Disseminated Mycobacterium kansasii infection associated with skin lesions: A case report and comprehensive review of the literature

Sang Hoon Han, Kyoung Min Kim, Bum Sik Chin, Suk Hoon Choi, Han Sung Lee, Myung Soo Kim, Su Jin Jeong, Hee Kyoung Choi, Chang Oh Kim, Jun Yong Choi, Young Goo Song, June Myung Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Mycobacteruim kansasii occasionally causes disseminated infection with poor outcome in immunocompromised patients. We report the first case of disseminated M. kansasii infection associated with multiple skin lesions in a 48-yr-old male with myelodysplastic syndrome. The patient continuously had taken glucocorticoid during 21 months and had multiple skin lesions developed before 9 months without complete resolution until admission. Skin and mediastinoscopic paratracheal lymph node (LN) biopsies showed necrotizing granuloma with many acid-fast bacilli. M. kansasii was cultured from skin, sputum, and paratracheal LNs. The patient had been treated successfully with isoniazid, rifampin, ethmabutol, and clarithromycin, but died due to small bowel obstruction. Our case emphasizes that chronic skin lesions can lead to severe, disseminated M. kansasii infection in an immunocompromised patient. All available cases of disseminated M. kansasii infection in non HIV-infected patients reported since 1953 are comprehensively reviewed.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalJournal of Korean medical science
Volume25
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

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Mycobacterium kansasii
Mycobacterium Infections
Skin
Immunocompromised Host
Clarithromycin
Myelodysplastic Syndromes
Isoniazid
Rifampin
Granuloma
Sputum
Bacillus
Glucocorticoids
Lymph Nodes
HIV
Biopsy
Acids
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Han, Sang Hoon ; Kim, Kyoung Min ; Chin, Bum Sik ; Choi, Suk Hoon ; Lee, Han Sung ; Kim, Myung Soo ; Jeong, Su Jin ; Choi, Hee Kyoung ; Kim, Chang Oh ; Choi, Jun Yong ; Song, Young Goo ; Kim, June Myung. / Disseminated Mycobacterium kansasii infection associated with skin lesions : A case report and comprehensive review of the literature. In: Journal of Korean medical science. 2010 ; Vol. 25, No. 2. pp. 304-308.
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Han, SH, Kim, KM, Chin, BS, Choi, SH, Lee, HS, Kim, MS, Jeong, SJ, Choi, HK, Kim, CO, Choi, JY, Song, YG & Kim, JM 2010, 'Disseminated Mycobacterium kansasii infection associated with skin lesions: A case report and comprehensive review of the literature', Journal of Korean medical science, vol. 25, no. 2, pp. 304-308. https://doi.org/10.3346/jkms.2010.25.2.304

Disseminated Mycobacterium kansasii infection associated with skin lesions : A case report and comprehensive review of the literature. / Han, Sang Hoon; Kim, Kyoung Min; Chin, Bum Sik; Choi, Suk Hoon; Lee, Han Sung; Kim, Myung Soo; Jeong, Su Jin; Choi, Hee Kyoung; Kim, Chang Oh; Choi, Jun Yong; Song, Young Goo; Kim, June Myung.

In: Journal of Korean medical science, Vol. 25, No. 2, 01.02.2010, p. 304-308.

Research output: Contribution to journalArticle

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