Distinct immunological properties of the two histological subtypes of adenocarcinoma of the ampulla of Vater

Min Hwan Kim, Mi Jang, Hoguen Kim, Woo Jung Lee, Chang Moo Kang, Hye Jin Choi

Research output: Contribution to journalArticle

Abstract

Adenocarcinoma of the ampulla of Vater (AOV) is classified into intestinal type (IT) and pancreatobiliary type (PB); however, the immunological properties of these subtypes remain to be characterized. Here, we evaluated the clinical implications of PD-L1 expression and CD8 + T lymphocyte density in adenocarcinomas of the AOV and their potential association with Yes-associated protein (YAP). We analyzed 123 adenocarcinoma-of-the-AOV patients who underwent surgical resection, and tumors were classified into IT or PB type. Tumor or inflammatory cell PD-L1 expression, CD8 + T lymphocyte density in the cancer cell nest (intratumoral) or in the adjacent stroma, and YAP localization and intensity were analyzed using immunohistochemical staining. PB-type tumors showed higher tumoral PD-L1 expression than IT-type tumors, and tumoral PD-L1 expression was associated with a shorter disease-free survival (DFS) [hazard ratio (HR), 1.77; p = 0.045] and overall survival (OS) (HR 1.99; p = 0.030). Intratumoral CD8 + T lymphocyte density was higher in IT type than in PB type and was associated with a favorable DFS (HR 0.47; p = 0.022). The nuclear staining pattern of YAP in tumor cells, compared to non-nuclear staining patterns, was more frequently associated with PB type and increased tumoral PD-L1 expression. Nuclear YAP staining was a significant prognostic factor for OS (HR 2.21; p = 0.022). These results show that the two subtypes of adenocarcinoma of the AOV exhibit significant differences in tumoral PD-L1 expression and intratumoral CD8 + T lymphocyte density, which might contribute to their distinct clinical features.

Original languageEnglish
Pages (from-to)443-454
Number of pages12
JournalCancer Immunology, Immunotherapy
Volume68
Issue number3
DOIs
Publication statusPublished - 2019 Mar 13

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Ampulla of Vater
Adenocarcinoma
Staining and Labeling
T-Lymphocytes
Neoplasms
Disease-Free Survival
Proteins
Survival

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

Cite this

Kim, Min Hwan ; Jang, Mi ; Kim, Hoguen ; Lee, Woo Jung ; Kang, Chang Moo ; Choi, Hye Jin. / Distinct immunological properties of the two histological subtypes of adenocarcinoma of the ampulla of Vater. In: Cancer Immunology, Immunotherapy. 2019 ; Vol. 68, No. 3. pp. 443-454.
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Distinct immunological properties of the two histological subtypes of adenocarcinoma of the ampulla of Vater. / Kim, Min Hwan; Jang, Mi; Kim, Hoguen; Lee, Woo Jung; Kang, Chang Moo; Choi, Hye Jin.

In: Cancer Immunology, Immunotherapy, Vol. 68, No. 3, 13.03.2019, p. 443-454.

Research output: Contribution to journalArticle

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