Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets

Jin Sil Choi, Soojin Kim, Dongwon Yoo, Tae Hyun Shin, Hoyoung Kim, Muller D. Gomes, Sun Hee Kim, Alexander Pines, Jinwoo Cheon

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Nanoscale distance-dependent phenomena, such as Förster resonance energy transfer, are important interactions for use in sensing and imaging, but their versatility for bioimaging can be limited by undesirable photon interactions with the surrounding biological matrix, especially in in vivo systems. Here, we report a new type of magnetism-based nanoscale distance-dependent phenomenon that can quantitatively and reversibly sense and image intra-/intermolecular interactions of biologically important targets. We introduce distance-dependent magnetic resonance tuning (MRET), which occurs between a paramagnetic 'enhancer' and a superparamagnetic 'quencher', where the T1 magnetic resonance imaging (MRI) signal is tuned ON or OFF depending on the separation distance between the quencher and the enhancer. With MRET, we demonstrate the principle of an MRI-based ruler for nanometre-scale distance measurement and the successful detection of both molecular interactions (for example, cleavage, binding, folding and unfolding) and biological targets in in vitro and in vivo systems. MRET can serve as a novel sensing principle to augment the exploration of a wide range of biological systems.

Original languageEnglish
Pages (from-to)537-542
Number of pages6
JournalNature materials
Volume16
Issue number5
DOIs
Publication statusPublished - 2017 May 1

Fingerprint

Magnetic resonance
magnetic resonance
platforms
Tuning
tuning
Imaging techniques
Distance measurement
Molecular interactions
Magnetism
interactions
molecular interactions
Biological systems
versatility
Energy transfer
folding
cleavage
Photons
energy transfer
photons
matrices

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Choi, Jin Sil ; Kim, Soojin ; Yoo, Dongwon ; Shin, Tae Hyun ; Kim, Hoyoung ; Gomes, Muller D. ; Kim, Sun Hee ; Pines, Alexander ; Cheon, Jinwoo. / Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets. In: Nature materials. 2017 ; Vol. 16, No. 5. pp. 537-542.
@article{2ac1599a34ee4110b0da9a01f7790dc2,
title = "Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets",
abstract = "Nanoscale distance-dependent phenomena, such as F{\"o}rster resonance energy transfer, are important interactions for use in sensing and imaging, but their versatility for bioimaging can be limited by undesirable photon interactions with the surrounding biological matrix, especially in in vivo systems. Here, we report a new type of magnetism-based nanoscale distance-dependent phenomenon that can quantitatively and reversibly sense and image intra-/intermolecular interactions of biologically important targets. We introduce distance-dependent magnetic resonance tuning (MRET), which occurs between a paramagnetic 'enhancer' and a superparamagnetic 'quencher', where the T1 magnetic resonance imaging (MRI) signal is tuned ON or OFF depending on the separation distance between the quencher and the enhancer. With MRET, we demonstrate the principle of an MRI-based ruler for nanometre-scale distance measurement and the successful detection of both molecular interactions (for example, cleavage, binding, folding and unfolding) and biological targets in in vitro and in vivo systems. MRET can serve as a novel sensing principle to augment the exploration of a wide range of biological systems.",
author = "Choi, {Jin Sil} and Soojin Kim and Dongwon Yoo and Shin, {Tae Hyun} and Hoyoung Kim and Gomes, {Muller D.} and Kim, {Sun Hee} and Alexander Pines and Jinwoo Cheon",
year = "2017",
month = "5",
day = "1",
doi = "10.1038/nmat4846",
language = "English",
volume = "16",
pages = "537--542",
journal = "Nature Materials",
issn = "1476-1122",
publisher = "Nature Publishing Group",
number = "5",

}

Choi, JS, Kim, S, Yoo, D, Shin, TH, Kim, H, Gomes, MD, Kim, SH, Pines, A & Cheon, J 2017, 'Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets', Nature materials, vol. 16, no. 5, pp. 537-542. https://doi.org/10.1038/nmat4846

Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets. / Choi, Jin Sil; Kim, Soojin; Yoo, Dongwon; Shin, Tae Hyun; Kim, Hoyoung; Gomes, Muller D.; Kim, Sun Hee; Pines, Alexander; Cheon, Jinwoo.

In: Nature materials, Vol. 16, No. 5, 01.05.2017, p. 537-542.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets

AU - Choi, Jin Sil

AU - Kim, Soojin

AU - Yoo, Dongwon

AU - Shin, Tae Hyun

AU - Kim, Hoyoung

AU - Gomes, Muller D.

AU - Kim, Sun Hee

AU - Pines, Alexander

AU - Cheon, Jinwoo

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Nanoscale distance-dependent phenomena, such as Förster resonance energy transfer, are important interactions for use in sensing and imaging, but their versatility for bioimaging can be limited by undesirable photon interactions with the surrounding biological matrix, especially in in vivo systems. Here, we report a new type of magnetism-based nanoscale distance-dependent phenomenon that can quantitatively and reversibly sense and image intra-/intermolecular interactions of biologically important targets. We introduce distance-dependent magnetic resonance tuning (MRET), which occurs between a paramagnetic 'enhancer' and a superparamagnetic 'quencher', where the T1 magnetic resonance imaging (MRI) signal is tuned ON or OFF depending on the separation distance between the quencher and the enhancer. With MRET, we demonstrate the principle of an MRI-based ruler for nanometre-scale distance measurement and the successful detection of both molecular interactions (for example, cleavage, binding, folding and unfolding) and biological targets in in vitro and in vivo systems. MRET can serve as a novel sensing principle to augment the exploration of a wide range of biological systems.

AB - Nanoscale distance-dependent phenomena, such as Förster resonance energy transfer, are important interactions for use in sensing and imaging, but their versatility for bioimaging can be limited by undesirable photon interactions with the surrounding biological matrix, especially in in vivo systems. Here, we report a new type of magnetism-based nanoscale distance-dependent phenomenon that can quantitatively and reversibly sense and image intra-/intermolecular interactions of biologically important targets. We introduce distance-dependent magnetic resonance tuning (MRET), which occurs between a paramagnetic 'enhancer' and a superparamagnetic 'quencher', where the T1 magnetic resonance imaging (MRI) signal is tuned ON or OFF depending on the separation distance between the quencher and the enhancer. With MRET, we demonstrate the principle of an MRI-based ruler for nanometre-scale distance measurement and the successful detection of both molecular interactions (for example, cleavage, binding, folding and unfolding) and biological targets in in vitro and in vivo systems. MRET can serve as a novel sensing principle to augment the exploration of a wide range of biological systems.

UR - http://www.scopus.com/inward/record.url?scp=85011684846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011684846&partnerID=8YFLogxK

U2 - 10.1038/nmat4846

DO - 10.1038/nmat4846

M3 - Article

VL - 16

SP - 537

EP - 542

JO - Nature Materials

JF - Nature Materials

SN - 1476-1122

IS - 5

ER -