Distinct clinical courses of epithelial ovarian cancer with mutations in BRCA1 5’ and 3’ exons

Kyung Jin Eoh, Hyung Seok Park, Ji Soo Park, Seung Tae Lee, Jung Woo Han, Jung Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Eun Ji Nam

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background/Aim: This study aimed to determine the effect of different BRCA1 exonal mutations on the clinical course of epithelial ovarian cancer (EOC). Patients and Methods: Clinicopathological variables and survival outcomes were compared among 53 primary EOC patients with pathogenic BRCA1 mutations in exons 1-11 (5’ mutations) and in exons 12-24 (3’ mutations). Results: BRCA1 5’ exonal mutations were found in 35 (66.0%) patients. The median follow-up period was 40 months. Clinicopathological variables remained unchanged between the two groups. Patients with 5’mutations had a significantly longer progression-free survival than those with C-terminal mutations (p=0.034), better predicting progression-free survival [2.923 (1.402-6.093), p=0.004], but not overall survival in cases of multiple relapses (p=0.497). Conclusion: N-terminal BRCA1 mutations in EOC patients are associated with favourable primary progression-free survival, a trend observed only in primary progression-free survival, not in overall survival.

Original languageEnglish
Pages (from-to)6947-6953
Number of pages7
JournalAnticancer research
Volume38
Issue number12
DOIs
Publication statusPublished - 2018 Dec

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (2014R1A1A1 A05002926 2017R1A2B4005503) and Faculty Research Grant of Yousei University College of Medicine (6-2018-0053). The funding body did not influence the study design, collection, analysis, or interpretation of data.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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