Distal protection device protects microvascular integrity during primary percutaneous intervention in acute myocardial infarction: A prospective, randomized, multicenter trial

Seung Jea Tahk, Byoung Joo Choi, So Yeon Choi, Myeong Ho Yoon, Hyeon Cheol Gwon, Geu Ru Hong, Young Jo Kim, Seung Ho Hur, Kwon Bae Kim, Bon Kwon Koo, Seung Hwan Lee, Junghan Yoon

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Distal protection during primary angioplasty in acute myocardial infarction (AMI) is the subject of recent controversy. The present study was designed to determine whether the distal embolic protection preserves myocardial microvascular integrity and improves clinical outcomes in patients with AMI. Methods: A total of 116 AMI patients presenting within 12 h of onset of symptoms were enrolled at 7 angioplasty centers. They were randomly assigned to either primary angioplasty with distal protection group (DP; n = 60) or angioplasty alone group (Controls; n = 56). Results: After primary angioplasty, achievement of final Thrombolysis In Myocardial Infarction (TIMI) grade 3 and TIMI Myocardial Perfusion (TMP) grade 3 were more frequent in the DP group than in the control group [58/60 (96%) vs. 43/56 (81%), p = 0.016; and 39/60 (65%) vs. 20/56 (38%), p = 0.001, respectively]. After primary angioplasty, the baseline and hyperemic averaged peak velocities were significantly higher (23.2 ± 11.5 vs. 18.0 ± 6.9 cm/s, p = 0.029; and 39.2 ± 16.7 vs. 30.6 ± 10.8 cm/s, p = 0.014, respectively) and the baseline and hyperemic microvascular resistance indices were significantly lower (4.18 ± 2.22 vs. 5.34 ± 2.25 mm Hg cm- 1 s, p = 0.036; and 2.38 ±1.39 vs. 3.11 ± 1.32 mm Hg cm- 1 s, p = 0.030, respectively) in the DP group. Patients in the DP group showed more favorable phasic coronary flow pattern in diastolic deceleration time (679 ± 262 vs. 519 ± 289 ms, p = 0.035; and 751 ± 246 vs. 616 ± 269 ms, p = 0.035, respectively). Major adverse cardiac events at 6 months occurred with similar frequency in both groups (8.7% vs. 11.1%, p = 0.400). Conclusions: Distal protection device effectively preserves microvascular integrity during primary angioplasty in AMI. Distal protection, however, did not improve clinical outcomes.

Original languageEnglish
Pages (from-to)162-168
Number of pages7
JournalInternational Journal of Cardiology
Volume123
Issue number2
DOIs
Publication statusPublished - 2008 Jan 11

Fingerprint

Angioplasty
Multicenter Studies
Myocardial Infarction
Equipment and Supplies
Control Groups
Deceleration
Perfusion

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Tahk, Seung Jea ; Choi, Byoung Joo ; Choi, So Yeon ; Yoon, Myeong Ho ; Gwon, Hyeon Cheol ; Hong, Geu Ru ; Kim, Young Jo ; Hur, Seung Ho ; Kim, Kwon Bae ; Koo, Bon Kwon ; Lee, Seung Hwan ; Yoon, Junghan. / Distal protection device protects microvascular integrity during primary percutaneous intervention in acute myocardial infarction : A prospective, randomized, multicenter trial. In: International Journal of Cardiology. 2008 ; Vol. 123, No. 2. pp. 162-168.
@article{2ee0358010034dcaa10759ec9e99e9fe,
title = "Distal protection device protects microvascular integrity during primary percutaneous intervention in acute myocardial infarction: A prospective, randomized, multicenter trial",
abstract = "Background: Distal protection during primary angioplasty in acute myocardial infarction (AMI) is the subject of recent controversy. The present study was designed to determine whether the distal embolic protection preserves myocardial microvascular integrity and improves clinical outcomes in patients with AMI. Methods: A total of 116 AMI patients presenting within 12 h of onset of symptoms were enrolled at 7 angioplasty centers. They were randomly assigned to either primary angioplasty with distal protection group (DP; n = 60) or angioplasty alone group (Controls; n = 56). Results: After primary angioplasty, achievement of final Thrombolysis In Myocardial Infarction (TIMI) grade 3 and TIMI Myocardial Perfusion (TMP) grade 3 were more frequent in the DP group than in the control group [58/60 (96{\%}) vs. 43/56 (81{\%}), p = 0.016; and 39/60 (65{\%}) vs. 20/56 (38{\%}), p = 0.001, respectively]. After primary angioplasty, the baseline and hyperemic averaged peak velocities were significantly higher (23.2 ± 11.5 vs. 18.0 ± 6.9 cm/s, p = 0.029; and 39.2 ± 16.7 vs. 30.6 ± 10.8 cm/s, p = 0.014, respectively) and the baseline and hyperemic microvascular resistance indices were significantly lower (4.18 ± 2.22 vs. 5.34 ± 2.25 mm Hg cm- 1 s, p = 0.036; and 2.38 ±1.39 vs. 3.11 ± 1.32 mm Hg cm- 1 s, p = 0.030, respectively) in the DP group. Patients in the DP group showed more favorable phasic coronary flow pattern in diastolic deceleration time (679 ± 262 vs. 519 ± 289 ms, p = 0.035; and 751 ± 246 vs. 616 ± 269 ms, p = 0.035, respectively). Major adverse cardiac events at 6 months occurred with similar frequency in both groups (8.7{\%} vs. 11.1{\%}, p = 0.400). Conclusions: Distal protection device effectively preserves microvascular integrity during primary angioplasty in AMI. Distal protection, however, did not improve clinical outcomes.",
author = "Tahk, {Seung Jea} and Choi, {Byoung Joo} and Choi, {So Yeon} and Yoon, {Myeong Ho} and Gwon, {Hyeon Cheol} and Hong, {Geu Ru} and Kim, {Young Jo} and Hur, {Seung Ho} and Kim, {Kwon Bae} and Koo, {Bon Kwon} and Lee, {Seung Hwan} and Junghan Yoon",
year = "2008",
month = "1",
day = "11",
doi = "10.1016/j.ijcard.2007.03.124",
language = "English",
volume = "123",
pages = "162--168",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Distal protection device protects microvascular integrity during primary percutaneous intervention in acute myocardial infarction : A prospective, randomized, multicenter trial. / Tahk, Seung Jea; Choi, Byoung Joo; Choi, So Yeon; Yoon, Myeong Ho; Gwon, Hyeon Cheol; Hong, Geu Ru; Kim, Young Jo; Hur, Seung Ho; Kim, Kwon Bae; Koo, Bon Kwon; Lee, Seung Hwan; Yoon, Junghan.

In: International Journal of Cardiology, Vol. 123, No. 2, 11.01.2008, p. 162-168.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Distal protection device protects microvascular integrity during primary percutaneous intervention in acute myocardial infarction

T2 - A prospective, randomized, multicenter trial

AU - Tahk, Seung Jea

AU - Choi, Byoung Joo

AU - Choi, So Yeon

AU - Yoon, Myeong Ho

AU - Gwon, Hyeon Cheol

AU - Hong, Geu Ru

AU - Kim, Young Jo

AU - Hur, Seung Ho

AU - Kim, Kwon Bae

AU - Koo, Bon Kwon

AU - Lee, Seung Hwan

AU - Yoon, Junghan

PY - 2008/1/11

Y1 - 2008/1/11

N2 - Background: Distal protection during primary angioplasty in acute myocardial infarction (AMI) is the subject of recent controversy. The present study was designed to determine whether the distal embolic protection preserves myocardial microvascular integrity and improves clinical outcomes in patients with AMI. Methods: A total of 116 AMI patients presenting within 12 h of onset of symptoms were enrolled at 7 angioplasty centers. They were randomly assigned to either primary angioplasty with distal protection group (DP; n = 60) or angioplasty alone group (Controls; n = 56). Results: After primary angioplasty, achievement of final Thrombolysis In Myocardial Infarction (TIMI) grade 3 and TIMI Myocardial Perfusion (TMP) grade 3 were more frequent in the DP group than in the control group [58/60 (96%) vs. 43/56 (81%), p = 0.016; and 39/60 (65%) vs. 20/56 (38%), p = 0.001, respectively]. After primary angioplasty, the baseline and hyperemic averaged peak velocities were significantly higher (23.2 ± 11.5 vs. 18.0 ± 6.9 cm/s, p = 0.029; and 39.2 ± 16.7 vs. 30.6 ± 10.8 cm/s, p = 0.014, respectively) and the baseline and hyperemic microvascular resistance indices were significantly lower (4.18 ± 2.22 vs. 5.34 ± 2.25 mm Hg cm- 1 s, p = 0.036; and 2.38 ±1.39 vs. 3.11 ± 1.32 mm Hg cm- 1 s, p = 0.030, respectively) in the DP group. Patients in the DP group showed more favorable phasic coronary flow pattern in diastolic deceleration time (679 ± 262 vs. 519 ± 289 ms, p = 0.035; and 751 ± 246 vs. 616 ± 269 ms, p = 0.035, respectively). Major adverse cardiac events at 6 months occurred with similar frequency in both groups (8.7% vs. 11.1%, p = 0.400). Conclusions: Distal protection device effectively preserves microvascular integrity during primary angioplasty in AMI. Distal protection, however, did not improve clinical outcomes.

AB - Background: Distal protection during primary angioplasty in acute myocardial infarction (AMI) is the subject of recent controversy. The present study was designed to determine whether the distal embolic protection preserves myocardial microvascular integrity and improves clinical outcomes in patients with AMI. Methods: A total of 116 AMI patients presenting within 12 h of onset of symptoms were enrolled at 7 angioplasty centers. They were randomly assigned to either primary angioplasty with distal protection group (DP; n = 60) or angioplasty alone group (Controls; n = 56). Results: After primary angioplasty, achievement of final Thrombolysis In Myocardial Infarction (TIMI) grade 3 and TIMI Myocardial Perfusion (TMP) grade 3 were more frequent in the DP group than in the control group [58/60 (96%) vs. 43/56 (81%), p = 0.016; and 39/60 (65%) vs. 20/56 (38%), p = 0.001, respectively]. After primary angioplasty, the baseline and hyperemic averaged peak velocities were significantly higher (23.2 ± 11.5 vs. 18.0 ± 6.9 cm/s, p = 0.029; and 39.2 ± 16.7 vs. 30.6 ± 10.8 cm/s, p = 0.014, respectively) and the baseline and hyperemic microvascular resistance indices were significantly lower (4.18 ± 2.22 vs. 5.34 ± 2.25 mm Hg cm- 1 s, p = 0.036; and 2.38 ±1.39 vs. 3.11 ± 1.32 mm Hg cm- 1 s, p = 0.030, respectively) in the DP group. Patients in the DP group showed more favorable phasic coronary flow pattern in diastolic deceleration time (679 ± 262 vs. 519 ± 289 ms, p = 0.035; and 751 ± 246 vs. 616 ± 269 ms, p = 0.035, respectively). Major adverse cardiac events at 6 months occurred with similar frequency in both groups (8.7% vs. 11.1%, p = 0.400). Conclusions: Distal protection device effectively preserves microvascular integrity during primary angioplasty in AMI. Distal protection, however, did not improve clinical outcomes.

UR - http://www.scopus.com/inward/record.url?scp=37049015572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37049015572&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2007.03.124

DO - 10.1016/j.ijcard.2007.03.124

M3 - Article

C2 - 17490759

AN - SCOPUS:37049015572

VL - 123

SP - 162

EP - 168

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 2

ER -