal scanning illumination of nanoislands creates near-field distribution that excites an arbitrary number of basis images to produce super-resolution. Experimental studies of point-spread images using NanoSIM with 360 basis images obtained by azimuthal scanning find spatial resolution improved by more than three times with an achievable full-width-at-half-maximum at 81.1 nm on average. The approach is confirmed by imaging aggregated nanobeads and nanoscale distribution of gangliosides on the HeLa cell membrane.

Original languageEnglish
Article number2100211
JournalAdvanced Optical Materials
Issue number15
Publication statusPublished - 2021 Aug 4

Bibliographical note

Funding Information:
The authors are grateful for the support by the National Research Foundation (NRF) grants funded by the Korean Government (2019R1A4A1025958) and the Korea Medical Device Development Fund (Project Number: 202011D25). W.J.R. and J.‐S.S. acknowledge the support by the NRF (2019R1A6A1A03032869). The funding agencies had no role in the design or conduct of this study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or in the decision to submit the manuscript for publication.

Publisher Copyright:
© 2021 Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics


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