Dissemination of Escherichia coli producing AmpC-type β-lactamase (CMY-11) in Korea

Jae Young Kim, Jae Seok Song, Song Hee Bak, Young Eun Cho, Dae Wi Kim, Seokhoon Jeong, Yeong Min Park, Kye Joon Lee, Sang Hee Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Among the 51 clinical isolates collected from a university hospital in Korea, nine isolates were resistant to cephamycins. Nine isolates were shown to produce CMY-11 and these also included three isolates producing TEM-1. The results from ERIC-PCR revealed that dissemination of CMY-11 was due to outbreaks of resistant species and to the intra-species spread of resistance to cephamycins in Korea. CMY-11 β-lactamase genes from nine clinical isolates that were responsible for resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin and amoxicillin-clavulanic acid, were cloned and characterised. A sequence identical to the common regions in In6, In7 and a novel integron from pSAL-1 was found upstream from bla CMY-11 gene at nucleotide 1-71. Eighteen nucleotides between position 71 and 72 were inserted into the bla CMY-11 gene.

Original languageEnglish
Pages (from-to)320-326
Number of pages7
JournalInternational Journal of Antimicrobial Agents
Volume24
Issue number4
DOIs
Publication statusPublished - 2004 Oct 1

Fingerprint

Cephamycins
Korea
Escherichia coli
Nucleotides
Cefotetan
Integrons
Genes
Cephalothin
Amoxicillin-Potassium Clavulanate Combination
Cefoxitin
Amoxicillin
Disease Outbreaks
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Kim, Jae Young ; Song, Jae Seok ; Bak, Song Hee ; Cho, Young Eun ; Kim, Dae Wi ; Jeong, Seokhoon ; Park, Yeong Min ; Lee, Kye Joon ; Lee, Sang Hee. / Dissemination of Escherichia coli producing AmpC-type β-lactamase (CMY-11) in Korea. In: International Journal of Antimicrobial Agents. 2004 ; Vol. 24, No. 4. pp. 320-326.
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Dissemination of Escherichia coli producing AmpC-type β-lactamase (CMY-11) in Korea. / Kim, Jae Young; Song, Jae Seok; Bak, Song Hee; Cho, Young Eun; Kim, Dae Wi; Jeong, Seokhoon; Park, Yeong Min; Lee, Kye Joon; Lee, Sang Hee.

In: International Journal of Antimicrobial Agents, Vol. 24, No. 4, 01.10.2004, p. 320-326.

Research output: Contribution to journalArticle

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