Dissemination of Escherichia coli producing AmpC-type β-lactamase (CMY-11) in Korea

Jae Young Kim, Jae Seok Song, Song Hee Bak, Young Eun Cho, Dae Wi Kim, Seok Hoon Jeong, Yeong Min Park, Kye Joon Lee, Sang Hee Lee

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8 Citations (Scopus)

Abstract

Among the 51 clinical isolates collected from a university hospital in Korea, nine isolates were resistant to cephamycins. Nine isolates were shown to produce CMY-11 and these also included three isolates producing TEM-1. The results from ERIC-PCR revealed that dissemination of CMY-11 was due to outbreaks of resistant species and to the intra-species spread of resistance to cephamycins in Korea. CMY-11 β-lactamase genes from nine clinical isolates that were responsible for resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin and amoxicillin-clavulanic acid, were cloned and characterised. A sequence identical to the common regions in In6, In7 and a novel integron from pSAL-1 was found upstream from bla CMY-11 gene at nucleotide 1-71. Eighteen nucleotides between position 71 and 72 were inserted into the bla CMY-11 gene.

Original languageEnglish
Pages (from-to)320-326
Number of pages7
JournalInternational Journal of Antimicrobial Agents
Volume24
Issue number4
DOIs
Publication statusPublished - 2004 Oct 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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